Washington University Institute of Clinical and Translational Sciences

华盛顿大学临床与转化科学研究所

• 批准号: 10556449
• 负责人: William G. Powderly
• 金额: $ 1016.11万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-19 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556449
• 关键词: Address; Adopted; Advocate; Affect; Biological Factors; Biometry; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Community Health; Complex; Data Set; Development; Disease; Dissemination and Implementation; Ecosystem; Elderly; Ensure; Environmental Risk Factor; Faculty; Foundations; Genomics; Goals; Health; Healthcare; Healthcare Systems; Home; Human; Illinois; Individual; Industry; Informatics; Infrastructure; Institutes; Institution; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Life; Logistics; Longevity; Mentors; Methodology; Methods; Missouri; Multi-Institutional Clinical Trial; Outcome; Participant; Patients; Population; Population Heterogeneity; Powder dose form; Process; Productivity; Research; Research Personnel; Resources; Rural Population; Saints; Science; Socioeconomic Factors; Special Population; Target Populations; Technology; Time; Training; Training Programs; Translating; Translational Research; Translations; Universities; Urban Population; Washington; Work; Workforce Development; archive data; archived data; base; clinical practice; community engagement; data integration; digital; dissemination science; diverse data; education research; fundamental research; genome sciences; health difference; health disparity; implementation design; implementation science; improved; informatics tool; innovation; interoperability; multidisciplinary; multiscale data; programs; rural environment; social determinants; translational impact; urban setting

Contact PD/PI: Powderly, William G. Overall Component, 7. Project Summary/Abstract: The Institute of Clinical and Translational Sciences aligns with the CTSA goals of developing innovative solutions to improve the efficiency, quality, and impact of translational science. We will pursue five aims: Aim 1: Advance interdisciplinary programs to develop, promote, mentor, and retain highly qualified and diverse faculty, trainees, and staff who translate scientific discoveries into action, thereby becoming agents for change in their institutions and communities. We will enhance our existing research education and training programs, expand and diversify our workforce, and promote team science approaches to conduct and translate high-impact research that has the potential for changing the health of our community. (Translational Workforce Development). Aim 2: Facilitate research designed for implementation by engaging diverse communities and stakeholders in multidisciplinary collaborative teams at all stages of the translational research process, thereby demonstrating the benefit and impact of translational science. We will improve community health by collaborating with patient advocates, developing new partnerships, advancing the science of collaboration, and capitalizing on strengths in implementation science (Collaboration and Engagement). Aim 3: Integrate research across individual lifespans and apply translational science in complex and diverse populations to improve individual and community health through meaningful research collaborations and sustainable partnerships. We will address health disparities across the lifespan and among special populations, identify challenges that differentially affect urban and rural populations, catalyze the formation of transdisciplinary teams, and evaluate the outcomes of our work (Integration). Aim 4: Drive innovation, quality, efficiency, and inclusion in translational research to enhance collaborations and catalyze the implementation of discovery science. We will solve key logistical roadblocks in translational science and implement innovative methods to engage stakeholders and research participants, thereby targeting different populations, life stages, and health states (Methods and Processes). Aim 5: Apply innovative informatics and biostatistics solutions to improve quality and efficiency at every stage of translational research, and create an ecosystem that integrates diverse data and facilitates the interoperability, use, and reuse of digital assets. We will ensure the interoperability of current and archived data sets, implement new informatics technologies to enhance investigator productivity, and promote the formation of interdisciplinary research teams (Informatics). Impact. Successful completion of these five aims will transform translational research, accelerate the dissemination of new innovations across our entire population, and strengthen and diversify our workforce. Project Summary/Abstract Page 235 Contact PD/PI: Powderly, William G. Overall Component 8.

联系PD/PI：Powderly，William G. 整体结构，7。项目概要/摘要： 临床和转化科学研究所与CTSA的目标一致，即开发创新的 提高转化科学的效率、质量和影响力的解决方案。我们将追求五个目标： 目标1：推进跨学科项目，以发展、促进、指导和留住高素质人才 以及将科学发现转化为行动的各种教师、学员和工作人员， 成为其机构和社区变革的推动者。我们将加强现有的研究 教育和培训计划，扩大和多样化我们的劳动力，并促进团队科学的方法 开展和翻译具有改变我们社区健康潜力的高影响力研究。 （翻译人才发展）。 目标2：通过让不同社区参与，促进为执行而设计的研究， 在翻译研究的各个阶段的多学科合作团队的利益相关者 过程，从而证明了转化科学的好处和影响。完善 通过与患者倡导者合作，发展新的伙伴关系，推进科学， 协作，并利用实施科学的优势（协作和参与）。 目标3：整合跨个人生命周期的研究，并在复杂和复杂的环境中应用转化科学。 通过有意义的研究改善个人和社区健康 合作和可持续的伙伴关系。我们将解决整个生命周期的健康差距， 在特殊人群中，确定对城市和农村人口产生不同影响的挑战， 组建跨学科团队，并评估我们的工作成果（整合）。 目标4：推动转化研究的创新、质量、效率和包容性， 合作和促进发现科学的实施。我们会解决关键的后勤问题 在转化科学的障碍，并实施创新的方法，使利益相关者和研究 参与者，从而针对不同的人群，生命阶段和健康状态（方法和过程）。 目标5：应用创新的信息学和生物统计学解决方案，提高质量和效率， 每个阶段的转化研究，并创建一个生态系统，整合不同的数据， 促进数字资产的互操作性、使用和重用。我们将确保 现有和存档的数据集，采用新的信息技术，以提高调查人员的生产力， 促进跨学科研究团队（信息学）的形成。 冲击成功完成这五个目标将改变转化研究，加速 在我们的全体人口中传播新的创新，加强我们的劳动力队伍并使之多样化。 项目摘要/摘要第235页 联系PD/PI：Powderly，William G. 总体组件 8.