Association of Perceived Stress and Cognition

感知压力与认知的关联

• 批准号: 10552041
• 负责人: Ambar Kulshreshtha
• 金额: $ 17.94万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10552041
• 关键词: Address; Affect; African American; African American population; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Amyloid beta-Protein; Area; Attention; Behavior; Behavior Therapy; Behavioral Mechanisms; Biological Markers; Blood Vessels; Board Certification; Brain; Cardiovascular Diseases; Chronic stress; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Cohort Studies; Complex; Data Analyses; Dementia; Diet; Discrimination; Disease; Disparity; Elderly; Episodic memory; Ethnic Origin; Event; Family Physicians; Family Practice; Foundations; Glucocorticoids; Goals; Health; Hormones; Impaired cognition; Incidence; Individual; Intervention; Knowledge; Life; Life Cycle Stages; Literature; Longitudinal Studies; Measurement; Measures; Mediating; Memory; Mentored Patient-Oriented Research Career Development Award; Minority Groups; Modification; Nature; Nerve Degeneration; Neuropsychology; Online Systems; Outcome; Pathway interactions; Patients; Pattern; Persons; Population; Prevalence; Prevention; Prevention strategy; Preventive Medicine; Primary Care; Program Description; Psychological Stress; Public Health; Questionnaires; Race; Reasons for Geographic And Racial Differences in Stroke; Reduce health disparities; Research; Research Personnel; Risk Factors; Role; Smoking; Socioeconomic Factors; Stress; Subgroup; Testing; Training; Training Programs; United States; United States National Institutes of Health; Universities; Work; abeta deposition; acceptability and feasibility; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular risk factor; career; clinical care; cognitive function; cognitive performance; cohort; coping; design; disease disparity; executive function; experience; health disparity; high risk; high risk population; hypothalamic-pituitary-adrenal axis; improved; interdisciplinary approach; lifestyle intervention; mild cognitive impairment; minority stress; modifiable risk; multidisciplinary; neurodevelopment; novel; patient oriented; perceived discrimination; perceived stress; physical inactivity; prevent; primary outcome; prodromal Alzheimer' s disease; programs; prospective; psychosocial stressors; racial population; specific biomarkers; stress reduction; stressor; tau Proteins; web-based intervention

Project/Summary Abstract African Americans are twice as likely to develop Alzheimer's disease (AD) as Whites, but few studies have focused on these cognitive disparities and related mechanisms. Perceived stress in minority groups such as African Americans, directly affects cognition and also plays a role in worsening of CVD risk factors and unhealthy behaviors such as smoking, improper diet, and physical inactivity. Further understanding the role of modifiable risk factors such as perceived stress in cognitive decline could have an important role in developing effective preventive strategies and addressing health disparities in aging populations. The overarching goal of this proposal is to examine the association of stress and cognition, role of CVD risk factors, and related health disparities. The research proposed in this Mentored Patient-Oriented Research Career Development Award includes data analyses involving two cohort studies and determining the feasibility of a pilot clinical trial. The plan describes three separate but interrelated projects designed to examine the association of perceived stress and cognition. Specific Aim-1: The study will prospectively examine the relationship between perceived stress and incident cognitive impairment among African Americans and Whites in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort (n=30,239) and explore if CVD risk factors mediate this relationship. Specific Aim-2: The study will assess the relationship of perceived stress with specific cognitive domains among African Americans and Whites with Mild Cognitive Impairment in the Vascular Contributors to Prodromal Alzheimer's disease (VASCULAR) cohort study (n=341) at Emory. Specific Aim-3: The study will determine the feasibility of a novel web-based multidisciplinary stress reduction program and assess the program's effects on perceived stress, related biomarkers, and cognition among African Americans and Whites with Mild Cognitive Impairment (n=30). Candidate: The candidate (Dr. Kulshreshtha) is a board certified Family Physician in the Department of Family and Preventive Medicine at Emory University. His long-term career goal is to become an independent clinician researcher investigating the mechanisms of behavioral and lifestyle interventions to improve cognitive health and reduce health disparities. The integrated research and training program described in this proposal will build on the candidate's prior experience in cardiovascular epidemiology, health disparities, and primary care clinical work. It will incorporate new training in cognitive and stress measurements, and clinical trials, to develop expertise in the area of stress and cognition research for AD prevention. Overall this research will form the basis for larger studies investigating potential mechanisms and interventions for AD prevention and establish Dr. Kulshreshtha as a young investigator in patient-oriented clinical research.

项目/摘要 非裔美国人患阿尔茨海默病（AD）的可能性是白人的两倍，但很少有研究表明， 关注这些认知差异和相关机制。少数群体的压力感知，如 非裔美国人，直接影响认知，也在心血管疾病危险因素的恶化中发挥作用， 不健康的行为，如吸烟、不适当的饮食和缺乏体育活动。进一步了解 可改变的风险因素，如认知能力下降中的感知压力，可能在发展中发挥重要作用。 有效的预防战略和解决老龄人口的健康差距。总体目标 这项建议的目的是研究压力和认知的关系，心血管疾病危险因素的作用，以及相关的 健康差距。本研究中提出的研究指导病人为导向的研究职业发展 该奖项包括涉及两项队列研究的数据分析，并确定试点临床试验的可行性。 该计划描述了三个独立但相互关联的项目，旨在研究人们所认为的 压力和认知。 具体目标1：本研究将前瞻性地探讨知觉压力与事件之间的关系 非裔美国人和白人认知障碍的地理和种族原因 卒中（REGARDS）队列（n= 30，239）的差异，并探讨CVD风险因素是否介导了这种关系。 具体目标-2：本研究将评估感知压力与特定认知领域的关系 在患有轻度认知障碍的非裔美国人和白人中， 在Emory进行的前驱阿尔茨海默病（血管性）队列研究（n=341）。 具体目标3：该研究将确定一种新的基于网络的多学科减压方法的可行性。 计划并评估该计划对感知压力，相关生物标志物和认知的影响， 轻度认知障碍的非裔美国人和白人（n=30）。 候选人：候选人（Kulshreshtha博士）是家庭部的一名委员会认证家庭医生 和预防医学。他的长期职业目标是成为一名独立的临床医生 研究行为和生活方式干预机制以改善认知健康的研究人员 减少健康差距。本建议书所述的综合研究和培训方案将 以候选人在心血管流行病学、健康差异和初级保健方面的经验为基础 临床工作。它将包括认知和压力测量方面的新培训以及临床试验， 发展在压力和认知研究领域的专业知识，以预防AD。总的来说，这项研究将形成 研究AD预防的潜在机制和干预措施的大型研究的基础， 使Kulshreshtha博士成为以患者为导向的临床研究的年轻研究者。