Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers

这是杰奎琳·伊顿博士的K 01奖申请，她是一位老年病学家，也是一位年轻的研究者， 关于通过艺术提高老年人及其照顾者生活质量的跨学科研究， 基于干预。K 01奖将为她提供在四个关键职业中获得关键技能的途径 发展领域：1）使用NIH阶段模型的行为干预研究; 2）阿尔茨海默病 和相关痴呆症（ADRD）; 3）应用多层次增长模型; 4）跨学科团队领导 以及干预研究的管理技能。通过获得这些技能，伊顿博士将实现她的职业目标， 成为独立的学术研究者和国家领导人在艺术为基础的干预研究 专注于ADRD护理人员。为了支持这一目标，伊顿博士组建了李博士的指导团队。 艾灵顿（初级导师），一个研究心理学家谁领导复杂的，多地点的临床护理研究， 和Julene约翰逊（共同导师），认知神经科学家，在开发基于艺术的 对老年人的干预。她还组建了一个三人咨询委员会， NIH阶段模型、ADRD模型和多级生长模型。 据估计，到2050年，1380万美国人将患有痴呆症，高达90%的人将 经历行为症状，如激动、好斗和抑郁。行为症状 与照顾者的更大压力有关，这导致健康状况不佳，生活质量下降， 增加了负担。有必要找到有效的干预措施，以解决行为的负面影响， 症状该提案的重点是开发和测试加强积极照顾者培训（EnACT） 帮助护理人员更好地管理与ADRD相关的常见行为症状。使用NIH 阶段模型，我们将创建（阶段1a）和进行初步测试（阶段1b），这些技术在一个 团体干预通过追求以下具体目标，伊顿博士将开发和测试EnACT， 用于第3阶段临床试验（在K 01授予期间在R 01申请中提出）。具体目标1 将为ADRD护理人员制定并反复完善EnACT干预措施。第2章评价 EnACT干预措施的可行性和可接受性。具体目标3将审查潜在机制 随时间的变化及其对近端和远端结局的后续影响。 为老龄化人口提供最佳支持所需的护理人员数量有所增加， 对地方和国家资源有更大的需求和影响。伊顿博士的研究计划是 重要的是，有效的循证干预措施需要采取系统的方法， 护理人员培训已被证明可以改善ADRD护理人员的结局。拟议的研究是 创新，因为它结合了各种学科的技术，以提高参与度和增强 我们对护理人员干预措施中的作用机制的理解。

This is a K01 award application for Dr. Jacqueline Eaton, a gerontologist and young investigator pursuing transdisciplinary research on enhancing the quality of life of older adults and their caregivers through arts- based interventions. A K01 award will provide her with the means to acquire critical skills in four key career development areas: 1) behavioral intervention research using the NIH Stage Model; 2) Alzheimer’s Disease and related dementias (ADRD); 3) applied multilevel growth modeling; and 4) interdisciplinary team leadership and management skills for intervention research. By gaining these skills, Dr. Eaton will fulfill her career goal of becoming an independent academic investigator and national leader in arts-based intervention research focused on ADRD caregivers. Supporting this goal, Dr. Eaton has assembled the mentoring team of Drs. Lee Ellington (Primary Mentor), a research psychologist who leads complex, multi-site clinical caregiver studies, and Julene Johnson (Co-Mentor), a cognitive neuroscientist with expertise in developing arts-based interventions for older adults. She has also assembled a three person Advisory Committee with expertise in the NIH Stage Model, ADRD caregiving, and multilevel growth modeling. It is estimated that by 2050, 13.8 million Americans will be living with dementia and up to 90% will experience behavioral symptoms, such as agitation, combativeness, and depression. Behavioral symptoms are associated with greater stress for caregivers, which leads to poor health, decreased quality of life, and increased burden. There is a need to find effective interventions to address the negative effects of behavioral symptoms. This proposal focuses on developing and testing the Enhancing Active Caregiver Training (EnACT) to help caregivers better manage the common behavioral symptoms associated with ADRD. Using the NIH Stage Model, we will create (Stage 1a) and conduct preliminary testing (Stage 1b) of these techniques in a group intervention. By pursuing the following specific aims, Dr. Eaton will develop and test EnACT to prepare for a stage 3 clinical trial (to be proposed in an R01 application during the K01 award period). Specific Aim 1 will develop and iteratively refine the EnACT intervention for ADRD caregivers. Specific Aim 2 will evaluate the feasibility and acceptability of the EnACT intervention. Specific Aim 3 will examine potential mechanisms of change over time and their subsequent impact on proximal and distal outcomes. There is a rise in the number of caregivers required to give optimal support to an aging population that will have a greater need for, and impact on, local and national resources. Dr. Eaton’s proposed research is significant because effective evidence-based interventions require systematic approaches to enhance active caregiver training which has been shown to improve outcomes for ADRD caregivers. The proposed research is innovative because it combines techniques from a variety of disciplines to increase engagement and enhance our understanding of mechanisms of action within caregiver interventions.