Administrative Core

项目概要/摘要-行政核心 这种创新的综合系统生物学应用旨在进一步描绘复杂的宿主/病原体 在肺泡水平发生的相互作用导致严重肺炎治疗无效。 该中心是多学科的，增加了相互作用的复杂性 并授权一个集中的方法，以促进实现这个系统生物学中心的目标。的 T2系统生物学中心研究议程的主要前提是一种迭代方法， 基于高通量组学方法和数学建模结果的宿主/病原体相互作用 的结果。因此，我们希望先前的结果将推动后续的实验。整合和便利 不同的核心和研究人员之间的这些后续实验的主要责任将是 行政核心。行政核心还将确保项目和核心产生的数据 以有益于广大肺炎和传染病社区的形式传播 研究人员行政核心将通过四个具体目标实现这些目标： 目标1.支持项目调查员、核心领导人和其他U19系统之间的沟通 生物中心研究员和NIAID计划工作人员。行政核心将负责 协调整个中心活动范围内的沟通，包括与 与其他U19中心和NIH/NIAID项目工作人员一起进行的多学科研究。 目标二。提供一个分配共同资源和传播 信息，以及监管监督和预算及人力资源管理， 项目调查员和核心领导人。我们期望先前的建模结果将推动后续的分析 或数据/样本收集。整合和促进不同核心之间的后续分析 调查员将是行政核心的主要责任。 目标3.通过出版物传播项目调查员的发现， 向其他机构和研究者进行演示，并分享材料和原始数据，包括 通过NIAID指导的公共数据库/存储库。我们致力于使我们的数据可查找， 可扩展、可互操作和可重用（FAIR）。 目标4。促进本地和外部跨学科合作研究的环境， 指导受训人员推广系统生物学方法治疗肺炎、其他传染病， 和其他严重疾病。我们相信，在EST 2系统生物学多组学和数学 严重肺炎的建模方法与其他感染和其他危重疾病相关。管理员 核心将组织一系列地方和外联活动，以促进这种做法。

Project Summary/Abstract – Administrative Core This innovative integrated systems biology application seeks to further delineate the complex host/pathogen interactions occurring at the alveolar level that lead to unsuccessful response to therapy in serious pneumonia. The SCRIPT2 Systems Biology Center is intentionally multidisciplinary, increasing the complexity of interactions and mandating a centralized approach to facilitate accomplishing the goals of this Systems Biology Center. The major premise of the SCRIPT2 Systems Biology Center research agenda is an iterative approach to host/pathogen interactions based on results of high throughput omics approaches and mathematical modeling of the results. We therefore expect that prior results will drive subsequent experiments. Integration and facilitation of these subsequent experiments between the different Cores and investigators will be the primary responsibility of the Administrative Core. The Administrative Core will also ensure that data generated by the Projects and Cores are disseminated in formats that are useful to the larger community of pneumonia and infectious diseases researchers. The Administrative Core will accomplish these objectives in four specific aims: Aim 1. To support communication between Project Investigators, Core Leaders, other U19 Systems Biology Center Investigators, and NIAID Program Staff. The Administrative Core will be responsible for coordinating communication across the entire range of Center activities, including internal relationships with the multidisciplinary SCRIPT2 investigators, with other U19 Centers, and with NIH/NIAID program staff. Aim 2. To provide a structure for the distribution of common resources and the dissemination of information, as well as regulatory oversight and budgetary and personnel resource management, to the Project Investigators and Core Leaders. We expect that prior modeling results will drive subsequent analyses or data/sample collection. Integration and facilitation of these subsequent analyses between the different Cores and investigators will be the primary responsibility of the Administrative Core. Aim 3. To disseminate the discoveries made by Project Investigators through publications, presentations, and the sharing of materials and raw data to other institutions and investigators, including via NIAID-directed public databases/repositories. We are committed to making our data Findable, Accessible, Interoperable, and Reusable (FAIR). Aim 4. To foster a local and external environment of collaborative interdisciplinary research and mentoring of trainees to promote a systems biology approach to pneumonia, other infectious diseases, and other critical illnesses. We believe that the SCRIPT2 Systems Biology multi-omics and mathematical modeling approach to severe pneumonia is pertinent to other infections and other critical illnesses. The Admin Core will organize a suite of local and outreach activities to foster this approach.