Varicella-Zoster Virus: T Cell/Skin Tropisms & Immunity

水痘带状疱疹病毒：T 细胞/皮肤趋向性

• 批准号: 10552532
• 负责人: Stefan Lyne Oliver
• 金额: $ 39.38万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10552532
• 关键词: Address; Adult; Amino Acids; Axonal Transport; Binding; Cell Surface Receptors; Cell Survival; Cell fusion; Cells; Chickenpox; Chinese Hamster Ovary Cell; Complement; Complement Activation; Complement Membrane Attack Complex; Complex; Cytolysis; Elements; Equilibrium; Event; Exanthema; Gel; Genes; Glycoproteins; Grant; HSV glycoprotein C; Hematogenous; Herpes zoster disease; Herpesviridae; Herpesvirus 1; Herpesvirus Type 3; Human; Immune response; Immunity; Immunoprecipitation; In Vitro; Incubated; Infection; Inflammasome; Instruction; Knowledge; Libraries; Life Cycle Stages; Maps; Mass Spectrum Analysis; Mediating; Membrane; Methods; Molecular; Mutation; Neurons; PI3 gene; Pathogenesis; Phosphorylation; Phosphotransferases; Platelet-Derived Growth Factor Receptor; Production; Proteins; Receptor Cell; Recovery; Regulation; Reporting; Research; Respiratory System; Role; SCID Mice; Second Messenger Systems; Sensory; Sensory Ganglia; Sepharose; Serum; Signal Pathway; Signal Transduction; Site; Skin; T-Lymphocyte; Testing; Tissues; Tonsil; Transfection; Tropism; Viral; Viral Genes; Viral Pathogenesis; Viral Proteins; Virion; Virus; Virus Diseases; Virus Replication; Work; cancer cell; cancer type; candidate identification; complement system; defined contribution; design; experimental study; genetic regulatory protein; immunodeficient mouse model; inhibiting antibody; innovation; insight; knock-down; mouse model; pathogenic virus; programs; promoter; protein activation; protein kinase R; receptor; receptor binding; recombinant virus; skin xenograft; virus tropism

Varicella-zoster virus is an alpha-herpesvirus that causes varicella and zoster. Infection of T cells allows VZV transfer from the respiratory tract to skin and the typical herpes zoster rash results from axonal transport after VZV reactivation in neurons. Our research program investigates the mechanisms of VZV take-over of its target cells, focusing on infection of primary human tonsil T cells and adult skin xenografts in the severe combined immunodeficiency (SCIO) mouse model. We plan to pursue our longstanding objective to understand of VZV pathogenesis in new directions that are designed to determine the role of activation of protein kinase R in VZV infection, the effects of complement as an innate defense against VZV infection of tonsil T cells and VZV countermeasures, and glycoprotein-mediated mechanisms of VZV entry into T cells. This work is expected to provide new knowledge about the takeover of host cell signaling pathways by VZV to support its replication, the regulation of VZV pathogenesis by innate host responses and how VZV overcomes these barriers, and the functions of VZV glycoproteins during infection of differentiated human cells, all of which are critical for VZV infection of the human host. RELEVANCE (See instructions):

水痘-带状疱疹病毒是一种引起水痘和带状疱疹的阿尔法疱疹病毒。T细胞的感染允许 VZV从呼吸道传播到皮肤，典型的带状疱疹由轴突引起 VZV重新激活后在神经元中的转运。我们的研究项目是研究VZV的发病机制 接管其靶细胞，专注于原代人类扁桃体T细胞和成人异种皮肤移植的感染 在严重联合免疫缺陷(SCIO)小鼠模型中。我们计划继续我们的长期合作 目的了解VZV致病机理的新方向，旨在确定其作用机制 蛋白激酶R在VZV感染中的激活以及补体作为一种天然防御机制对VZV的影响 扁桃体T细胞感染VZV及VZV对策及糖蛋白介导的VZV机制 进入T细胞。这项工作有望为宿主细胞的接管提供新的知识 VZV支持其复制的信号通路，天然宿主对VZV致病的调控 VZV的应答和如何克服这些障碍，以及VZV糖蛋白在 分化的人类细胞的感染，所有这些都是人类宿主感染VZV的关键。 相关性(请参阅说明)：

项目成果

Varicella zoster virus ORF25 gene product: an essential hub protein linking encapsidation proteins and the nuclear egress complex.

• DOI: 10.1021/pr200628s
• 发表时间: 2011-12-02
• 期刊: JOURNAL OF PROTEOME RESEARCH
• 影响因子: 4.4
• 作者: Pinto, Maria G. Vizoso;Pothineni, Venkata R.;Haase, Rudolf;Woidy, Mathias;Lotz-Havla, Arnelie S.;Gersting, Soren W.;Muntau, Ania C.;Haas, Juergen;Sommer, Marvin;Arvin, Ann M.;Baiker, Armin
• 通讯作者: Baiker, Armin

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion.

• DOI: 10.1371/journal.ppat.1008961
• 发表时间: 2021-01
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Oliver SL;Xing Y;Chen DH;Roh SH;Pintilie GD;Bushnell DA;Sommer MH;Yang E;Carfi A;Chiu W;Arvin AM
• 通讯作者: Arvin AM

Regulation of the ORF61 promoter and ORF61 functions in varicella-zoster virus replication and pathogenesis.

ORF61 启动子的调节和 ORF61 在水痘带状疱疹病毒复制和发病机制中的功能。

• DOI: 10.1128/jvi.00118-09
• 发表时间: 2009
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Wang,Li;Sommer,Marvin;Rajamani,Jaya;Arvin,AnnM
• 通讯作者: Arvin,AnnM

Tumor necrosis factor, interleukin-2, and interferon-gamma in adult varicella.

成人水痘中的肿瘤坏死因子、白细胞介素 2 和干扰素 γ。

• DOI: 10.1002/jmv.1890430113
• 发表时间: 1994
• 期刊: Journal of medical virology
• 影响因子: 12.7
• 作者: Wallace,MR;Woelfl,I;Bowler,WA;Olson,PE;Murray,NB;Brodine,SK;Oldfield3rd,EC;Arvin,AM
• 通讯作者: Arvin,AM

T-cell tropism and the role of ORF66 protein in pathogenesis of varicella-zoster virus infection.

T 细胞趋向性和 ORF66 蛋白在水痘带状疱疹病毒感染发病机制中的作用。

• DOI: 10.1128/jvi.79.20.12921-12933.2005
• 发表时间: 2005
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Schaap,Anne;Fortin,Jean-Francois;Sommer,Marvin;Zerboni,Leigh;Stamatis,Shaye;Ku,Chia-Chi;Nolan,GarryP;Arvin,AnnM
• 通讯作者: Arvin,AnnM