Chemosensation of death conspecifics modulates neural signaling and lifespan in Caenorhabditis elegans
Chemosensation of death conspecifics modulates neural signaling and lifespan in Caenorhabditis elegans
批准号:
10553123
负责人:
Mirella Hernandez
金额:
$2.22万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-05-01 至 2023-09-28
关键词:
AddressAdultAffectAfferent NeuronsAgingAnimalsBehaviorBehavioralBiologicalCaenorhabditis elegansCalciumCalcium ChannelCessation of lifeCuesDataDetectionEnvironmentEsthesiaExposure toFoundationsFunctional ImagingFutureG Protein-Coupled Receptor SignalingG-Protein-Coupled ReceptorsGTP-Binding ProteinsGeneticGoalsGuanylate CyclaseHeadHealthHermaphroditismHumanImageInterneuronsInvertebratesKnowledgeLengthLongevityMammalsMediatingMembraneMentorsModelingMolecularMonitorMotor NeuronsNematodaNervous SystemNeuronsNeurotransmittersOutputPerceptionPerfusionPhysiologicalPositioning AttributeProcessPublishingQuality of lifeRNA InterferenceRegulationResearchRoleSensorySignal PathwaySignal TransductionTaxesTranslatingVanilloidWorkavoidance behaviorcyclic-nucleotide gated ion channelsdesignexperimental studyfollow-upgenetic approachhealthspanimaging approachimprovedinsightmutantnegative affectneural circuitneuromechanismneurotransmissionnew therapeutic targetnovel strategiesreceptorresponsesensory integrationsensory systemtherapy development
中文摘要
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英文摘要
PROJECT ABSTRACT
All animals rely on sensory systems to detect and respond to environmental and behavioral cues. In most
animals, this sensory information is perceived and processed by different sensory neurons, allowing animals to
respond appropriately to maximize health- and lifespan. However, a detailed understanding of the underlying
cues and mechanisms by which the sensory nervous system regulates lifespan and aging remains largely
unknown. Addressing these gaps in knowledge is imperative to obtain a comprehensive understanding of the
impact of sensory perception on lifespan regulation. The goal of my project is to identify the neurons and
signaling mechanisms by which the perception of dead conspecifics regulates behavior and lifespan in
Caenorhabditis elegans. My preliminary work using C. elegans shows that exposure to dead conspecifics
result in 1) aversive behavior and 2) shortened lifespan. My studies also suggest that dead conspecifics
release “death cues” that are detected by olfactory neurons. My central hypothesis is that detection of
intracellular metabolites released by dead conspecifics are recognized by amphid olfactory neurons AWB
and/or ASH, promoting a GPCR-dependent signaling cascade leading to the observed aversive behavior and
lifespan shortening. The objective of Aim 1 is to identify the sensory, inter-, and motor neurons required and
sufficient for death perception in C. elegans. Aim 2 will define the molecular mechanisms translating death
perception to behavioral changes and shortened lifespans. The proposed research will provide new
fundamental knowledge into the role of sensory perception in the regulation of aging. This may represent the
first step towards uncovering novel therapeutic targets capitalizing on the sensory perception – aging
relationship.
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Perception of Dead Conspecifics modulates neural signaling and lifespan in Caenorhabditis elegans
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批准号:10828478
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项目类别:
-
资助金额:$4.18万
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财政年份:2023
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负责人:Mirella Hernandez
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依托单位:
海外基金