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Data Sciences Core

数据科学核心

基本信息

批准号：
10553990
负责人：
Bonnie LaFleur
金额：
$ 18.32万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2028-02-29
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10553990
关键词：
Address Aging Algorithms Benchmarking Bioconductor Bioinformatics Biological Biometry Categories Cell Aging Cells Code Collaborations Computational Biology Data Data Analyses Data Provenance Data Science Core Data Set Development Documentation Ensure Environment Experimental Designs Flow Cytometry Formulation Fostering Goals Human Immune Immune response In Vitro Infrastructure Knowledge Management Maps Measures Metadata Methodology Methods Modernization Mus Pathway Analysis Performance Peripheral Rejuvenation Reproducibility Research Research Design Research Personnel Research Project Grants Role Sample Size Scientist Specialist Standardization Statistical Computing Statistical Methods Structure T-Lymphocyte Technology Testing Thymus Gland Update Viral Work cyber infrastructure data and analysis portal data harmonization data integration data management data quality data repository design differential expression experimental analysis experimental study high throughput technology improved method development multimodality novel programs repository single cell analysis single-cell RNA sequencing sound statistics tool web based interface

项目摘要

CORE B- Abstract The Data Sciences Core (Core B) will provide professional expertise in statistics, bioinformatics, and computing to all projects, cores, and investigators in this “Thymic and peripheral aspects of T cell aging and rejuvenation” Program Project (Program). Core B will provide biostatistics design and analysis for all mouse and in vitro studies across Program, including formulation of testable hypotheses, estimation of sample size and power, performance and interpretation of data analyses, and graphical display and interpretation of results. In addition, the core will provide bioinformatics expertise and analysis for the the scRNA-Seq profiling experiments in P1 – P3 and Core C. This support will include data quality checks, read mapping and normalization, differential expression analysis, and pathway analysis to identify subsets of cells impacting specific functions or cellular mechanisms. Core B statistical scientists make extensive use of modern methods of statistical computing and reproducible research tools. This capability fosters the sharing of analysis code and results, the rapid deployment of novel analysis tools, and effective investigator access to program-wide data and knowledge management platforms for cross-project research discovery. Core B is a vital component of each Project and will facilitate the discovery of novel scientific results in immune aging.

核心B-摘要数据科学核心（核心B）将提供统计学、生物信息学和计算的所有项目，核心，和调查人员在这个“胸腺和外周方面的T细胞老化和复兴”计划项目（Program）。核心B将提供所有小鼠的生物统计学设计和分析和整个项目的体外研究，包括可检验假设的制定、样本量的估计数据分析的功效、性能和解释，以及结果的图形显示和解释。此外，该核心将为scRNA-Seq分析提供生物信息学专业知识和分析。 P1 - P3和Core C中的实验。这种支持将包括数据质量检查、读取映射和标准化，差异表达分析和途径分析，以鉴定影响细胞的亚群，特定功能或细胞机制。核心B统计科学家广泛使用现代方法统计计算和可重复的研究工具。这种能力促进了分析代码的共享新的分析工具的快速部署，以及有效的调查人员访问整个项目跨项目研究发现的数据和知识管理平台。核心B是一个重要的组成部分这将有助于发现免疫衰老方面的新科学成果。