Data Sciences Core

核心B-摘要 数据科学核心(核心B)将提供统计、生物信息学和 计算到所有项目，核心，和研究人员在这个“胸腺和外周方面的T细胞老化和 “振兴”计划项目(计划)。核心B将为所有小鼠提供生物统计设计和分析 和跨计划的体外研究，包括可检验假设的形成，样本量的估计 以及数据分析的能力、性能和解释，以及结果的图形显示和解释。 此外，该核心将为scRNA-Seq图谱提供生物信息学专业知识和分析 在P1-P3和Core C中进行实验。该支持将包括数据质量检查、读取映射和 标准化、差异表达分析和路径分析以确定影响细胞亚群 特定的功能或细胞机制。B级核心统计科学家广泛使用现代方法 统计计算和可重复使用的研究工具。这种能力促进了分析代码的共享 和结果，快速部署新的分析工具，以及有效的调查人员访问整个计划 跨项目研究发现的数据和知识管理平台。核心B是一个至关重要的组成部分 并将促进在免疫衰老方面发现新的科学结果。

CORE B- Abstract The Data Sciences Core (Core B) will provide professional expertise in statistics, bioinformatics, and computing to all projects, cores, and investigators in this “Thymic and peripheral aspects of T cell aging and rejuvenation” Program Project (Program). Core B will provide biostatistics design and analysis for all mouse and in vitro studies across Program, including formulation of testable hypotheses, estimation of sample size and power, performance and interpretation of data analyses, and graphical display and interpretation of results. In addition, the core will provide bioinformatics expertise and analysis for the the scRNA-Seq profiling experiments in P1 – P3 and Core C. This support will include data quality checks, read mapping and normalization, differential expression analysis, and pathway analysis to identify subsets of cells impacting specific functions or cellular mechanisms. Core B statistical scientists make extensive use of modern methods of statistical computing and reproducible research tools. This capability fosters the sharing of analysis code and results, the rapid deployment of novel analysis tools, and effective investigator access to program-wide data and knowledge management platforms for cross-project research discovery. Core B is a vital component of each Project and will facilitate the discovery of novel scientific results in immune aging.