Data Science (DS) Core B

数据科学 (DS) 核心 B

• 批准号: 10491849
• 负责人: Bonnie LaFleur
• 金额: $ 59.15万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10491849
• 关键词: Aging; Area; Bioinformatics; Biological Assay; Biological Markers; Biological Sciences; Biometry; Classification; Code; Cognition; Cognitive; Collaborations; Custom; Data; Data Aggregation; Data Analyses; Data Collection; Data Science Core; Data Set; Data Storage and Retrieval; Databases; Ensure; Formulation; Foundations; Funding; Genomics; Goals; Good Clinical Practice; Heterogeneity; Human; Image; Individual; Knowledge; Link; Literature; Longevity; Machine Learning; Manuscripts; Methods; Modality; Modeling; Molecular Profiling; Monitor; Participant; Procedures; PubMed; Public Domains; Publications; Publishing; Reporting; Reproducibility; Research; Research Project Grants; Risk; Sample Size; Science; Scientist; Secure; Site; Statistical Data Interpretation; System; Technology; Testing; Theoretical model; Time; Update; Visual; Work; analytical method; base; biobank; brain health; cognitive function; cognitive testing; cohort; collaboratory; community engagement; computer infrastructure; computer program; dashboard; data management; data reduction; data sharing; data visualization; design; experience; genomic tools; healthspan; knowledge base; large scale data; machine learning method; member; multimodality; neuroimaging; novel; open data; precision medicine; predictive modeling; recruit; repository; statistical and machine learning; terabyte; text searching; tool

SUMMARY/ABSTRACT: Data Science Core B The objectives of the Data Science (DS) Core are to provide centralized data management, data sharing tools, and quantitative methods to support all analysis needs for research Projects and Cores. The DS Core will also provide a mechanism to develop novel methods to facilitate our long-term PAN goals of harnessing the power of precision medicine to predict individual brain health risks and discover personalized solutions to better match human lifespan with cognitive healthspan. Core scientists will provide support for design and analyses for all Projects, including formulation of testable hypotheses, estimation of sample size and power, multivariate and multivariable classification/prediction analyses and graphical display and interpretation of results. In addition, the Core will provide expertise in bioinformatic approaches that can be used in Projects 1, 2 and 4, as well as Cores E and G. The DS Core is a vital component of each research project in this application through data management as well as the conduit for specific analyses from both Projects 1 and 2 and the foundation for the overall synthesis of the genomic, cognitive function testing, biomarkers, and imaging data for all PAN research.

总结/摘要：数据科学核心B 数据科学（DS）核心的目标是提供集中的数据管理，数据共享， 工具和定量方法，以支持研究项目和核心的所有分析需求。DS核心 还将提供一种机制，开发新的方法，以促进我们的长期PAN目标， 精准医学预测个体大脑健康风险并发现个性化 更好地匹配人类寿命与认知健康的解决方案。核心科学家将提供支持 用于所有项目的设计和分析，包括制定可检验的假设，估计样本量 以及功效、多变量和多变量分类/预测分析和图形显示， 结果的解释。此外，核心将提供生物信息学方法方面的专业知识， 用于项目1、2和4以及核心E和G。DS核心是每个研究的重要组成部分 项目在此应用程序中通过数据管理以及管道的具体分析， 项目1和2以及基因组整体合成的基础，认知功能测试， 生物标志物和所有PAN研究的成像数据。