Core D: Integrated Computational Analysis Core
Core D: Integrated Computational Analysis Core
批准号:
10555896
负责人:
Vilas Menon
金额:
$92.59万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-09-30 至 2028-08-31
关键词:
3-DimensionalAddressAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAnusAtlasesBlood VesselsBrainBrain MappingBrain PathologyCellsCommunitiesComputer AnalysisDataData AnalysesDerivation procedureDimensionsDiseaseEducationFeedbackGene ExpressionGenerationsGoalsHumanImageIndividualLinkMapsMeasurableModalityModelingPathologicPathologyProcessRNAReproducibilityResearch PersonnelResolutionRisk FactorsSamplingSpatial DistributionTissuesWorkage relatedaging brainbrain tissuecell typegenome-widegenomic dataimage registrationlarge scale datamultiple omicsprotein aggregationprotein expressionscale upsecondary analysisstemtranscriptomicsusability
中文摘要
综合计算分析核心:项目摘要/摘要
英文摘要
INTEGRATED COMPUTATIONAL ANALYSIS CORE: PROJECT SUMMARY/ABSTRACT
To investigate how disease relevant changes, such as Alzheimer’s disease, are linked to specific risk factors
(e.g., age-related changes, protein aggregates, vascular pathologies, etc.) to alter the spatial arrangement
of cell types in the brain and their gene expression profiles, we need to build high-resolution maps of brain
tissue at the cellular level in individuals with and without pathology. Building these maps requires proper
characterization of the pathological features, as well as a reproducible workflow for data generation and
imaging. To this end, the Integrated Computational Analysis Core will work closely with the Spatial Multiomics
Core, the Biospecimen Core, and the four Projects on all aspects of imaging and genomics data analysis.
This includes the following: 1) Primary analysis, comprising image registration, segmentation, and gene
expression quantification, 2) Secondary analysis, comprising cross-sample registration and cell type
assignment using multiplexed protein expression and genome-wide transcriptomics data, and 3) Tertiary
analysis, involving the derivation of discrete measurable attributes summarizing key aspects of cell type,
gene expression, and pathological composition and distribution in space. By scaling up and adapting existing
workflows to address these data analysis needs, this Core is centrally involved in all analysis aims of each
Project, as well as being engaged in continuous feedback with the Spatial Multiomics Core to optimize data
generation workflows. An additional goal of this core is to integrate the raw and processed data, as well as
the spatial attribute models, into a queryable, interactive portal called the Multidimensional Atlas of Aging and
Pathology in the Brain (MAAP-Brain) visualizer. This publicly accessible portal, along with dissemination of
workflows through the educational component of this overall U19 proposal, will provide the brain aging and
AD scientific community with an interface to engage with the large-scale data generated by the Projects and
other Cores. Ultimately, we aim for this dissemination effort to allow external researchers to generate or
validate their own hypotheses about changes in cellular composition and arrangement associated with aging
and human brain pathology.
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科研奖励(0)
会议论文
Project 2: 3-D Molecular atlas of AD proteinopathy
-
批准号:10555898
-
项目类别:
-
资助金额:$56.28万
-
财政年份:2023
-
负责人:Vilas Menon
-
依托单位:
Identifying cell type-specific autonomous and non-autonomous interactions in AD
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批准号:10446168
-
项目类别:
-
资助金额:$256.74万
-
财政年份:2022
-
负责人:Vilas Menon
-
依托单位:
Data Analysis Core
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批准号:10683322
-
项目类别:
-
资助金额:$36.1万
-
财政年份:2021
-
负责人:Vilas Menon
-
依托单位:
Data Analysis Core
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批准号:10385187
-
项目类别:
-
资助金额:$40.17万
-
财政年份:2021
-
负责人:Vilas Menon
-
依托单位:
Elucidating changes in astrocyte subpopulations associated with resistance to Alzheimers Disease pathology in multi-ethnic cohorts
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批准号:10334550
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项目类别:
-
资助金额:$74.51万
-
财政年份:2020
-
负责人:Vilas Menon
-
依托单位:
Elucidating changes in astrocyte subpopulations associated with resistance to Alzheimers Disease pathology in multi-ethnic cohorts
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批准号:10162469
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项目类别:
-
资助金额:$74.54万
-
财政年份:2020
-
负责人:Vilas Menon
-
依托单位:
Elucidating changes in astrocyte subpopulations associated with resistance to Alzheimers Disease pathology in multi-ethnic cohorts
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批准号:10612715
-
项目类别:
-
资助金额:$51.88万
-
财政年份:2020
-
负责人:Vilas Menon
-
依托单位:
海外基金