Core A: Administrative Core

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ADMINISTRATIVE CORE: PROJECT SUMMARY/ABSTRACT The overall theme of the “3-D Aging & Alzheimer Brain Program” is to is to define the effect of multiple pathologies on the aged brain in three dimensions by combining single cell-based approaches with spatially-resolved transcriptomic and proteomic measurements. To accomplish this goal, the Program has been organized into four cores and four research projects, each with their own individual goals whose complexity and ultimate interconnection requires careful coordination and oversight. Central to this effort is the Administrative Core (Admin Core), which will serve as the organizational hub for our Program, providing an umbrella of scientific oversight, coordination, and support for the Program activities. The Admin Core will be led by the Program Director, Dr. Philip De Jager, who will be responsible for overseeing the day-to-day operations with support from a project coordinator and an administrative assistant. Together, they will provide support for administrative and financial activities, as well as manage all internal and external communications, including those with the National Institute on Aging (NIA). To ensure scientific oversight of the Program, the Director will chair the Steering Committee, which will be composed of Core and Project Co-Leads, as well as relevant NIH staff. The experience of the Steering Committee members will be leveraged to establish a Charter and to set attainable deliverables at the onset of the Program. Additionally, the Steering Committee will meet monthly to coordinate and ensure that the overall goals of the Program are being achieved. The Steering Committee will work closely with the NIA to assemble an External Advisory Board (EAB), which will annually evaluate the Program and provide external oversight. The Admin Core will develop and implement a state-of-the art Laboratory Information Management System (LIMS) to ensure appropriate tracking of specimens and data between the Program components. The Admin Core will also be responsible for ensuring compliance with the Program’s resource sharing plan in order to maximize access to the resources generated by the Program. This will be facilitated via a collaboration with Sage Bionetworks in order to oversee distribution of all Program data and resources via the NIA-sponsored repository, AD Knowledge Portal. The Admin Core will organize a quarterly educational meeting focused on the techniques and best practices implemented via this Program. To help promote awareness of Program resources and scientific activities, the Program will participate in and host an annual research symposium and establish an outward-facing website. The Admin Core is designed to provide research and logistical oversight and facilitate communication among all Program components to enhance efficiency, reduce cost, and maintain the timely achievement of milestones. The proper dissemination of Program-generated resources to the scientific community will fill the large gap in knowledge regarding the 3-dimensional modeling of molecular events in the aging brain and the impact of neuropathological features.