Core A: Administrative Core

行政核心：项目摘要/摘要 《3-D衰老与阿尔茨海默病脑计划》的总主题是定义多种病理因素的影响 基于单细胞和空间分辨相结合的三维脑老化研究 转录和蛋白质组学测量。为了实现这一目标，该方案被分成四个部分 核心和四个研究项目，每个项目都有自己的目标，其复杂性和终极目标 互联互通需要认真的协调和监督。这项工作的核心是管理核心 (管理核心)，它将作为我们计划的组织中心，提供科学 监督、协调和支持项目活动。管理核心将由该计划领导 主任菲利普·德·雅格博士将负责监督日常运作，并得到 一名项目协调员和一名行政助理。他们将共同为管理和管理提供支持 财务活动，以及管理所有内部和外部沟通，包括与国家 老龄化研究所(NIA)。为确保对方案进行科学监督，主任将主持指导工作 该委员会将由核心和项目共同领导以及NIH的相关工作人员组成。体验 指导委员会成员将被用来制定一份宪章并设定可实现的交付成果 在该计划开始时。此外，指导委员会将每月举行会议，以协调和确保 该方案的总体目标正在实现。指导委员会将与NIA密切合作 组建一个外部顾问委员会(EAB)，该委员会将每年对该计划进行评估，并提供外部 疏忽。管理核心将开发和实施最先进的实验室信息管理 系统(LIMS)，以确保适当跟踪项目各组成部分之间的标本和数据。这个 管理核心还将负责确保遵守计划的资源共享计划，以 以最大限度地访问本计划生成的资源。这将通过与 通过NIA赞助的Sage Bionnetworks来监督所有计划数据和资源的分发 存储库、AD知识门户。管理核心将组织一次季度教育会议，重点是 通过本计划实施的技术和最佳实践。帮助提高对计划资源的认识 和科学活动，该计划将参加和主办年度研究研讨会，并建立一个 外向型网站。管理核心旨在提供研究和后勤监督，并促进 所有计划组件之间的沟通，以提高效率，降低成本，并及时维护 取得里程碑成就。将计划产生的资源适当地传播给科学工作者 社区将填补关于分子事件的三维建模方面的知识的巨大空白 脑老化对神经病理特征的影响。

ADMINISTRATIVE CORE: PROJECT SUMMARY/ABSTRACT The overall theme of the “3-D Aging & Alzheimer Brain Program” is to is to define the effect of multiple pathologies on the aged brain in three dimensions by combining single cell-based approaches with spatially-resolved transcriptomic and proteomic measurements. To accomplish this goal, the Program has been organized into four cores and four research projects, each with their own individual goals whose complexity and ultimate interconnection requires careful coordination and oversight. Central to this effort is the Administrative Core (Admin Core), which will serve as the organizational hub for our Program, providing an umbrella of scientific oversight, coordination, and support for the Program activities. The Admin Core will be led by the Program Director, Dr. Philip De Jager, who will be responsible for overseeing the day-to-day operations with support from a project coordinator and an administrative assistant. Together, they will provide support for administrative and financial activities, as well as manage all internal and external communications, including those with the National Institute on Aging (NIA). To ensure scientific oversight of the Program, the Director will chair the Steering Committee, which will be composed of Core and Project Co-Leads, as well as relevant NIH staff. The experience of the Steering Committee members will be leveraged to establish a Charter and to set attainable deliverables at the onset of the Program. Additionally, the Steering Committee will meet monthly to coordinate and ensure that the overall goals of the Program are being achieved. The Steering Committee will work closely with the NIA to assemble an External Advisory Board (EAB), which will annually evaluate the Program and provide external oversight. The Admin Core will develop and implement a state-of-the art Laboratory Information Management System (LIMS) to ensure appropriate tracking of specimens and data between the Program components. The Admin Core will also be responsible for ensuring compliance with the Program’s resource sharing plan in order to maximize access to the resources generated by the Program. This will be facilitated via a collaboration with Sage Bionetworks in order to oversee distribution of all Program data and resources via the NIA-sponsored repository, AD Knowledge Portal. The Admin Core will organize a quarterly educational meeting focused on the techniques and best practices implemented via this Program. To help promote awareness of Program resources and scientific activities, the Program will participate in and host an annual research symposium and establish an outward-facing website. The Admin Core is designed to provide research and logistical oversight and facilitate communication among all Program components to enhance efficiency, reduce cost, and maintain the timely achievement of milestones. The proper dissemination of Program-generated resources to the scientific community will fill the large gap in knowledge regarding the 3-dimensional modeling of molecular events in the aging brain and the impact of neuropathological features.