Core A: Administrative Core

核心A：行政核心

• 批准号: 10555893
• 负责人: PHILIP L DE JAGER
• 金额: $ 67.09万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555893
• 关键词: 3-Dimensional; Accounting; Achievement; Address; Aging; Alzheimer' s Disease; Alzheimer' s disease brain; Alzheimer' s disease pathology; Amyloid; Atlases; Autopsy; Awareness; Brain; Cells; Cerebral Amyloid Angiopathy; Charge; Collaborations; Committee Members; Communication; Communities; Complement; Computer Analysis; Data; Documentation; Education; Ensure; Environment; Event; Financial Activity; Freezing; Generations; Goals; Immunohistochemistry; Impaired cognition; Individual; Knowledge; Knowledge Portal; Laboratories; Leadership; Lewy Bodies; Management Information Systems; Measurement; Methodology; Methods; Molecular; National Institute on Aging; Neocortex; Participant; Pathology; Process; Production; Program Evaluation; Proteomics; Protocols documentation; Research; Research Project Grants; Resolution; Resource Sharing; Resources; Specimen; Structure; System; Techniques; Time; Tissues; United States National Institutes of Health; Visualization; Work; age effect; aging brain; brain tissue; cost; data hub; data integration; data quality; data reduction; data resource; design; experience; improved; insight; interest; meetings; molecular modeling; molecular phenotype; multidimensional data; multimodal data; multiple omics; neocortical; neuropathology; operation; program dissemination; programs; protein TDP-43; repository; research data dissemination; symposium; synergism; tau Proteins; transcriptomics; web site

ADMINISTRATIVE CORE: PROJECT SUMMARY/ABSTRACT The overall theme of the “3-D Aging & Alzheimer Brain Program” is to is to define the effect of multiple pathologies on the aged brain in three dimensions by combining single cell-based approaches with spatially-resolved transcriptomic and proteomic measurements. To accomplish this goal, the Program has been organized into four cores and four research projects, each with their own individual goals whose complexity and ultimate interconnection requires careful coordination and oversight. Central to this effort is the Administrative Core (Admin Core), which will serve as the organizational hub for our Program, providing an umbrella of scientific oversight, coordination, and support for the Program activities. The Admin Core will be led by the Program Director, Dr. Philip De Jager, who will be responsible for overseeing the day-to-day operations with support from a project coordinator and an administrative assistant. Together, they will provide support for administrative and financial activities, as well as manage all internal and external communications, including those with the National Institute on Aging (NIA). To ensure scientific oversight of the Program, the Director will chair the Steering Committee, which will be composed of Core and Project Co-Leads, as well as relevant NIH staff. The experience of the Steering Committee members will be leveraged to establish a Charter and to set attainable deliverables at the onset of the Program. Additionally, the Steering Committee will meet monthly to coordinate and ensure that the overall goals of the Program are being achieved. The Steering Committee will work closely with the NIA to assemble an External Advisory Board (EAB), which will annually evaluate the Program and provide external oversight. The Admin Core will develop and implement a state-of-the art Laboratory Information Management System (LIMS) to ensure appropriate tracking of specimens and data between the Program components. The Admin Core will also be responsible for ensuring compliance with the Program’s resource sharing plan in order to maximize access to the resources generated by the Program. This will be facilitated via a collaboration with Sage Bionetworks in order to oversee distribution of all Program data and resources via the NIA-sponsored repository, AD Knowledge Portal. The Admin Core will organize a quarterly educational meeting focused on the techniques and best practices implemented via this Program. To help promote awareness of Program resources and scientific activities, the Program will participate in and host an annual research symposium and establish an outward-facing website. The Admin Core is designed to provide research and logistical oversight and facilitate communication among all Program components to enhance efficiency, reduce cost, and maintain the timely achievement of milestones. The proper dissemination of Program-generated resources to the scientific community will fill the large gap in knowledge regarding the 3-dimensional modeling of molecular events in the aging brain and the impact of neuropathological features.

管理核心：项目总结/摘要 “3-D衰老与阿尔茨海默病大脑计划”的总体主题是定义多种病理的影响 通过结合基于单细胞的方法和空间分辨的方法， 转录组学和蛋白质组学测量。为了实现这一目标，该方案分为四个部分， 核心和四个研究项目，每个项目都有自己的目标，其复杂性和最终目标 互联互通需要认真协调和监督。这项工作的核心是行政核心 （管理核心），这将作为我们计划的组织中心，提供科学的保护伞， 监督、协调和支持计划活动。管理核心将由该计划领导 主任菲利普·德贾格尔博士将负责监督日常运作，并得到以下方面的支持： 项目协调员和行政助理。他们将共同为行政和 财务活动，以及管理所有内部和外部通信，包括与国家 老龄化研究所（NIA）。为了确保对该计划进行科学监督，主任将主持指导委员会， 委员会将由核心和项目共同负责人以及相关NIH工作人员组成。的经验 将利用指导委员会成员的能力来制定章程，并确定可实现的交付成果 在项目开始的时候。此外，指导委员会将每月举行一次会议，以协调和确保 该计划的总体目标正在实现。指导委员会将与NIA密切合作 组建外部咨询委员会（EAB），每年对该计划进行评估，并提供外部咨询。 上级要员管理核心将开发和实施最先进的实验室信息管理 系统（LIMS），以确保适当跟踪程序组件之间的标本和数据。的 管理核心还将负责确保遵守该计划的资源共享计划， 最大限度地利用该计划产生的资源。这将通过与以下方面的合作来促进： Sage Bionetworks，以监督所有计划数据和资源通过NIA赞助的 知识库、AD知识门户。管理核心将组织一次季度教育会议，重点是 通过该计划实施的技术和最佳实践。帮助提高对计划资源的认识 和科学活动，该计划将参加并主办年度研究研讨会并建立 外向型网站管理核心旨在提供研究和后勤监督，并促进 所有计划组成部分之间的沟通，以提高效率，降低成本，并保持及时 里程碑的成就。将方案产生的资源适当传播给科学界， 社区将填补知识的巨大空白，关于分子事件的三维建模， 脑老化和神经病理学特征的影响。