Neuroimmunology Core

神经免疫学核心

• 批准号: 10413101
• 负责人: PHILIP L DE JAGER
• 金额: $ 18.08万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10413101
• 关键词: Activities of Daily Living; Address; Alzheimer' s Disease; Antibodies; Antigens; Area; Astrocytes; Biological Assay; Biological Markers; Biological Models; Budgets; Cells; Cerebrospinal Fluid; Clinical; Cognitive; Collaborations; Collection; Communities; Cryopreservation; Data; Databases; Development; Disease; Evaluation; Family; Future; Genetic; Genetic Transcription; Genetic study; Human; Immune; Immune response; Immune system; Immunotherapy; Individual; Inflammation; Innate Immune System; Investigation; Leukocytes; Measures; Mediating; Mendelian randomization; Microglia; Minor; Molecular; Morphology; Myeloid Cells; Participant; Pathogenicity; Pathologic; Pathology; Pathway interactions; Patients; Peripheral; Peripheral Blood Mononuclear Cell; Phagocytes; Play; Population; Predisposition; Process; Proteins; Proteome; Proxy; Research; Research Design; Research Personnel; Resources; Role; Sampling; Science; Stimulus; Structure; Surrogate Markers; Testing; Universities; age related; base; biobank; cell bank; data exchange; data resource; design; endophenotype; immune function; monocyte; neuroimaging; neuroimmunology; novel; prevent; programs; recruit; response; transcriptome; transcriptome sequencing

NEUROIMMUNOLOGY CORE PROJECT SUMMARY/ABSTRACT The Columbia University ADRC’s Neuroimmunology (Neuroimm) Core supports the development of biosample and data resources along one of the three thematic axes of the ADRC. Characterizing immune responses is an important component of AD investigations, but these responses are not solely responsible for the disease. Thus, it is important to integrate thoughtful, informed study design, specialized resources as well as emerging experimental and analytic pipelines for systematic immune function characterization with existing biomarker, genetic, neuroimaging and other resources to assemble a comprehensive approach to AD investigations. Our understanding of the role of the immune system in AD is rapidly evolving, and innate immune cells appear to play a key role. Thus, we propose to: (1) create a new sample resource by cryopreserving CSF cells from each recruited subject, (2) create new assays that measure surrogate markers of microglia in CSF, (3) assess the systemic state of inflammation in each of the sampled subjects, and (4) estimate the functional capacity of each individual’s microglia to respond to key stimuli. Thus, we will generate novel sample, assay, and data resources with which to accelerate the characterization of the immune system in AD.

神经免疫学核心项目总结/摘要 哥伦比亚大学ADRC的神经免疫学（Neuroimm）核心支持开发 生物样本和数据资源沿着ADRC的三个主题轴之一。表征免疫 回应是反倾销调查的一个重要组成部分，但这些回应不仅仅是负责 这种疾病因此，重要的是要整合周到，知情的研究设计，专业资源以及 用于系统免疫功能表征的新兴实验和分析管道， 生物标志物、遗传学、神经影像学和其他资源，以汇集AD的综合方法 调查事务所我们对免疫系统在AD中的作用的理解正在迅速发展，先天性免疫系统在AD中的作用也在迅速发展。 细胞似乎起着关键作用。因此，我们建议：（1）通过冷冻保存CSF来创建新的样本资源 细胞，（2）创建测量CSF中小胶质细胞的替代标志物的新测定， (3)评估每个抽样受试者的全身炎症状态，以及（4）估计功能性 每个人的小胶质细胞对关键刺激做出反应的能力。因此，我们将产生新的样品，测定， 和数据资源，以加速AD中免疫系统的表征。