Neuroimmunology Core

神经免疫学核心项目摘要/摘要 哥伦比亚大学ADRC的神经免疫学(Neuroimm)核心支持 生物样本和数据资源沿着红十字和红新月会的三个主题轴之一。免疫的特征 答复是AD调查的一个重要组成部分，但这些答复并不是唯一负责的 这种疾病。因此，重要的是整合深思熟虑、知情的研究设计、专业资源以及 用于系统免疫功能表征的新兴实验和分析管道 生物标记物、遗传、神经成像和其他资源，以汇集全面的AD治疗方法 调查。我们对免疫系统在阿尔茨海默病中的作用的了解正在迅速演变，而且先天免疫 细胞似乎扮演着关键角色。因此，我们提出：(1)通过超低温保存脑脊液建立新的标本资源 来自每个招募对象的细胞，(2)创建新的检测方法来测量脑脊液中小胶质细胞的替代标记物， (3)评估每个样本受试者的全身炎症状态，以及(4)评估功能性 每个个体的小胶质细胞对关键刺激做出反应的能力。因此，我们将生成新的样本、化验 和数据资源，用来加速AD免疫系统的特征。

NEUROIMMUNOLOGY CORE PROJECT SUMMARY/ABSTRACT The Columbia University ADRC’s Neuroimmunology (Neuroimm) Core supports the development of biosample and data resources along one of the three thematic axes of the ADRC. Characterizing immune responses is an important component of AD investigations, but these responses are not solely responsible for the disease. Thus, it is important to integrate thoughtful, informed study design, specialized resources as well as emerging experimental and analytic pipelines for systematic immune function characterization with existing biomarker, genetic, neuroimaging and other resources to assemble a comprehensive approach to AD investigations. Our understanding of the role of the immune system in AD is rapidly evolving, and innate immune cells appear to play a key role. Thus, we propose to: (1) create a new sample resource by cryopreserving CSF cells from each recruited subject, (2) create new assays that measure surrogate markers of microglia in CSF, (3) assess the systemic state of inflammation in each of the sampled subjects, and (4) estimate the functional capacity of each individual’s microglia to respond to key stimuli. Thus, we will generate novel sample, assay, and data resources with which to accelerate the characterization of the immune system in AD.