Core A: Biostatistics and Computational Biology Core

项目摘要/摘要(核心A，生物统计学和计算生物学核心) 生物统计和计算生物学(BCB)核心提供全面的专业支持，以确保 统计完整性，包括研究设计、算法选择和实施、数据完整性 整个研究周期、内部和外部数据共享以及研究的数据分析/解释 由密歇根大学孢子进行，题为分子靶向局部放射增敏 晚期癌症。核心协助调查人员进行适当的实验计划和选择 技术，协助实验室实验和临床数据的信息管理 由孢子项目生成，并近距离进行严格的生物统计和生物信息学分析 与孢子调查员合作。BCB核心成员具有不同的专业知识和 经验。核心领导人Schipper博士和Rao博士得到了教职员工和分析人员的协助 具有支持孢子活动所需专业知识的程序员。核心将支持数据流 以及在孢子内以及与孢子外的实体一起仓储。两位领导人都是一体化的 进入密歇根大学罗杰尔癌症中心的生物统计和生物信息学基础设施，以及 他们可以根据需要呼吁额外的援助，以支持对该孢子的进化研究。核心拥有 使人员与现有和发展中的孢子项目的需要相匹配的灵活性。

PROJECT SUMMARY/ABSTRACT (CORE A, BIOSTATISTICS AND COMPUTATIONAL BIOLOGY CORE) The Biostatistics and Computational Biology (BCB) Core provides comprehensive professional support to ensure statistical integrity, including study design, algorithm selection and implementation, data integrity across the entire research cycle, internal and external data sharing, and data analysis/interpretation of the studies performed by the University of Michigan SPORE titled Molecularly Targeted Radiosensitization of Locally Advanced Cancers. The Core assists investigators with the proper planning of experiments and choice of technologies, assists with the information management of laboratory-based experimental and clinical data generated by SPORE projects, and conducts rigorous biostatistical and bioinformatics analyses in close collaboration with the SPORE investigators. The BCB Core includes members with diverse expertise and experience. The core leaders, Drs. Schipper and Rao, are assisted by faculty and staff analysts and programmers with the expertise needed to support the activities in the SPORE. The core will support data flow and warehousing within the SPORE as well as with entities outside of the SPORE. Both leaders are integrated into the biostatistical and bioinformatic infrastructures at the University of Michigan Rogel Cancer Center, and they can call on additional assistance as needed to support the evolving research of the SPORE. The Core has the flexibility to match personnel to the needs of existing and developmental SPORE projects.