Core A: Biostatistics and Computational Biology Core

核心A：生物统计学和计算生物学核心

• 批准号: 10554475
• 负责人: Matthew Schipper
• 金额: $ 30.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-14 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554475
• 关键词: Algorithms; Bioinformatics; Biometry; Cancer Center; Clinical Data; Clinical Trials Design; Collaborations; Computational Biology; Conduct Clinical Trials; Consult; Data; Data Analyses; Data Set; Development; Ensure; Faculty; Human Resources; Information Management; Laboratories; Locally Advanced Malignant Neoplasm; Michigan; Modeling; Modernization; Molecular Target; Radiosensitization; Research; Research Design; Research Personnel; Standardization; Statistical Data Interpretation; Technology; Universities; Work; analysis pipeline; bioinformatics infrastructure; data exchange; data integrity; data management; data sharing; experience; experimental study; flexibility; member; pre-clinical; programs; single-cell RNA sequencing

PROJECT SUMMARY/ABSTRACT (CORE A, BIOSTATISTICS AND COMPUTATIONAL BIOLOGY CORE) The Biostatistics and Computational Biology (BCB) Core provides comprehensive professional support to ensure statistical integrity, including study design, algorithm selection and implementation, data integrity across the entire research cycle, internal and external data sharing, and data analysis/interpretation of the studies performed by the University of Michigan SPORE titled Molecularly Targeted Radiosensitization of Locally Advanced Cancers. The Core assists investigators with the proper planning of experiments and choice of technologies, assists with the information management of laboratory-based experimental and clinical data generated by SPORE projects, and conducts rigorous biostatistical and bioinformatics analyses in close collaboration with the SPORE investigators. The BCB Core includes members with diverse expertise and experience. The core leaders, Drs. Schipper and Rao, are assisted by faculty and staff analysts and programmers with the expertise needed to support the activities in the SPORE. The core will support data flow and warehousing within the SPORE as well as with entities outside of the SPORE. Both leaders are integrated into the biostatistical and bioinformatic infrastructures at the University of Michigan Rogel Cancer Center, and they can call on additional assistance as needed to support the evolving research of the SPORE. The Core has the flexibility to match personnel to the needs of existing and developmental SPORE projects.

项目总结/摘要（核心A，生物统计学和预防生物学核心） 生物统计学和计算生物学（BCB）核心提供全面的专业支持，以确保 统计完整性，包括研究设计、算法选择和实施、数据完整性 整个研究周期，内部和外部数据共享，以及研究的数据分析/解释 由密歇根大学SPORE进行，标题为局部分子靶向放射增敏 晚期癌症核心帮助研究人员进行适当的实验计划和选择 技术，协助基于实验室的实验和临床数据的信息管理 由SPORE项目产生，并进行严格的生物统计学和生物信息学分析， 与SPORE调查人员合作。BCB核心包括具有不同专业知识的成员， 体验.核心领导人，Schipper和Rao博士，由教职员工分析师协助， 具有支持SPORE中的活动所需的专业知识的程序员。核心将支持数据流 和存储在SPORE内以及与SPORE外的实体。两位领导人都是一体化的 密歇根大学罗吉尔癌症中心的生物统计和生物信息学基础设施， 他们可以要求额外的援助，以支持不断发展的研究的孢子。核心 灵活地将人员与现有和发展中的SPORE项目的需求相匹配。