Core 2: Biostatistics and Bioinformatics Core (BBC)

核心2：生物统计学和生物信息学核心（BBC）

• 批准号: 10555404
• 负责人: Shuang Zhao
• 金额: $ 21.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555404
• 关键词: Archives; Area; Basic Science; Bioinformatics; Biometry; Biostatistics Shared Resource; Cancer Center; Clinical; Clinical Research; Clinical Sciences; Collaborations; Consultations; Data; Data Analyses; Data Collection; Dedications; Development; Doctor of Philosophy; Ensure; Experimental Designs; Formulation; Head Cancer; Human; Human Resources; Individual; Information Dissemination; Laboratories; Laboratory Study; Malignant neoplasm of prostate; Manuscripts; Medical Informatics; Methods; Neck Cancer; Office of Administrative Management; Oncology; Pathology; Physicians; Program Development; Prostate; Publications; Quality Control; Radiology Specialty; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Scientist; Secure; Senior Scientist; Standardization; Translations; Universities; Validation; Wisconsin; Writing; archive data; career; career development; data archive; data management; data sharing; data standards; design; experience; experimental study; multidisciplinary; neoplasm resource; professor; programs; quality assurance; research study; success; translational cancer research

PROJECT SUMMARY The objective of the Biostatistics and Bioinformatics Core (BBC) of the University of Wisconsin (UW) Prostate Cancer SPORE, is to promote excellence in prostate cancer translational and clinical research by providing dedicated and outstanding biostatistical and bioinformatic consultation and collaborative support to the Prostate Cancer SPORE projects, Radiopathology Core, Administrative Core, and other investigators whose projects are supported under the Developmental Research Program and Career Development Program. This support and collaboration will include laboratory and clinical-based research, focusing on translation from laboratory studies to clinical studies. The BBC will achieve its objective by supporting investigators and providing statistical, bioinformatics, and data management expertise, thus enhancing the quality and ensuring the validity of the research undertaken in the Prostate Cancer SPORE. The BBC will provide expertise in all stages of the research, from formulation of research questions through study experimental design, data collection and management, to data analysis, interpretation and dissemination of results through publications. The Specific Aims of the Core are: Specific Aim 1. To collaborate with the UW Prostate Cancer SPORE investigators in study design, analysis, and interpretation of data, and writing of scientific manuscripts. Specific Aim 2. To ensure the transparency and validity of statistical and bioinformatic analysis via rigorous data collection, standardization of the variety of data that arise from the UW Prostate Cancer SPORE projects, confidential and secure data archiving and data sharing, and centralized data management activities including validation and consistency checking of all collected data. Specific Aim 3. To develop new statistical and bioinformatics methods relevant to the individual projects.

项目摘要 威斯康星州大学前列腺生物统计学和生物信息学核心（BBC）的目标 癌症孢子，是促进卓越的前列腺癌转化和临床研究，提供 为前列腺提供专业和出色的生物统计学和生物信息学咨询和协作支持 癌症孢子项目，放射病理学核心，行政核心，和其他研究人员的项目是 在发展研究计划和职业发展计划的支持下。这种支助和 合作将包括实验室和临床研究，重点是从实验室研究翻译 临床研究。英国广播公司将通过支持调查人员和提供统计数据， 生物信息学和数据管理专业知识，从而提高质量和确保有效性， 前列腺癌的治疗方法有哪些英国广播公司将在研究的各个阶段提供专业知识， 从研究问题的制定到研究实验设计、数据收集和管理， 数据分析、解释和通过出版物传播结果。 核心的具体目标是： 具体目标1.与UW前列腺癌SPORE研究人员合作进行研究设计，分析， 数据的解释和科学手稿的写作。 具体目标2。为了确保统计和生物信息学分析的透明度和有效性， 数据收集，来自UW前列腺癌SPORE项目的各种数据的标准化， 保密和安全的数据存档和数据共享，以及集中的数据管理活动，包括 验证和一致性检查所有收集的数据。 具体目标3。开发与各个项目相关的新的统计和生物信息学方法。