Core 2: Biostatistics and Bioinformatics Core (BBC)

核心2：生物统计学和生物信息学核心（BBC）

• 批准号: 10555404
• 负责人: Shuang Zhao
• 金额: $ 21.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555404
• 关键词: Archives; Area; Basic Science; Bioinformatics; Biometry; Biostatistics Shared Resource; Cancer Center; Clinical; Clinical Research; Clinical Sciences; Collaborations; Consultations; Data; Data Analyses; Data Collection; Dedications; Development; Doctor of Philosophy; Ensure; Experimental Designs; Formulation; Head Cancer; Human; Human Resources; Individual; Information Dissemination; Laboratories; Laboratory Study; Malignant neoplasm of prostate; Manuscripts; Medical Informatics; Methods; Neck Cancer; Office of Administrative Management; Oncology; Pathology; Physicians; Program Development; Prostate; Publications; Quality Control; Radiology Specialty; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Scientist; Secure; Senior Scientist; Standardization; Translations; Universities; Validation; Wisconsin; Writing; archive data; career; career development; data archive; data management; data sharing; data standards; design; experience; experimental study; multidisciplinary; neoplasm resource; professor; programs; quality assurance; research study; success; translational cancer research

PROJECT SUMMARY The objective of the Biostatistics and Bioinformatics Core (BBC) of the University of Wisconsin (UW) Prostate Cancer SPORE, is to promote excellence in prostate cancer translational and clinical research by providing dedicated and outstanding biostatistical and bioinformatic consultation and collaborative support to the Prostate Cancer SPORE projects, Radiopathology Core, Administrative Core, and other investigators whose projects are supported under the Developmental Research Program and Career Development Program. This support and collaboration will include laboratory and clinical-based research, focusing on translation from laboratory studies to clinical studies. The BBC will achieve its objective by supporting investigators and providing statistical, bioinformatics, and data management expertise, thus enhancing the quality and ensuring the validity of the research undertaken in the Prostate Cancer SPORE. The BBC will provide expertise in all stages of the research, from formulation of research questions through study experimental design, data collection and management, to data analysis, interpretation and dissemination of results through publications. The Specific Aims of the Core are: Specific Aim 1. To collaborate with the UW Prostate Cancer SPORE investigators in study design, analysis, and interpretation of data, and writing of scientific manuscripts. Specific Aim 2. To ensure the transparency and validity of statistical and bioinformatic analysis via rigorous data collection, standardization of the variety of data that arise from the UW Prostate Cancer SPORE projects, confidential and secure data archiving and data sharing, and centralized data management activities including validation and consistency checking of all collected data. Specific Aim 3. To develop new statistical and bioinformatics methods relevant to the individual projects.

项目总结 威斯康星大学(UW)前列腺部生物统计和生物信息学核心(BBC)的目标 癌症孢子，是为了促进前列腺癌翻译和临床研究的卓越，通过提供 致力于为前列腺癌提供杰出的生物统计学和生物信息学咨询和协作支持 癌症孢子项目、放射病理学核心、行政核心和其他研究人员，他们的项目是 在发展研究计划和职业发展计划下得到支持。这项支持和 合作将包括基于实验室和临床的研究，重点是将实验室研究转化为 到临床研究。英国广播公司将通过支持调查人员和提供统计数据， 生物信息学和数据管理专门知识，从而提高质量和确保数据的有效性 在前列腺癌孢子中进行的研究。英国广播公司将在研究的所有阶段提供专业知识， 从研究问题的形成到研究实验设计、数据收集和管理，到 通过出版物对结果进行数据分析、解释和传播。 核心的具体目标是： 具体目标1.与华盛顿大学前列腺癌孢子研究人员合作进行研究设计、分析、 以及数据的解释和科学手稿的写作。 具体目标2.确保统计和生物信息学分析的透明度和有效性 数据收集，来自威斯康星州前列腺癌孢子项目的各种数据的标准化， 保密和安全的数据存档和数据共享，以及集中的数据管理活动，包括 对所有收集的数据进行验证和一致性检查。 具体目标3.制定与个别项目有关的新的统计和生物信息学方法。