Translational Epidemiology - Training for Research on Aging and Chronic disease

转化流行病学 - 老龄化和慢性病研究培训

• 批准号: 10641744
• 负责人: Peggy Mannen Cawthon
• 金额: $ 96.11万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641744
• 关键词: Aging; Chronic Disease; Epidemiology; Research Training

PROJECT SUMMARY/ABSTRACT Chronic diseases impose a crushing burden on older adults and present unique intellectual, methodological, and statistical challenges to scientists and policy makers. These challenges were highlighted by the disproportionate impact of the COVID-19 pandemic on older adults with chronic conditions. In this resubmission of our renewal application for the UCSF T32 Translational Epidemiology - Training for Research on Aging and Chronic Conditions (TE-TRAC) program, we build on our successful first funding cycle. TE-TRAC pre- and post-doctoral trainees focus on aging and chronic diseases affecting the health of older adults, including Alzheimer’s disease and related disorders, cancer, musculoskeletal, and cardiometabolic disorders. Our T32 program provides trainees with outstanding quantitative research skills and substantive expertise relevant to aging, emphasizing: 1) substantive understanding of the epidemiology of aging and the intersection of biological and social processes relevant to the health of aging populations; 2) rigorous, reproducible analytic methods for complex data, including causal inference and statistical methods; 3) data skills to identify, access, link, and use multi-level data resources, such as longitudinal survey-based cohorts, electronic health records or “omic” information; 4) training in translational research to deliver evidence relevant to policy, clinical, or behavioral interventions to improve health; and 5) mentorship tailored to ensure trainee success in research careers. For pre-doctoral trainees, formal classroom training is combined with applied research rotations and co-curricular activities to foster rapid development of research expertise and expose students to diverse perspectives and methods. Post-doctoral trainees build individualized research agendas and lay the groundwork for their future careers. TE-TRAC is housed in the Department of Epidemiology and Biostatistics and faculty mentors with deep expertise in clinical and population research are drawn from across UCSF and its affiliates. TE-TRAC leadership works closely with faculty mentors individually and via the Mentoring Collaborative to foster optimal mentoring skill development. In its first 5 years, TE-TRAC has successfully recruited excellent trainees who have made outstanding professional progress. To date, 7/17 (41%) trainees have been from racial/ethnic groups underrepresented in science. Consistent with the goals of the NRSA program, our alumni have secured desirable positions both inside (78%) and outside (22%) academia. TE- TRAC has been oversubscribed with strong candidates and strong mentors, requiring that we turn away highly qualified pre- and post-doctoral fellows who would benefit from participation and enrich the experience of other trainees. We therefore seek to increase from 2 to 3 second-year pre-doctoral and from 2 to 4 post-doctoral slots per incoming cohort. An External Advisory Committee will monitor and evaluate the program. The TE- TRAC program is training exceptional quantitative researchers prepared to leverage the rapidly expanding methodologic and data repertoires available to address urgent questions on the health of aging populations.

项目摘要/摘要 慢性病给老年人带来了沉重的负担，并呈现出独特的智力、方法和 以及对科学家和政策制定者的统计挑战。这些挑战被突显为 新冠肺炎疫情对患有慢性病的老年人的影响不成比例。在这 重新提交加州大学旧金山分校T32翻译流行病学-研究培训续签申请 关于老龄化和慢性病(TE-TRAC)计划，我们建立在我们成功的第一个资金周期的基础上。TE-TRAC 博士后和博士后培训的重点是影响老年人健康的老龄化和慢性病， 包括阿尔茨海默病及相关疾病、癌症、肌肉骨骼和心脏新陈代谢疾病。 我们的T32计划为学员提供出色的量化研究技能和实质性的专业知识 与老龄化有关，强调：1)对老龄化流行病学和交叉点有实质性的理解 与老龄人口健康相关的生物和社会过程；2)严谨、可重复的分析 复杂数据的方法，包括因果推理和统计方法；3)识别、获取、 链接和使用多层次数据资源，如基于纵向调查的队列、电子健康记录或 4)提供翻译研究方面的培训，以提供与政策、临床或 改善健康的行为干预；以及5)为确保学员在研究中取得成功而量身定做的导师制 事业。对于博士前学员，正规的课堂培训与应用研究轮换相结合 联合课程活动，以促进研究专业知识的快速发展，并使学生接触到不同的 视角和方法。博士后实习生建立个性化的研究议程，并为 为他们未来的职业生涯奠定基础。TE-TRAC设在流行病学和生物统计系 在临床和人口研究方面拥有深厚专业知识的教员导师来自加州大学旧金山分校和 它的附属公司。TE-TRAC领导层与教师导师个人和通过指导密切合作 协作以促进最佳指导技能的发展。在最初的5年里，TE-TRAC成功地 招收专业进步突出的优秀实习生。到目前为止，7/17(41%)学员 来自科学界代表性不足的种族/民族群体。与NRSA的目标一致 通过该项目，我们的校友在学术界(78%)和外部(22%)都获得了理想的职位。TE- TRAC已经被强大的候选人和强大的导师超额认购，这要求我们高度拒绝 合格的博士后和博士后研究员，他们将从参与中受益，并丰富其他 实习生。因此，我们寻求将博士后从2年前增加到3年，博士后从2年增加到4年。 每个传入队列的时隙。一个外部咨询委员会将监督和评估该计划。这个TE- TRAC计划正在培训杰出的量化研究人员，准备利用快速扩张的 可用于解决老龄人口健康的紧急问题的方法学和数据汇编。

项目成果

Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores.

• DOI: 10.1002/alz.12134
• 发表时间: 2020-10
• 期刊: Alzheimer's & dementia : the journal of the Alzheimer's Association
• 作者: Brenowitz WD;Kaup AR;Yaffe K
• 通讯作者: Yaffe K

Reply by Authors.

作者回复。

• DOI: 10.1097/ju.0000000000003038.02
• 发表时间: 2023
• 期刊: The Journal of urology
• 作者: Schweizer,MichaelT;True,Lawrence;Gulati,Roman;Zhao,Yibai;Ellis,William;Schade,George;Montgomery,Bruce;Goyal,Sonia;Nega,Katie;Hakansson,AlexanderK;Liu,Yang;Davicioni,Elai;Pienta,Kenneth;Nelson,PeterS;Lin,Daniel;Wright,Jona
• 通讯作者: Wright,Jona

Excess Mortality in California by Education During the COVID-19 Pandemic.

• DOI: 10.1016/j.amepre.2022.06.020
• 发表时间: 2022-11
• 期刊: AMERICAN JOURNAL OF PREVENTIVE MEDICINE
• 影响因子: 5.5
• 作者: Chen, Yea-Hung;Matthay, Ellicott C.;Chen, Ruijia;DeVost, Michelle A.;Duchowny, Kate A.;Riley, Alicia R.;Bibbins-Domingo, Kirsten;Glymour, M. Maria
• 通讯作者: Glymour, M. Maria

A human-machine partnered approach for identifying social media signals of elevated traumatic grief in Chicago gang territories.

一种人机合作方法，用于识别芝加哥帮派地区创伤性悲伤加剧的社交媒体信号。

• DOI: 10.1371/journal.pone.0236625
• 发表时间: 2020
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Stuart,Forrest;Riley,Alicia;Pourreza,Hossein
• 通讯作者: Pourreza,Hossein

Genetic ancestry and diagnostic yield of exome sequencing in a diverse population.

• DOI: 10.1038/s41525-023-00385-6
• 发表时间: 2024-01-03
• 期刊: NPJ GENOMIC MEDICINE
• 影响因子: 5.3
• 作者: Mavura, Yusuph;Sahin-Hodoglugil, Nuriye;Hodoglugil, Ugur;Kvale, Mark;Martin, Pierre-Marie;Van Ziffle, Jessica;Devine, W. Patrick;Ackerman, Sara L.;Koenig, Barbara A.;Kwok, Pui-Yan;Norton, Mary E.;Slavotinek, Anne;Risch, Neil
• 通讯作者: Risch, Neil