Project 3: Intraarticular Mineralization
项目3:关节内矿化
基本信息
- 批准号:10555688
- 负责人:
- 金额:$ 75.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2028-02-29
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAlgorithmsAnatomyAnti-Cytokine TherapyArthritisBloodC-reactive proteinCalciumCalcium PyrophosphateCalcium pyrophosphate deposition diseaseCartilageCollectionCrystal FormationDataDegenerative polyarthritisDevelopmentDiseaseFoundationsIL18 geneImageImage AnalysisIncidenceIndividualInflammationInflammatoryInterleukin-1 betaInterleukin-6JointsKneeKnee OsteoarthritisKnowledgeLocationMagnetic Resonance ImagingMeniscus structure of jointMethodsModificationOutcomePainPathologyPathway interactionsPatternPersonsPhenotypePhysicsPlacebosPrevalencePrevention strategyProteomicsPseudogoutQuestionnairesReplacement ArthroplastyResearchRoleSerumShoulderSpectroscopy, Fourier Transform InfraredSubgroupSymptomsSynovial FluidTestingTractionUrateWorkX-Ray Computed Tomographycalcificationcalcium phosphatecardiovascular risk factorclinically relevantcytokinedeep learningdifferential expressionexperienceinflammatory markerinnovationinsightknee painmineralizationnovelradiological imagingsoft tissuesystemic inflammatory responsetreatment strategytwo-dimensionalultrasound
项目摘要
ABSTRACT Project 3: Intra-Articular Mineralization
Intra-articular (IA) mineralization due to calcium crystal deposition is common in knee osteoarthritis (OA), and
may contribute to inflammation, structural pathology, and pain. However, prior studies have been conflicting
regarding its clinical relevance, likely partly due to reliance on relatively insensitive radiographs. In addition, the
particular crystal type may have different consequences in OA. We plan to address these key knowledge gaps
by use of dual energy CT (DECT) to more sensitively detect IA mineralization, and apply a novel image analysis
method to differentiate type of crystal present in the IA mineralization. We hypothesize that IA calcium crystal
deposition may induce low-grade inflammation that can contribute to pain and its fluctuation in OA. Further,
particular types of calcium crystal (calcium pyrophosphate [CPP] vs. basic calcium phosphate [BCP]) may
contribute differently to OA outcomes. Clarification of potential consequences of IA mineralization and specific
crystal types in knee OA would enable examination of IA mineralization as a treatment target in OA with therapies
such as anti-IL-1β or other anti-cytokine therapy addressing inflammation due to crystals. We will leverage data
collected in the Multicenter Osteoarthritis (MOST) Study, including previously acquired DECT and stored blood
biospecimens, and take advantage of the planned synovial fluid acquisition in conjunction with the proposed
MOST4 Project 4 on synovial fluid proteomics. Using these rich data, we propose to evaluate the following: 1)
the relation of IA mineralization to pain fluctuation over two years; 2) the relation of IA mineralization to serum
inflammatory markers; 3) type of crystal (CPP vs. BCP) and volume of each type using novel DECT image
analysis, and determine the extent to which each crystal type is related to serum inflammatory signatures,
structural progression, and pain; 4) To examine the synovial inflammatory signatures via proteomics in knees
with crystal-proven CPP vs. BCP (exploratory pilot aim). We will work with Dr. Fabio Becce who has developed
the novel image analysis methods to differentiate crystal type on DECT, as well as with Dr. Ann Rosenthal who
will use Fourier transform infrared spectroscopy to identify crystal type in synovial fluid to permit proteomics
analysis of synovial fluid containing CPP vs. BCP. In exploratory analysis using deep learning, we will evaluate
the relationship of crystal type to co-localized predicted cartilage loss. These proposed studies are innovative as
they will provide novel insights into the inter-relationships between IA crystals, inflammation, pain, and pathology
in OA. The proposed research is significant as such insights would lay the foundation for identifying an important
OA phenotype targetable by effective anti-cytokine therapy leading to disease modification. This would provide
an important breakthrough for this disease in which there are no disease-modifying therapies available to date.
项目3:关节内矿化
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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TUHINA NEOGI其他文献
TUHINA NEOGI的其他文献
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{{ truncateString('TUHINA NEOGI', 18)}}的其他基金
Project 1: Impaired Exercise Induced Hypoalgesia
项目 1:运动损伤引起的痛觉减退
- 批准号:
10555686 - 财政年份:2023
- 资助金额:
$ 75.52万 - 项目类别:
Boston University Rheumatology Research Training (BURRT) T32 Program
波士顿大学风湿病学研究培训 (BURRT) T32 计划
- 批准号:
10623340 - 财政年份:2022
- 资助金额:
$ 75.52万 - 项目类别:
Boston University Rheumatology Research Training (BURRT) T32 Program
波士顿大学风湿病学研究培训 (BURRT) T32 计划
- 批准号:
10409984 - 财政年份:2022
- 资助金额:
$ 75.52万 - 项目类别:
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and Pain
尿酸盐在膝骨关节炎相关炎症、病理和疼痛中的作用
- 批准号:
9223170 - 财政年份:2017
- 资助金额:
$ 75.52万 - 项目类别:
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and Pain
尿酸盐在膝骨关节炎相关炎症、病理和疼痛中的作用
- 批准号:
10199929 - 财政年份:2017
- 资助金额:
$ 75.52万 - 项目类别:
Central Sensitization in Post-Knee Replacement Pain and Relation to OA Pathology
膝关节置换术后疼痛的中枢敏化及其与 OA 病理学的关系
- 批准号:
8900960 - 财政年份:2012
- 资助金额:
$ 75.52万 - 项目类别:
Central Sensitization in Post-Knee Replacement Pain and Relation to OA Pathology
膝关节置换术后疼痛的中枢敏化及其与 OA 病理学的关系
- 批准号:
8544975 - 财政年份:2012
- 资助金额:
$ 75.52万 - 项目类别:
Central Sensitization in Post-Knee Replacement Pain and Relation to OA Pathology
膝关节置换术后疼痛的中枢敏化及其与 OA 病理学的关系
- 批准号:
8437321 - 财政年份:2012
- 资助金额:
$ 75.52万 - 项目类别:
Predictors and Consequences of Subchondral Bone Attrition in Osteoarthritis
骨关节炎软骨下骨磨损的预测因子和后果
- 批准号:
7924736 - 财政年份:2007
- 资助金额:
$ 75.52万 - 项目类别:
Predictors and Consequences of Subchondral Bone Attrition in Osteoarthritis
骨关节炎软骨下骨磨损的预测因子和后果
- 批准号:
7496498 - 财政年份:2007
- 资助金额:
$ 75.52万 - 项目类别:
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