Yersinia Outer-Membrane-Vesicle Vaccines Against Pneumonic Plague

鼠疫耶尔森氏菌外膜囊泡疫苗

基本信息

  • 批准号:
    10555332
  • 负责人:
  • 金额:
    $ 70.69万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-25 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

SUMMARY Yersinia pestis, the etiologic agent of plague, has been responsible for high mortality in several epidemics throughout human history. Plague has been classified as a re-emerging disease by the World Health Organization since there are several thousand reported cases of the disease worldwide annually and multidrug-resistant Y. pestis strains occur in recent years. The plague bacillus has been used as a biological weapon recorded in human history and is one of the more likely biological threats to be used by terrorists. Currently, no licensed plague vaccines are available in Western world. Isolation of virulent F1-negative Y. pestis strains from natural sources and the existence of lcrV polymorphisms in Yersinia may result in Y. pestis variants that escape protective immunity induced by LcrV and F1 antigens. Therefore, vaccines solely based upon LcrV and F1 antigens is insufficient to guarantee long-term defense against plague in humans. In order to overcome the drawbacks of subunit vaccines composed of LcrV and F1 antigens, we propose to use Y. pseudotuberculosis (Yptb) OMVs as an acellular vaccine against plague: (1) Construct Yptb strains which robustly produce highly immunogenic self-adjuvanting OMVs carrying an array of Y. pestis protective antigens; (2) Evaluate protective immunity of OMVs in rodents (mouse and rat). (3) Carefully decipher mechanisms of immune protection induced by the Yersinia OMVs to provide fundamentals for rational plague vaccine development. Finally, the success of this project will provide highly effective and safe plague vaccines for humans.
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项目成果

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Wei Sun其他文献

Wei Sun的其他文献

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{{ truncateString('Wei Sun', 18)}}的其他基金

Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit
用于早期癌症评估的液体活检的竞争前合作:数据管理和协调单位
  • 批准号:
    10838127
  • 财政年份:
    2023
  • 资助金额:
    $ 70.69万
  • 项目类别:
Post-GWAS Functional Genomics Analysis to Define Pathogenic Mechanisms for Pulmonary Arterial Hypertension
GWAS 后功能基因组学分析确定肺动脉高压的致病机制
  • 批准号:
    10524975
  • 财政年份:
    2022
  • 资助金额:
    $ 70.69万
  • 项目类别:
Yersinia Outer-Membrane-Vesicle Vaccines Against Pneumonic Plague
鼠疫耶尔森氏菌外膜囊泡疫苗
  • 批准号:
    10673295
  • 财政年份:
    2022
  • 资助金额:
    $ 70.69万
  • 项目类别:
Yersinia Outer-Membrane-Vesicle Vaccines Against Pneumonic Plague
鼠疫耶尔森氏菌外膜囊泡疫苗
  • 批准号:
    10441853
  • 财政年份:
    2022
  • 资助金额:
    $ 70.69万
  • 项目类别:
Post-GWAS Functional Genomics Analysis to Define Pathogenic Mechanisms for Pulmonary Arterial Hypertension
GWAS 后功能基因组学分析确定肺动脉高压的致病机制
  • 批准号:
    10697364
  • 财政年份:
    2022
  • 资助金额:
    $ 70.69万
  • 项目类别:
Statistical Methods for T Cell Receptor (TCR) Analysis
T 细胞受体 (TCR) 分析的统计方法
  • 批准号:
    10620574
  • 财政年份:
    2022
  • 资助金额:
    $ 70.69万
  • 项目类别:
Statistical Genetics and Genomics for Epidemiologic Research
流行病学研究的统计遗传学和基因组学
  • 批准号:
    10426287
  • 财政年份:
    2018
  • 资助金额:
    $ 70.69万
  • 项目类别:
A novel computing framework to automatically process cardiac valve image data and predict treatment outcomes
一种新颖的计算框架,可自动处理心脏瓣膜图像数据并预测治疗结果
  • 批准号:
    9973167
  • 财政年份:
    2018
  • 资助金额:
    $ 70.69万
  • 项目类别:
Yersinia pseudotuberculosis-based vaccines for plague and yersiniosis
基于假结核耶尔森氏菌的鼠疫和耶尔森氏菌疫苗
  • 批准号:
    9471106
  • 财政年份:
    2016
  • 资助金额:
    $ 70.69万
  • 项目类别:
Biomechanical study on aortic-mitral coupling in transcatheter aortic valve replacement
经导管主动脉瓣置换术中主动脉-二尖瓣耦合的生物力学研究
  • 批准号:
    9274379
  • 财政年份:
    2016
  • 资助金额:
    $ 70.69万
  • 项目类别:

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无细胞疫苗是否会导致缺乏百日咳博德特氏菌的增加
  • 批准号:
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