Multidisciplinary Approach Training in Respiratory Research

呼吸研究多学科方法培训

• 批准号: 10555619
• 负责人: Augustine M Choi
• 金额: $ 66.33万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555619
• 关键词: Research; Training; interdisciplinary approach; respiratory

Abstract The Multidisciplinary Research Training Program (MRTP) in pulmonary disease provides comprehensive research training for individuals committed to a career in lung biology and biomedical research. Our main objective is to provide structured, intensive research and didactic training to pulmonary physicians at the GME fellowship level and Ph.D. scientists with interests in lung disease. Our primary goal is to foster the development of trainee skills needed to pursue successful investigative careers. We recognize the importance of multidisciplinary training and the synergy of interactions among M.D., M.D./Ph.D., D.O. and Ph.D. trainees. We provide broad access to two training modules, basic or clinical science, bridging a translational continuum. For those pursuing a predominantly basic science pathway, the key training activity will be mentored time in a basic research laboratory, supplemented by participation at research conferences and targeted didactic education. For those choosing a more clinical focus, the key training activity will be mentored time conducting a clinically focused research project coupled with didactic training focused on gaining clinical study design skills, while ensuring translational expertise. We appreciate that this basic-translational-clinical continuum is fluid as we focus on providing participants opportunities to explore the translational relevance of their investigative focus. Drs. Fernando Martinez and Augustine Choi serve as co-Program Directors, while Drs. Robert Kaner and Heather Stout-Delgado serve as Associate Program Directors. This group has a long record of investigative and mentoring collaboration, while refining a robust approach to comprehensive assessment of trainee progress with a series of overlapping systems that allow a careful tracking of trainees achieving pre-established benchmarks and timetables. The program leverages a dynamic mentoring team with robust training units comprised of an outstanding multidisciplinary faculty with active research programs in either lung disease or in disciplines relevant to lung disease. Our recipe for success remains a simple and focused one: a) identify three post-doctoral trainees yearly with a demonstrated interest in a research focused career; b) structure a nurturing and productive environment; c) identify a mentor and/or co-mentor ideally suited to provide training and mentoring; and d) provide a period of support (up to 3 years) so that training can progress to a point where the emerging investigator can compete for an entry level award and thrive as an independent investigator.

摘要 肺部疾病的多学科研究培训计划(MRTP)提供了全面的 为致力于肺部生物学和生物医学研究的个人提供研究培训。我们的Main 目标是为GME的肺科医生提供有组织的、密集的研究和教学培训 研究员级别和对肺部疾病感兴趣的博士科学家。我们的首要目标是促进 获得成功的调查职业所需的实习生技能。我们认识到 多学科培训以及医学博士、医学博士/博士、医学博士和博士学员之间互动的协同作用。我们 提供两个培训模块的广泛访问，基础或临床科学，架起翻译连续体的桥梁。为 那些追求以基础科学为主的途径的人，关键的培训活动将在基础时间内得到指导 研究实验室，辅以参加研究会议和有针对性的教学教育。为 那些选择更多临床重点的人，关键的培训活动将是指导时间进行临床重点 研究项目与教学培训相结合，侧重于获得临床研究设计技能，同时确保 翻译专业知识。我们理解这种基础-翻译-临床连续性是流动的，因为我们专注于 为参与者提供探索其调查重点的翻译相关性的机会。戴维斯博士。 费尔南多·马丁内斯和奥古斯丁·崔担任联合项目主任，罗伯特·卡纳博士和希瑟博士担任 Stout-Delgado担任副项目主任。该组织有长期的调查和调查记录 指导协作，同时完善全面评估实习生进展的可靠方法 一系列相互重叠的系统，允许仔细跟踪达到预先建立的基准的受训者 还有时间表。该计划利用一个动态的指导团队，拥有强大的培训单位，由 优秀的多学科教师，在肺部疾病或相关学科有积极的研究计划 与肺病有关。我们的成功秘诀仍然是简单而专注的：a)确定三名博士后实习生 每年一次，对专注于研究的职业表现出兴趣；b)构建一个有教养和生产力的 环境；c)确定最适合提供培训和指导的导师和/或共同导师；和d) 提供一段时间的支持(最长3年)，以便培训可以发展到新出现的调查员 可以竞争入门级奖项，并作为一名独立调查员茁壮成长。

项目成果

Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies.

• DOI: 10.3389/fimmu.2021.781100
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Suhre K;Sarwath H;Engelke R;Sohail MU;Cho SJ;Whalen W;Alvarez-Mulett S;Krumsiek J;Choi AMK;Schmidt F
• 通讯作者: Schmidt F

Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome.

• DOI: 10.1016/j.ajpath.2022.04.002
• 发表时间: 2022-07
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Price, David R.;Benedetti, Elisa;Hoffman, Katherine L.;Gomez-Escobar, Luis;Alvarez-Mulett, Sergio;Capili, Allyson;Sarwath, Hina;Parkhurst, Christopher N.;Lafond, Elyse;Weidman, Karissa;Ravishankar, Arjun;Cheong, Jin Gyu;Batra, Richa;Buyukozkan, Mustafa;Chetnik, Kelsey;Easthausen, Imaani;Schenck, Edward J.;Racanelli, Alexandra C.;Reed, Hasina Outtz;Laurence, Jeffrey;Josefowicz, Steven Z.;Lief, Lindsay;Choi, Mary E.;Schmidt, Frank;Borczuk, Alain C.;Choi, Augustine M. K.;Krumsiek, Jan;Rafii, Shahin
• 通讯作者: Rafii, Shahin

Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis.

• DOI: 10.1136/thoraxjnl-2021-217315
• 发表时间: 2022-03
• 期刊: Thorax
• 影响因子: 10
• 作者: Whalen W;Buyukozkan M;Moore B;Moon JS;Dela Cruz CS;Martinez FJ;Choi AMK;Krumsiek J;Stout-Delgado H;Cho SJ
• 通讯作者: Cho SJ

Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation.

• DOI: 10.1038/s41586-022-05380-y
• 发表时间: 2022-11
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Arifuzzaman, Mohammad;Won, Tae Hyung;Li, Ting-Ting;Yano, Hiroshi;Digumarthi, Sreehaas;Heras, Andrea F.;Zhang, Wen;Parkhurst, Christopher N.;Kashyap, Sanchita;Jin, Wen-Bing;Putzel, Gregory Garbes;Tsou, Amy M.;Chu, Coco;Wei, Qianru;Grier, Alex;Worgall, Stefan;Guo, Chun-Jun;Schroeder, Frank C.;Artis, David
• 通讯作者: Artis, David

Association of body mass index with morbidity in patients hospitalised with COVID-19.

• DOI: 10.1136/bmjresp-2021-000970
• 发表时间: 2021-08
• 期刊: BMJ open respiratory research
• 影响因子: 4.1
• 作者: Plataki M;Pan D;Goyal P;Hoffman K;Choi JMK;Huang H;Safford MM;Schenck EJ
• 通讯作者: Schenck EJ