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中文摘要
翻译
项目主任/首席调查员(华盛顿州托马斯·贝尔): 项目摘要 人体组织器官研究资源(HTORR)是国家疾病研究的一个分支 Interchange(NDRI),一个由NIH资助的非营利性组织,其使命是提供生物医学 与人体组织一起进行研究的研究社区。对人类生物标本的需求继续 与研究人员所希望的科学问题和实验方法的复杂性同步发展 去追寻。为了满足这一要求,HTORR利用了特定于项目的方法和多样化的组织网络 来源站点(TS)为调查人员提供了获得广泛的正常和疾病信息的机会 为他们的研究提供人类生物标本。HTORR的专业知识包括五个方面,以创建 可靠的研究资源,以满足这一紧急需要的调查人员。HTORR提供:1)专家客户 为调查人员提供全天候服务和支持,2)通过机会为调查人员提供面向解决方案的方法 为每个项目制定特定于项目的协议,3)获取不同范围的人类生物标本 所有机构系统,4)正在通过多个平台进行外联工作,以提高对资源的认识;以及 5)关于捐赠人体组织用于研究的行业最佳做法和标准。实施 该计划的实施将确保为高质量、有良好注解的正常人和患病人员提供不间断的服务 来自已建立的组织来源站点网络的研究人员,与 为生物医学研究社区制定和实施创新的大规模倡议。 OMB编号0925-0001/0002(批准的第03/2020版至2023年2月28日)续页格式页
英文摘要
Program Director/Principal Investigator (Bell, Thomas, J): Project Summary The Human Tissue and Organ Research Resource (HTORR) is a division of the National Disease Research Interchange (NDRI), a not-for-profit NIH-funded organization whose mission is to provide the biomedical research community with human tissues for research. The requirements for human biospecimens continue to evolve in tandem with complexity of scientific questions and experimental methodologies that investigators desire to pursue. To meet this requirement, HTORR utilizes a project-specific approach and a diverse network of tissue source sites (TSS) to provide investigators with the opportunity to obtain a broad range of normal and diseased human biospecimens for their studies. HTORR’s expertise involves a five-pronged approach to creating a reliable research resource to meet this emergent need for investigators. HTORR provides: 1) expert customer service and 24/7 support for investigators, 2) a solution-oriented approach for investigators via the opportunity to develop project-specific protocols for each project, 3) access to diverse range of human biospecimens from all body systems, 4) ongoing outreach efforts via multiple platforms to increase awareness of the resource, and 5) industry best practices and standards regarding the donation of human tissue for research. Implementation of this plan will ensure uninterrupted service of high quality, well annotated normal and diseased human biospecimens to investigators from an established network of tissue source sites, in concert with the development and implementation of innovative, large scale initiatives for the biomedical research community. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page
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DOI: 10.1016/j.celrep.2018.02.003
发表时间: 2018-02-20
期刊: Cell reports
影响因子: 8.8
作者: [Sathyamurthy A, Johnson KR, Matson KJE, Dobrott CI, Li L, Ryba AR, Bergman TB, Kelly MC, Kelley MW, Levine AJ]
通讯作者: Levine AJ
DOI: 10.1016/j.ijpharm.2022.121693
发表时间: 2022-04-25
期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS
影响因子: 5.8
作者: [Vora, Deepal, Garimella, Harsha T., German, Carrie L., Banga, Ajay K.]
通讯作者: Banga, Ajay K.
DOI: 10.1038/s41467-018-04049-3
发表时间: 2018-04-24
期刊: Nature communications
影响因子: 16.6
作者: [Dhandapani R, Arokiaraj CM, Taberner FJ, Pacifico P, Raja S, Nocchi L, Portulano C, Franciosa F, Maffei M, Hussain AF, de Castro Reis F, Reymond L, Perlas E, Garcovich S, Barth S, Johnsson K, Lechner SG, Heppenstall PA]
通讯作者: Heppenstall PA
DOI: 10.1167/iovs.18-24239
发表时间: 2018-07-02
期刊: Investigative ophthalmology & visual science
影响因子: 4.4
作者: [Guo X, Sriram S, Tran JA, Hutcheon AEK, Zieske JD]
通讯作者: Zieske JD
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    Tissue Procurement Center (TPC) Supporting the Somatic Mosaicism across Human Tissues (SMaHT) Network
    HTORR High Priority Alzheimer's Disease and Related Dementias Human Biospecimen Resource
    Research Resource for Human Organs and Tissues (U42)
    Research Resource for Human Organs and Tissues (U42)
    海外基金