Regulation of Cellular Behavior in Response to Extracellular Cues

响应细胞外信号的细胞行为调节

• 批准号: 10557022
• 负责人: Clarissa A Henry
• 金额: $ 246.11万
• 依托单位: UNIVERSITY OF MAINE ORONO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-05 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557022
• 关键词: APLN gene; Acceleration; Autophagocytosis; Biological; Biomedical Engineering; Biomedical Research; Cell Signaling Process; Cells; Centers of Research Excellence; Communicable Diseases; Complement; Core Facility; Cues; Cultured Cells; Development; Disease; Doctor' s Degree; Engineering; Environment; Facility Designs; Faculty; Funding; Future; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; Goals; Grant; Homeostasis; Image; Image Analysis; Industry; Influenza; Institution; Investments; Island; Laboratories; Leadership; Lytic; Maine; Medical center; Mentors; Mentorship; Microscopy; Modeling; Muscle; Muscle Cells; Myopathy; Natural regeneration; Neuromuscular Diseases; New England; Positioning Attribute; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Running; Science; Senior Scientist; Signal Transduction; Students; The Jackson Laboratory; Training; United States National Institutes of Health; Universities; Virus; Virus Diseases; Yeasts; Zebrafish; career; cell behavior; cell growth regulation; cell motility; cell type; experience; extracellular; graduate school; graduate student; imaging facilities; infectious disease treatment; innate immune function; meetings; migration; muscle aging; muscle regeneration; programs; recruit; response; success; teaching laboratory; virus infection mechanism

OVERALL ABSTRACT The long-term goal of this Center for Biomedical Research Excellence (COBRE) is to help grow the burgeoning biomedical research industry in Maine by positioning the University of Maine (UMaine) as a biomedical research and training hub that supports and recruits outstanding junior faculty while strengthening our unique statewide graduate program. This COBRE is focused on Regulation of Cellular Behavior in Response to Extracellular Cues. All cells interpret and respond to their environment, yet the mechanisms by which cells process signaling inputs and parse them into discrete cell behaviors are not fully understood. How does G protein coupled receptor signaling regulate polarity in different cell types? How does the extracellular environment regulate muscle cell behaviors such as migration and regeneration? How do viruses modify cells to cause disease? Five research projects led by early career investigators from UMaine and Mount Desert Island Biological Laboratory (MDIBL) will address cell-microenvironmental signaling across three contexts : mechanisms of viral infection in cultured cells and zebrafish; gradient tracking in yeast, and mechanisms of muscle homeostasis in zebrafish. The five research projects are: Cellular reprogramming in Persistent versus Lytic JC Viral Infections (Maginnis); Motility and Guidance Signals Control Migration of Muscle Precursors (Talbot); Mechanisms of GPCR-induced Autophagy (Kelley); Apelin Signaling in Muscle Regeneration (Madeleine), and Innate Immune Function in Influenza-Associated Myopathy (King). Each project leverages the unique expertise of research project leaders while advancing the theme of extracellular impacts on cell behavior. Projects exploit existing IDeA resources and the proposed new core facility in Microscopy and Image Analysis. This COBRE further enhances partnerships among biomedical research institutions in Maine. As director of a state-wide graduate program with 54 graduate students and >150 faculty, Dr. Henry has the leadership experience to guide this COBRE. This COBRE will accelerate the careers of our Junior Investigators by adding: external senior scientists as mentors, state-of-the art live imaging, image analytics, and an expanded zebrafish facility to strengthen the biomedical research infrastructure. UMaine is the only institution in the state that grants doctoral degrees in biomedical science and biomedical engineering. This COBRE, which will be UMaine’s first, will transform UMaine’s ability to serve as the academic leader for biomedical research in Maine and feed the growing biomedical research industry in Maine. This research will elucidate basic biological mechanisms underlying cell behavior, and also has the potential to inform future treatment of infectious diseases, neuromuscular disorders, and muscle aging and regeneration.

总体摘要 生物医学研究卓越中心（COBRE）的长期目标是帮助发展 新兴的生物医学研究产业在缅因州通过定位缅因州大学（U缅因州）作为一个 生物医学研究和培训中心，支持和招聘优秀的初级教师，同时加强 我们独特的全州研究生课程这个COBRE专注于细胞行为的调节， 对细胞外线索的反应。所有的细胞都对环境做出解释和反应，但它们的机制是， 哪些细胞处理信号输入并将它们解析成离散的细胞行为还没有完全理解。如何 G蛋白偶联受体信号调节不同细胞类型的极性吗？细胞外的 环境调节肌肉细胞的行为，如迁移和再生？病毒如何修饰细胞 导致疾病吗五个研究项目由来自UMaine和Mount Desert的早期职业调查人员领导 岛屿生物实验室（MDIBL）将在三种情况下解决细胞微环境信号： 培养细胞和斑马鱼中病毒感染的机制;酵母中的梯度跟踪，以及 斑马鱼的肌肉稳态这五个研究项目是：持续性细胞重编程与 裂解性JC病毒感染（Maginnis）;运动和指导信号控制肌肉前体的迁移 （塔尔博特）; GPCR诱导的自噬机制（Kelley）;肌肉再生中的Apelin信号转导 （Madeleine）和流感相关肌病中的先天免疫功能（King）。 每个项目都利用研究项目负责人的独特专业知识，同时推进以下主题： 细胞外对细胞行为的影响项目利用现有的IDEA资源和拟议的新核心 在显微镜和图像分析设施。该COBRE进一步加强了生物医学领域的伙伴关系， 缅因州的研究机构作为一个全州范围内的研究生项目的主任， >150名教员，亨利博士有领导经验，以指导这个眼镜蛇。这个眼镜蛇将加速 我们的初级研究员的职业生涯增加：外部高级科学家作为导师，最先进的生活 成像，图像分析，以及扩大斑马鱼设施，以加强生物医学研究 基础设施演进 缅因大学是该州唯一一所赠款生物医学博士学位的机构， 生物医学工程这将是UMaine的第一个COBRE，将改变UMaine作为 缅因州生物医学研究的学术领导者，并在 缅因州。这项研究将阐明细胞行为的基本生物学机制， 为未来治疗传染病、神经肌肉疾病和肌肉老化提供信息的潜力， 再生