Regulation of Cellular Behavior in Response to Extracellular Cues

总体摘要 该生物医学研究卓越中心(COBRE)的长期目标是帮助 缅因州新兴的生物医学研究行业通过将缅因州大学(UMaine)定位为 生物医学研究和培训中心，支持和招聘优秀的初级教师，同时加强 我们独特的全州研究生项目。这个科布雷专注于细胞行为的调节 对细胞外暗示的反应。所有的细胞都对环境做出解释和反应，然而这些机制通过 哪些细胞处理信号输入，并将它们解析为离散的细胞行为，目前还不完全清楚。多么 G蛋白偶联受体信号是否调节不同细胞类型的极性？细胞外是如何 环境调节肌肉细胞的迁移和再生等行为？病毒是如何修改细胞的 致病吗？由来自UMaine和Mountain Desert的早期职业调查人员领导的五个研究项目 岛屿生物实验室(MDIBL)将在三种情况下研究细胞微环境信号： 培养细胞和斑马鱼中病毒感染的机制；酵母中的梯度跟踪，以及 斑马鱼的肌肉动态平衡。这五个研究项目是：持久的细胞重新编程与 裂解性JC病毒感染(马金尼斯)；运动和引导信号控制肌肉前体的迁移 (Talbot)；GPCR诱导自噬的机制(Kelley)；肌肉再生中的Apelin信号 (Madeleine)和流感相关肌病的先天免疫功能(King)。 每个项目都利用了研究项目负责人的独特专业知识，同时推进了 细胞外对细胞行为的影响。项目利用现有的创意资源和提议的新核心 熟练掌握显微镜和图像分析技术。Cobre进一步加强了生物医学领域的合作伙伴关系 缅因州的研究机构。作为一个全州研究生项目的主任，有54名研究生和 &gt；150名教职员工，Henry博士拥有领导经验来指导这个Cobre。这只科布雷将加速 我们初级调查人员的职业生涯补充道：外部资深科学家作为导师，最先进的现场直播 成像、图像分析和扩展斑马鱼设施，以加强生物医学研究 基础设施。 UMaine是该州唯一一所授予生物医学博士学位和 生物医学工程学。这将是UMaine的第一个Cobre，将改变UMaine担任 缅因州生物医学研究的学术领先者，并推动了不断增长的生物医学研究行业 缅因州。这项研究将阐明细胞行为的基本生物学机制，并具有 有可能为未来传染病、神经肌肉疾病和肌肉老化的治疗提供信息 再生。

OVERALL ABSTRACT The long-term goal of this Center for Biomedical Research Excellence (COBRE) is to help grow the burgeoning biomedical research industry in Maine by positioning the University of Maine (UMaine) as a biomedical research and training hub that supports and recruits outstanding junior faculty while strengthening our unique statewide graduate program. This COBRE is focused on Regulation of Cellular Behavior in Response to Extracellular Cues. All cells interpret and respond to their environment, yet the mechanisms by which cells process signaling inputs and parse them into discrete cell behaviors are not fully understood. How does G protein coupled receptor signaling regulate polarity in different cell types? How does the extracellular environment regulate muscle cell behaviors such as migration and regeneration? How do viruses modify cells to cause disease? Five research projects led by early career investigators from UMaine and Mount Desert Island Biological Laboratory (MDIBL) will address cell-microenvironmental signaling across three contexts : mechanisms of viral infection in cultured cells and zebrafish; gradient tracking in yeast, and mechanisms of muscle homeostasis in zebrafish. The five research projects are: Cellular reprogramming in Persistent versus Lytic JC Viral Infections (Maginnis); Motility and Guidance Signals Control Migration of Muscle Precursors (Talbot); Mechanisms of GPCR-induced Autophagy (Kelley); Apelin Signaling in Muscle Regeneration (Madeleine), and Innate Immune Function in Influenza-Associated Myopathy (King). Each project leverages the unique expertise of research project leaders while advancing the theme of extracellular impacts on cell behavior. Projects exploit existing IDeA resources and the proposed new core facility in Microscopy and Image Analysis. This COBRE further enhances partnerships among biomedical research institutions in Maine. As director of a state-wide graduate program with 54 graduate students and >150 faculty, Dr. Henry has the leadership experience to guide this COBRE. This COBRE will accelerate the careers of our Junior Investigators by adding: external senior scientists as mentors, state-of-the art live imaging, image analytics, and an expanded zebrafish facility to strengthen the biomedical research infrastructure. UMaine is the only institution in the state that grants doctoral degrees in biomedical science and biomedical engineering. This COBRE, which will be UMaine’s first, will transform UMaine’s ability to serve as the academic leader for biomedical research in Maine and feed the growing biomedical research industry in Maine. This research will elucidate basic biological mechanisms underlying cell behavior, and also has the potential to inform future treatment of infectious diseases, neuromuscular disorders, and muscle aging and regeneration.