Understanding glycopolymer interactions with the extracellular matrix

了解糖聚合物与细胞外基质的相互作用

• 批准号: LP190101003
• 负责人: Prof Megan Lord
• 金额: $ 42.6万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-11-02 至 2023-11-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP190101003
• 关键词: Understanding; glycopolymer; interactions; extracellular; matrix

This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledge and ideas as well as advanced research and industrial training for young scientists. Knowledge derived from this project is expected to enable future innovation in molecules with tailored interactions with the glycocalyx with significant benefits for researchers, manufacturers and end users.

该项目旨在促进对内皮糖萼的生物化学和生物物理结构的了解，内皮糖萼是一种富含蛋白聚糖和糖胺聚糖的动态细胞表面细胞外基质。这将是第一个探索带电的糖聚合物如何与这个动态界面相互作用的目标是开发一个糖萼生命周期的模型。预计该项目将促进技能、知识和思想的转让，并为青年科学家提供先进的研究和工业培训。从该项目中获得的知识预计将使未来的分子创新与糖萼的定制相互作用，为研究人员，制造商和最终用户带来显着的好处。