Mental illness stigma as a risk factor for substance use among adults with depression

精神疾病耻辱是成年抑郁症患者滥用药物的危险因素

• 批准号: 10557223
• 负责人: Peng Wang
• 金额: $ 17.69万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10557223
• 关键词: Address; Adult; Alcohols; Area; Behavior; California; Cardiovascular system; Characteristics; Chronic; Cities; Clinical; Clinical Psychology; Cognitive; Complement; Consultations; Data Analyses; Dependence; Depressed mood; Diagnosis; Distress; Educational workshop; Emotional; Emotions; Ethics; Exposure to; Functional disorder; Funding; Future; Goals; Health; Health Resources; Heart Rate; Hydrocortisone; Individual; Instruction; Knowledge; Laboratories; Lead; Link; Longitudinal Studies; Major Depressive Disorder; Measurement; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Mentored Research Scientist Development Award; Mentors; Mentorship; Methodology; Methods; Modeling; Monitor; National Institute of Drug Abuse; Neurosecretory Systems; New York; Participant; Patient Self-Report; Persons; Physiological; Population; Populations at Risk; Positioning Attribute; Preparation; Principal Investigator; Productivity; Psychiatric Diagnosis; Psychologist; Public Health; Recovery; Regulation; Research; Research Design; Research Personnel; Research Priority; Research Project Grants; Research Scientist Award; Resources; Risk; Risk Factors; Role; Safety; Salivary; Sampling; San Francisco; Scientist; Self-control as a personality trait; Severities; Social Psychology; Stress; Substance abuse problem; Symptoms; Testing; Training; Trier Social Stress Test; United States National Institutes of Health; Universities; Work; barrier to care; career; college; comorbidity; coping; design; diaries; emotion regulation; emotional experience; emotional functioning; empowerment; experience; heart rate variability; hypothalamic-pituitary-adrenal axis; indexing; innovation; multimodality; negative affect; prevent; preventive intervention; psychiatric symptom; psychosocial stressors; recreational drug use; response; skill acquisition; skills; social; social stigma; stressor; substance abuse prevention; substance use; therapy design; tool

PROJECT SUMMARY/ABSTRACT The comorbidity between major depressive disorder, one of the most prevalent psychiatric conditions, and substance use represents a significant public health concern and a research priority for NIDA.1-7 Nevertheless, the role of mental illness stigma (i.e., social devaluation and rejection associated with one's psychiatric diagnosis) as a risk factor for substance use among individuals with depression remains under-examined. In addition to hindering treatment seeking and recovery,8-14 contending with stigma-related stress depletes self- regulatory resources and can thus lead to emotion dysfunction (i.e., intense, prolonged negative affect and maladaptive emotion regulation), a key mechanism underlying both depression and substance use problems.15‐ 29 The proposed research utilizes a multimethod approach to explicate the roles of mental illness stigma and co-occurring emotion dysfunction as risk factors for substance use among people with depression, with the goal of informing future efforts to develop targeted substance abuse prevention interventions for this at-risk population. Using 150 adults diagnosed with major depressive disorder with past 30-day substance use, the project will involve: (1) a lab study characterizing the impact of chronic stigma exposure on both physiological and self-report measures of emotion dysfunction in response to a stigma-related emotion induction (i.e., Trier Social Stress Test); and (2) a micro-longitudinal study documenting the concurrent and lagged associations among daily stigma experiences, emotion dysfunction, and alcohol and recreational drug use. The training acquired by the principal investigator, Dr. Peng “Katie” Wang, through the execution of this interdisciplinary, innovative research project, along with formal coursework, focused workshops, and one-on-one mentorship, will target the following three training objectives: (1) obtain instruction in the physiological assessment of emotional reactivity and regulation, including both cardiovascular and neuroendocrine measures; (2) develop expertise in micro-longitudinal research design, methodology, and data analysis; and (3) acquire skills in conducting research effectively with clinical populations while attending to relevant ethical and safety issues. Dr. Wang will be mentored primarily by Dr. John Pachankis at Yale University, with additional mentoring from Drs. Rajita Sinha (Yale University), Wendy Mendes (University of California, San Francisco), and Bruce Link (University of California, Riverside). Additionally, she will receive methodological and analytical consultation from Drs. Mark Hatzenbuehler (Columbia University) and Jonathon Rendina (Hunter College, City University of New York). Dr. Wang's proposed training through this K01 award will round out her expertise as a social-health psychologist by providing her with the knowledge and skills needed to launch a productive career as an independent research scientist in the field of substance abuse prevention.

项目总结/摘要 抑郁症是最常见的精神疾病之一， 药物使用是一个重大公共卫生问题，也是国家药物滥用局的一个研究重点。 精神疾病污名的作用（即，与精神病相关的社会贬低和排斥 诊断）作为抑郁症患者使用药物的风险因素仍然没有得到充分的研究。在 除了阻碍寻求治疗和康复外，8-14岁的人与与耻辱相关的压力作斗争， 调节资源并因此可导致情绪功能障碍（即，强烈、长期的负面影响， 适应不良的情绪调节），这是抑郁症和物质使用问题的关键机制。 29.拟议的研究利用多种方法来阐明精神疾病耻辱感的作用， 同时发生的情绪功能障碍是抑郁症患者使用药物的危险因素， 目标是为今后的努力提供信息，为这一高危群体制定有针对性的药物滥用预防干预措施 人口使用150名被诊断为重度抑郁症并在过去30天内使用药物的成年人， 项目将包括：（1）一项实验室研究，描述慢性耻辱暴露对生理和心理的影响。 以及响应于污名相关情绪诱导的情绪功能障碍的自我报告测量（即，特里尔 社会压力测试）;（2）一项微观纵向研究，记录了同时和滞后的关联 日常污名经历、情感障碍、酒精和娱乐性药物使用。培训 由首席研究员Peng“Katie”Wang博士通过执行这一跨学科， 创新研究项目，沿着正式课程，重点研讨会，和一对一的指导， 将针对以下三个培训目标：（1）获得生理评估的指导， 情绪反应和调节，包括心血管和神经内分泌措施;（2）发展 在微观纵向研究设计，方法和数据分析的专业知识;（3）获得技能， 在关注相关伦理和安全问题的同时，对临床人群进行有效的研究。 博士Wang将主要由耶鲁大学的John Pachankis博士指导， Drs. Rajita Sinha（耶鲁大学），Wendy门德斯（加州大学弗朗西斯科分校）和布鲁斯Link （加州大学，滨江）。此外，她将接受方法和分析咨询 来自Mark Hatzenbuehler博士（哥伦比亚大学）和JonedeRendina博士（亨特学院，城市大学）， 纽约）。王博士通过K 01奖提出的培训将完善她作为社会健康专家的专业知识， 心理学家通过为她提供所需的知识和技能，以启动一个富有成效的职业生涯， 药物滥用预防领域的独立研究科学家。

项目成果

The Role of Self-Conscious Emotions in the Sexual Health of Gay and Bisexual Men: Psychometric Properties and Theoretical Validation of the Sexual Shame and Pride Scale.

自我意识情绪在男同性恋和双性恋性健康中的作用： 性羞耻感和自豪感量表的心理测量学特性和理论验证》。

• DOI: 10.1080/00224499.2018.1453042
• 发表时间: 2019-05
• 期刊: Journal of sex research
• 影响因子: 3.6
• 作者: Rendina HJ;López-Matos J;Wang K;Pachankis JE;Parsons JT
• 通讯作者: Parsons JT

Evaluation and Durability of a Curriculum-Based Intervention for Promoting Mental Health among Graduate Students.

• DOI: 10.1080/19325037.2020.1822240
• 发表时间: 2020
• 期刊: American journal of health education
• 影响因子: 1
• 作者: Brett C;Wang K;Lowe SR;White MA
• 通讯作者: White MA

Barriers to mental health service use among people with disabilities during the COVID-19 pandemic.

COVID-19 大流行期间残疾人使用心理健康服务的障碍。

• DOI: 10.1037/rep0000512
• 发表时间: 2023
• 期刊: Rehabilitation psychology
• 影响因子: 2.7
• 作者: Manning,RobertB;Cipollina,Rebecca;Lowe,SarahR;Bogart,KathleenR;Ostrove,JoanM;Adler,JonathanM;Nario-Redmond,MichelleR;Wang,Katie
• 通讯作者: Wang,Katie

Narrative identity among people with disabilities in the United States during the Covid-19 pandemic: The interdependent self.

• DOI: 10.1016/j.jrp.2022.104302
• 发表时间: 2022-12
• 期刊: JOURNAL OF RESEARCH IN PERSONALITY
• 影响因子: 3.3
• 作者: Adler, Jonathan M.;Manning, Robert B., III;Hennein, Rachel;Winschel, Julia;Baldari, Alessandra;Bogart, Kathleen R.;Nario-Redmond, Michelle R.;Ostrove, Joan M.;Lowe, Sarah R.;Wang, Katie
• 通讯作者: Wang, Katie

A transdiagnostic minority stress intervention for gender diverse sexual minority women's depression, anxiety, and unhealthy alcohol use: A randomized controlled trial.

• DOI: 10.1037/ccp0000508
• 发表时间: 2020-07
• 期刊: Journal of consulting and clinical psychology
• 影响因子: 5.9
• 作者: Pachankis JE;McConocha EM;Clark KA;Wang K;Behari K;Fetzner BK;Brisbin CD;Scheer JR;Lehavot K
• 通讯作者: Lehavot K