Autonomic and Vascular Mechanisms of Cardiovascular Risk in Women with Post-traumatic Stress Disorder (PTSD)

患有创伤后应激障碍 (PTSD) 的女性心血管风险的自主神经和血管机制

• 批准号: 10596476
• 负责人: Ida Tchuisseu Fonkoue
• 金额: $ 13.22万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596476
• 关键词: Address; Adult; Behavior; Biological Availability; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Chronic stress; Clinical Research; Clinical Sciences; Data; Development; Diagnosis; Disease; Doppler Ultrasound; Early Intervention; Endothelium; Environment; Estradiol; Estrogens; Female; Funding; Future; Generalized Anxiety Disorder; Goals; Grant; Growth; Health; High Risk Woman; Hormonal; Hormones; Hour; Human; Hypertension; Impairment; Inosine Dialdehyde; Intervention; Kidney; Knowledge; Lead; Leg; Link; Master of Science; Measures; Mediating; Menopause; Menstrual cycle; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Movement; Muscle; Nerve; Neuronal Dysfunction; Nightmare; Nitric Oxide; Outcome; Panic Disorder; Pathway interactions; Patients; Periodicals; Peripheral; Physiological; Physiology; Plasma; Play; Post-Traumatic Stress Disorders; Premenopause; Prevalence; Prevention strategy; Production; Psyche structure; Research; Research Personnel; Research Project Grants; Resources; Rest; Risk; Role; Severities; Sleep; Sleep Apnea Syndromes; Sleep disturbances; Sleeplessness; Stress; Surveys; Sympathetic Nervous System; Testing; Training; Translational Research; Trauma; Trauma Research; United States National Institutes of Health; Universities; Vascular Diseases; Vulnerable Populations; Woman; Women' s Health; Work; actigraphy; arterial stiffness; arterial tonometry; aspirate; blood pressure elevation; brachial artery; cardioprotection; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; career development; comparison control; design; didactic education; experience; high risk; high risk population; improved; improvement on sleep; men; multidisciplinary; neural; poor sleep; programs; protective effect; renal artery; skills; stress disorder; therapy development; tonometry; trauma exposure; vascular abnormality; vasoconstriction; young woman

PROJECT SUMMARY The ultimate objective of this K01 proposal is to enable Dr. Ida Fonkoue to become an independent research investigator by 1) developing expertise in vascular, hormonal and sleep measures in humans; 2) acquiring scientific growth through a rigorous training plan, within an outstanding scientific environment that has a long tradition in translational vascular research; and 3) generating sufficient preliminary results to support an NIH R01 application. The candidate’s long-term goal is to build an NIH-funded research program in clinical and translational research in women’s health, studying derangements of vascular, neural and hormonal control, that contribute to the high rates of hypertension and cardiovascular disease (CVD) in women living with chronic stress exposure such as those with post-traumatic stress disorder (PTSD), generalized anxiety disorder or panic disorder. Over 7 million U.S. adults have PTSD, a disorder associated with a greater risk for hypertension and CVD. While healthy premenopausal women are relatively protected from CVD compared to men, a diagnosis of PTSD increases CVD risk in women by up to 3-fold. Understanding the mechanisms underlying CVD risk in women with PTSD is of paramount importance to develop intervention strategies aiming at protecting the future health of this vulnerable population. Based on our preliminary data, the working hypothesis of this project is that: PTSD inhibits nitric oxide bioavailability, resulting in decreased endothelial function, increased arterial stiffness and increased sympathetic activation; and that these changes are exacerbated by low estradiol levels and sleep disturbances. Aim 1 will identify alterations in SNS activity in premenopausal women with PTSD and determine if these alterations are a function of low E2 levels and sleep disturbances. Aim 2 will Identify alterations in vascular function in premenopausal women with PTSD and determine if these alterations are a function of low E2 levels and sleep disturbances. Emory University, where the PI’s entire mentoring team is located, boasts an intellectually rich research environment whose resources will be used to carry out the proposed research, including an NIH-funded Georgia Clinical and Translational Science Alliance (GA CTSA). During this K01 award, the PI will devote 75% effort to this project and career development-related activities as highlighted in her four years training and research plans. She will complete a Master of Science in Clinical Research offered by the GA CTSA and prepare future career development grant submission. This research project, combined with multidisciplinary mentorship, didactic education, and practical experience, will provide Dr. Fonkoue with the training and skills to become a successful independent investigator.

项目概要 这项 K01 提案的最终目标是使 Ida Fonkoue 博士成为一名独立研究人员 研究者：1) 发展人类血管、激素和睡眠测量方面的专业知识； 2）获取 通过严格的培训计划，在优秀的科学环境中实现科学成长 转化血管研究的传统； 3) 产生足够的初步结果来支持 NIH R01应用。候选人的长期目标是建立一个由 NIH 资助的临床和临床研究项目 女性健康的转化研究，研究血管、神经和荷尔蒙控制的紊乱， 导致慢性病女性患高血压和心血管疾病 (CVD) 的比例较高 压力暴露，例如患有创伤后应激障碍 (PTSD)、广泛性焦虑症或 恐慌症。 超过 700 万美国成年人患有创伤后应激障碍 (PTSD)，这是一种与高血压和高血压风险增加相关的疾病。 化学气相沉积。虽然与男性相比，健康的绝经前女性相对免受 CVD 的侵害，但诊断 创伤后应激障碍 (PTSD) 会使女性的 CVD 风险增加多达 3 倍。了解 CVD 风险的潜在机制 患有创伤后应激障碍 (PTSD) 的女性制定旨在保护未来的干预策略至关重要 这一弱势群体的健康。根据我们的初步数据，该项目的工作假设是 认为：PTSD 抑制一氧化氮生物利用度，导致内皮功能下降、动脉血流增加 僵硬和交感神经激活增加；低雌二醇水平会加剧这些变化 和睡眠障碍。目标 1 将确定患有 PTSD 的绝经前女性 SNS 活动的变化 确定这些改变是否是低 E2 水平和睡眠障碍的函数。目标 2 将确定 患有 PTSD 的绝经前妇女血管功能的改变，并确定这些改变是否是 低 E2 水平和睡眠障碍的功能。 PI 整个指导团队所在的埃默里大学拥有丰富的学术研究成果 其资源将用于开展拟议研究的环境，包括 NIH 资助的 佐治亚州临床和转化科学联盟 (GA CTSA)。本次K01奖励期间，PI将投入75% 她在四年的培训和工作中强调了对该项目的努力以及与职业发展相关的活动 研究计划。她将完成 GA CTSA 提供的临床研究理学硕士学位，并且 准备未来的职业发展补助金申请。该研究项目结合多学科 指导、教学教育和实践经验将为 Fonkoue 博士提供培训和技能 成为一名成功的独立调查员。