Emory/Georgia TB Research Advancement Center (TRAC)
埃默里/佐治亚州结核病研究促进中心 (TRAC)
基本信息
- 批准号:10596164
- 负责人:
- 金额:$ 97.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-23 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdministratorAdvanced DevelopmentAnimal ModelBasic ScienceBioinformaticsCause of DeathCenters for Disease Control and Prevention (U.S.)Cessation of lifeClinicalClinical ResearchClinical SciencesCollaborationsCommunicable DiseasesCommunicationCommunity HealthCountryCountyDataDevelopmentDiabetes MellitusDiagnosisDiseaseDrug KineticsDrug resistanceEnsureEpidemiologyEvaluationFosteringFoundationsFundingGoalsGrantHIVHealthHumanImmuneIncidenceIndividualInstitutionInterdisciplinary StudyInternationalInvestmentsKnowledgeLaboratoriesLeadershipMentorsMentorshipMissionMorehouse School of MedicineMycobacterium tuberculosisNational Institute of Allergy and Infectious DiseasePathogenesisPoliciesPopulation SciencesPreventionPrincipal InvestigatorPublic HealthResearchResearch PersonnelResearch Project GrantsResourcesScienceSpecimenStrategic PlanningSystems BiologyTechnologyTrainingTranslational ResearchTuberculosisUniversitiesVaccinesVirulenceVisionWorkWorld Health Organizationbiobankcomorbiditydata sharingepidemiology studyhuman population studyimprovedinnovationmultidisciplinarynext generationnonhuman primateorganizational structurepandemic diseaseprogramsresponsesuccesstooltransmission processtuberculosis diagnosticstuberculosis immunitytuberculosis treatment
项目摘要
Tuberculosis (TB) remains the leading infectious cause of death worldwide. Although the World Health
Organization (WHO) End TB Strategy sets ambitious goals to reduce TB incidence by 90% by 2035, we are
not on track to achieve them. We will need to “accelerate basic, translational, and clinical research to improve
understanding of TB and expedite the development of innovative new tools and strategies to improve
diagnosis, prevention, and treatment to end the TB pandemic,” as stated in the NIAID Strategic Plan for TB.
We propose the Emory/Georgia TB Research Advancement Center (TRAC) to catalyze and elevate
multidisciplinary basic, translational and clinical TB research at Emory University and partner institutions:
University of Georgia, Georgia Institute of Technology, Georgia State University, and Morehouse School of
Medicine. The Emory/Georgia TRAC builds upon the strong foundation established by the Emory TB Center,
created in 2020 in response to the growing number of investigators engaged in TB research. Across all the
Emory/Georgia TRAC institutions, there is a critical mass of 72 investigators engaged in TB research, and TB
PI/MPIs have received a total of over $104 million in TB research funding since 2010. Expertise in our TRAC
represents the full spectrum of TB science: TB transmission and epidemiology, human immunity to TB,
pathogenesis of TB using animal models (including non-human primates [NHP]), TB diagnostics, vaccines and
host-directed therapies, pharmacokinetics, drug-resistance and TB comorbidities (HIV, diabetes).
The Emory/Georgia TRAC will create added value by leveraging the scientific strengths at TRAC
institutions to catalyze and expand multidisciplinary TB research. The TRAC will provide financial, logistical,
and intellectual resources, pilot grants, and mentoring via a Developmental Core, Clinical & Population
Science Core, Basic & Translational Science Core, and Bioinformatics & Integrated Systems Biology
Core. These Cores will provide training and access to human study populations in high burden countries and
the US, resources for BSL3 laboratory-based Mtb and animal model research, including NHP, and
opportunities to utilize cutting-edge technologies and systems biology that can be leveraged for new
multidisciplinary and translational TB studies. Further, the TRAC will provide mentorship and support for early-
stage and non-TB investigators and create shared data and specimen biorepositories that will be a resource
for new study ideas and preliminary data. The Emory/Georgia TRAC, through its Core activities and resources,
will achieve these overarching aims: Aim 1: To catalyze and expand collaborative multidisciplinary TB
research among established basic, clinical and translational TB investigators and collaborators in the U.S. and
internationally; Aim 2: To capitalize on the strengths of the Emory/Georgia TRAC universities to grow and
diversify TB research in new directions; and Aim 3: To identify, train and mentor the next generation of TB
researchers and scientific leaders.
结核病(TB)仍然是世界范围内导致死亡的主要传染病。尽管世界卫生组织
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Neel Rajnikant Gandhi其他文献
Neel Rajnikant Gandhi的其他文献
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{{ truncateString('Neel Rajnikant Gandhi', 18)}}的其他基金
Emergence of bedaquiline, pretomanid and linezolid resistance after implementation of new drug-resistant tuberculosis regimens in South Africa
南非实施新的耐药结核病治疗方案后出现贝达喹啉、前托马尼和利奈唑胺耐药性
- 批准号:
10606031 - 财政年份:2022
- 资助金额:
$ 97.23万 - 项目类别:
Emory/Georgia TB Research Advancement Center (TRAC)
埃默里/佐治亚州结核病研究促进中心 (TRAC)
- 批准号:
10429400 - 财政年份:2022
- 资助金额:
$ 97.23万 - 项目类别:
Emory/Georgia TB Research Advancement Center (TRAC)
埃默里/佐治亚州结核病研究促进中心 (TRAC)
- 批准号:
10429399 - 财政年份:2022
- 资助金额:
$ 97.23万 - 项目类别:
Emory/Georgia TB Research Advancement Center (TRAC)
埃默里/佐治亚州结核病研究促进中心 (TRAC)
- 批准号:
10596165 - 财政年份:2022
- 资助金额:
$ 97.23万 - 项目类别:
Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but resistant to Mtb Infection
高度暴露但对 Mtb 感染具有抵抗力的个体的基因组学和代谢组学特征
- 批准号:
10208663 - 财政年份:2018
- 资助金额:
$ 97.23万 - 项目类别:
Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but resistant to Mtb Infection
高度暴露但对 Mtb 感染具有抵抗力的个体的基因组学和代谢组学特征
- 批准号:
10433919 - 财政年份:2018
- 资助金额:
$ 97.23万 - 项目类别:
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global Health
结核病、艾滋病毒和全球健康领域以患者为导向的研究指导
- 批准号:
10625368 - 财政年份:2014
- 资助金额:
$ 97.23万 - 项目类别:
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global Health
结核病、艾滋病毒和全球健康领域以患者为导向的研究指导
- 批准号:
9898222 - 财政年份:2014
- 资助金额:
$ 97.23万 - 项目类别:
Mentorship and Patient-Oriented Research in Tuberculosis, HIV and Global Health
结核病、艾滋病毒和全球健康领域的指导和以患者为导向的研究
- 批准号:
9064704 - 财政年份:2014
- 资助金额:
$ 97.23万 - 项目类别:
Mentorship and Patient-Oriented Research in Tuberculosis, HIV and Global Health
结核病、艾滋病毒和全球健康领域的指导和以患者为导向的研究
- 批准号:
8790305 - 财政年份:2014
- 资助金额:
$ 97.23万 - 项目类别:
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