Roles of Non-REM and REM sleep in facilitating visual perceptual learning
非快速眼动睡眠和快速眼动睡眠在促进视觉感知学习中的作用
基本信息
- 批准号:10596078
- 负责人:
- 金额:$ 39.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AgingApplications GrantsAreaBrainClinicalDevelopmentDiseaseGlutamatesGlutamineHumanInjuryLearningLeftMagnetic Resonance SpectroscopyMeasuresMethodsMonkeysPerceptual learningPerformancePilot ProjectsPlayPolysomnographyPrefrontal CortexProcessPsychophysicsREM SleepResearchRewardsRoleSignal TransductionSleepSumTechniquesTestingTrainingTraining ProgramsVisionVisualbehavior measurementclinical trainingexperienceextrastriate visual cortexgamma-Aminobutyric Acidimprovedinsightmesolimbic systemneuroimagingneuromechanismnon rapid eye movementresilienceretinotopicreward processingtoolvisual learning
项目摘要
Summary
This is a resubmission of the R01 grant proposal entitled “Roles of Non-REM and REM sleep in facilitating
visual perceptual learning”. Visual perceptual learning (VPL) refers to long-term performance enhancement on
a visual task as a result of visual experience. VPL not only provides substantial insight into visual and brain
plasticity but can also help in the development of an effective clinical tool to improve vision that is damaged or
declining due to disease or other causes. Thus, it is crucial to examine what factors facilitate VPL. Although a
number of studies have developed effective methods to facilitate VPL during training, much less is known about
the role that sleep plays in facilitating VPL (sleep facilitation). A better understanding of the roles and
mechanisms of sleep facilitation may be of enormous potential in improving visual training methods.
Our pilot study identified 3 types of facilitatory effects of sleep in VPL: offline performance gains, stabilization,
and post-sleep learning promotion. Aim 1 will investigate the underlying mechanism of these 3 sleep facilitation
effects by testing: H(ypothesis)1-1: The dorsolateral prefrontal cortex (dlPFC) and early visual areas (EVAs)
play a role in inducing offline performance gains during NREM sleep, H1-2: The ventromedial PFC (vmPFC) and
EVAs play a role in inducing stabilization during REM sleep, and H1-3: The vmPFC and EVAs play a role in
inducing postsleep learning promotion during REM sleep. This will be done by measuring the E/I ratio changes
in the retinotopically-defined EVAs, dlPFC, and vmPFC during NREM and REM sleep monitored by
polysomnography (PSG) and the correlation between the E/I ratio changes and each sleep facilitation effect. If
the results support these hypotheses, we will test whether the dlPFC and/or vmPFC plays a similar or different
role from EVAs in inducing sleep facilitation. To do so, we will compare the E/I ratio changes and the correlation
between each sleep facilitation effect and the E/I ratio changes in the dlPFC or vmPFC with those in EVAs.
Our other pilot study indicates that reward provided during training and posttraining sleep interact with each
other to enhance offline performance gains. This suggests that reward process is fundamentally involved in sleep
facilitation. Aim 2 will examine whether and how reward interacts with sleep to enhance sleep facilitation effects.
First, we will examine the other two sleep facilitation effects by testing H2-1: Reward and sleep interact with each
other and enhance stabilization, and H2-2: Reward and sleep interact with each other and enhance postsleep
learning promotion. Next, we will examine the mechanism underlying the interaction effect by testing H2-3: Sleep
facilitation effects, which may involve the dlPFC, vmPFC and EVAs during NREM and REM sleep, interact with
and are enhanced by reward. To test H2-1 to H-2-3, we will measure psychophysical performance for each sleep
facilitation effect as well as the E/I ratio changes in EVAs, vmPFC and dlPFC during NREM and REM sleep
monitored by PSG.
摘要
这是R01拨款提案的重新提交,该提案题为:非快速眼动睡眠和快速眼动睡眠在促进
视觉知觉学习“。视觉感知学习(VPL)指的是长期的学习成绩的提高
作为视觉体验的结果的视觉任务。VPL不仅提供了对视觉和大脑的实质性洞察
但也可以帮助开发一种有效的临床工具,以改善视力受损或
由于疾病或其他原因而衰弱的。因此,研究哪些因素促进了VPL是至关重要的。尽管一个
许多研究已经开发出在训练期间促进VPL的有效方法,但对此知之甚少
睡眠在促进睡眠促进(VPL)中的作用。更好地理解角色和
促进睡眠的机制可能在改进视觉训练方法方面具有巨大的潜力。
我们的初步研究确定了睡眠在VPL中的三种类型的促进作用:离线表现收益,稳定,
和睡眠后学习推广。目标1将研究这三种促进睡眠的潜在机制
测试效果:H(假位)1-1:背外侧前额叶皮质(DlPFC)和早期视觉区域(EVA)
在NREM睡眠期间,H1-2:腹内侧PFC(VmPFC)和
EVA在REM睡眠中起稳定作用,H1-3:vmPFC和EVA在REM睡眠中起作用
在快速眼动睡眠中诱导睡眠后学习促进。这将通过测量E/I比的变化来实现
在NREM和REM睡眠期间视网膜定位定义的EVA、dlPFC和vmPFC中,
多导睡眠图(PSG)及E/I比值变化与各项睡眠促进作用的相关性。如果
结果支持这些假设,我们将检验dlPFC和/或vmPFC是否发挥相似或不同的作用
EVAs在促进睡眠方面的作用。为此,我们将比较E/I比的变化和相关性
DlPFC或vmPFC的各睡眠促进效应及E/I比值与EVA的差异有统计学意义。
我们的另一项初步研究表明,训练期间提供的奖励和训练后的睡眠相互作用
其他以增强离线性能收益。这表明奖赏过程从根本上与睡眠有关
促进。目标2将研究奖励是否以及如何与睡眠相互作用,以增强睡眠促进效果。
首先,我们将通过测试H2-1来检查另外两个促进睡眠的效应:奖励和睡眠与它们之间的相互作用
其他和增强稳定性,以及H2-2:奖励和睡眠相互作用,增强睡眠后
学习促进。接下来,我们将通过测试H2-3:睡眠来检查交互作用的潜在机制
易化效应可能涉及NREM和REM睡眠中的dlPFC、vmPFC和EVA,它们相互作用
并因奖励而得到加强。为了测试H2-1到H-2-3,我们将测量每个睡眠的心理物理性能
NREM和REM睡眠时EVA、vmPFC和dlPFC的易化效应及E/I比值的变化
由PSG监控。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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YUKA SASAKI其他文献
Prostacyclin synthase deficiency suppressed obesity in mice
前列环素合酶缺乏抑制小鼠肥胖
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
YUKA SASAKI;Moe Akatsu;Yuri Yamakawa;Chieko Yokoyama;Shuntaro Hara - 通讯作者:
Shuntaro Hara
YUKA SASAKI的其他文献
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{{ truncateString('YUKA SASAKI', 18)}}的其他基金
Roles of Non-REM and REM sleep in facilitating visual perceptual learning
非快速眼动睡眠和快速眼动睡眠在促进视觉感知学习中的作用
- 批准号:
10392488 - 财政年份:2021
- 资助金额:
$ 39.88万 - 项目类别:
Roles of Non-REM and REM sleep in facilitating visual perceptual learning
非快速眼动睡眠和快速眼动睡眠在促进视觉感知学习中的作用
- 批准号:
10205345 - 财政年份:2021
- 资助金额:
$ 39.88万 - 项目类别:
The first night effect of sleep and visual plasticity
睡眠的初夜效应与视觉可塑性
- 批准号:
9761539 - 财政年份:2018
- 资助金额:
$ 39.88万 - 项目类别: