Medical Imaging of Peripheral Nerve Injury and Repair

周围神经损伤与修复的医学影像

• 批准号: 10595628
• 负责人: Sameer B. Shah
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10595628
• 关键词: Acute; Anatomy; Architecture; Axon; Biological; Biomechanics; Cadaver; Carpal Tunnel Syndrome; Cervical spinal cord injury; Chronic; Clinic; Clinical; Complex; Data; Decision Making; Deterioration; Development; Diagnosis; Disease; Environment; Excision; Extracellular Matrix; Fascicle; Funding; General Population; Geometry; Growth; Human; Image; Imaging Techniques; Individual; Injury; Limb structure; Magnetic Resonance Imaging; Medical Imaging; Methods; Modality; Modeling; Monitor; Morphology; Muscle; Muscular Atrophy; Myelin; Natural regeneration; Nerve; Nerve Degeneration; Nerve Regeneration; Nerve Transfer; Neuromuscular Diseases; Neuropathy; Operative Surgical Procedures; Outcome; Pain; Patients; Peripheral Nerves; Peripheral nerve injury; Physical therapy; Prognosis; Prospective Studies; Protocols documentation; Rattus; Recovery; Recovery of Function; Rehabilitation therapy; Research; Resolution; Sensory; Soldier; Spinal cord injury; Structure; Structure of ulnar nerve; Surgeon; System; Testing; Time; Tissues; Traumatic injury; Ultrasonography; Veterans; Work; clinical efficacy; efficacy testing; experience; functional outcomes; human model; iatrogenic injury; imaging approach; improved; injury and repair; innovation; limb injury; long term recovery; median nerve; military veteran; motor impairment; muscular structure; nerve damage; nerve injury; nerve repair; neuromuscular; novel; patient population; peripheral nerve damage; peripheral nerve regeneration; pre-clinical; predictive tools; prognostic tool; prospective; quantitative ultrasound; regenerative; repaired; sciatic nerve injury; secondary outcome; success; tool; ultrasound

Peripheral nerve damage is a debilitating consequence of both traumatic injury to the extremities of soldiers, and a secondary outcome following spinal cord injury (SCI). Equally devastating, for both the Veteran and general population, is nerve damage during excision of surrounding tissue, disease, or iatrogenic injury. Functional recovery from nerve damage is often incomplete, resulting in impaired motor function, sensory loss, and pain. Recovery is especially poor for chronic nerve injuries, which can result from unrepaired nerves or from delayed or failed primary repair. A major challenge in treating nerve injury is the current lack of effective methods to medically image nerves. As a consequence, surgeons are unable to accurately assess the extent of nerve injury, plan surgical intervention in an informed and data-driven manner, or assess the success of nerve repair at early time points, to predict long-term recovery. We have developed innovative quantitative strategies for nerve imaging, which overcome challenges created by the complex structure and architecture of nerves. Our approach employs two widely deployed clinical modalities, ultrasound (US) and magnetic resonance imaging (MRI). Our imaging approach is motivated by strong preliminary data demonstrating that quantitative US (qUS) and MRI (qMRI) are powerful and clinically feasible strategies for monitoring nerve structure and composition at high-resolution and with high sensitivity. These approaches are also intended to provide non-invasive surrogates for biological changes that occur during nerve degeneration and regeneration, but which cannot be evaluated in patients. To establish the validity and utility of qUS and qMRI in evaluating nerve structure and composition in a clinical setting, we will address the following specific aims in rat (Aim 1) and human (Aim 2) models of acute and chronic nerve injury: 1) To test the efficacy of quantitative US and MR imaging strategies in assessing neuromuscular morphology and composition during peripheral nerve degeneration and following repair of acute and chronic models of rat sciatic nerve injury. 2) To test the clinical efficacy of quantitative US and MR imaging strategies in assessing neuromuscular morphology and composition in acute and chronic models of human median and ulnar nerve injury immediately prior to surgical repair. Our approach has the potential to transform the diagnosis and treatment of nerve injury. Immediate clinical impacts include: (i) objective guidance on deciding whether to perform nerve repair or nerve transfer surgery; (ii) predicting and monitoring the efficacy of nerve repair; (iii) guidance for post-op rehabilitation protocols. This work will also set the stage for a prospective study in which imaging strategies will be deployed as prognostic tools for predicting the efficacy of neuromuscular recovery following nerve repair, towards improved treatment of nerve injury in Veteran and general populations. More broadly, our nerve imaging strategy will aid in the diagnosis and prediction of nerve structure and damage for a wider array of neuropathies and nerve diseases.

外周神经损伤是四肢创伤性损伤的一种衰弱性后果