Medical Imaging of Peripheral Nerve Injury and Repair

周围神经损伤与修复的医学影像

基本信息

  • 批准号:
    10117512
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-10-01 至 2024-09-30
  • 项目状态:
    已结题

项目摘要

Peripheral nerve damage is a debilitating consequence of both traumatic injury to the extremities of soldiers, and a secondary outcome following spinal cord injury (SCI). Equally devastating, for both the Veteran and general population, is nerve damage during excision of surrounding tissue, disease, or iatrogenic injury. Functional recovery from nerve damage is often incomplete, resulting in impaired motor function, sensory loss, and pain. Recovery is especially poor for chronic nerve injuries, which can result from unrepaired nerves or from delayed or failed primary repair. A major challenge in treating nerve injury is the current lack of effective methods to medically image nerves. As a consequence, surgeons are unable to accurately assess the extent of nerve injury, plan surgical intervention in an informed and data-driven manner, or assess the success of nerve repair at early time points, to predict long-term recovery. We have developed innovative quantitative strategies for nerve imaging, which overcome challenges created by the complex structure and architecture of nerves. Our approach employs two widely deployed clinical modalities, ultrasound (US) and magnetic resonance imaging (MRI). Our imaging approach is motivated by strong preliminary data demonstrating that quantitative US (qUS) and MRI (qMRI) are powerful and clinically feasible strategies for monitoring nerve structure and composition at high-resolution and with high sensitivity. These approaches are also intended to provide non-invasive surrogates for biological changes that occur during nerve degeneration and regeneration, but which cannot be evaluated in patients. To establish the validity and utility of qUS and qMRI in evaluating nerve structure and composition in a clinical setting, we will address the following specific aims in rat (Aim 1) and human (Aim 2) models of acute and chronic nerve injury: 1) To test the efficacy of quantitative US and MR imaging strategies in assessing neuromuscular morphology and composition during peripheral nerve degeneration and following repair of acute and chronic models of rat sciatic nerve injury. 2) To test the clinical efficacy of quantitative US and MR imaging strategies in assessing neuromuscular morphology and composition in acute and chronic models of human median and ulnar nerve injury immediately prior to surgical repair. Our approach has the potential to transform the diagnosis and treatment of nerve injury. Immediate clinical impacts include: (i) objective guidance on deciding whether to perform nerve repair or nerve transfer surgery; (ii) predicting and monitoring the efficacy of nerve repair; (iii) guidance for post-op rehabilitation protocols. This work will also set the stage for a prospective study in which imaging strategies will be deployed as prognostic tools for predicting the efficacy of neuromuscular recovery following nerve repair, towards improved treatment of nerve injury in Veteran and general populations. More broadly, our nerve imaging strategy will aid in the diagnosis and prediction of nerve structure and damage for a wider array of neuropathies and nerve diseases.
外周神经损伤是四肢创伤性损伤的一种衰弱性后果

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Sameer B. Shah其他文献

Implants in rhinoplasty.
鼻整形术中的植入物。
  • DOI:
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    0
  • 作者:
    C. Maas;N. Monhian;Sameer B. Shah
  • 通讯作者:
    Sameer B. Shah
Enhanced preservation of the auditory nerve following cochlear perfusion with nerve growth factors.
用神经生长因子进行耳蜗灌注后增强听神经的保存。
  • DOI:
  • 发表时间:
    1995
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Robert A. Schindler;H. Gladstone;N. Scott;G. Hradek;H. Williams;Sameer B. Shah
  • 通讯作者:
    Sameer B. Shah
Mechanical properties of the lamprey spinal cord: uniaxial loading and physiological strain.
七鳃鳗脊髓的机械特性:单轴载荷和生理应变。
  • DOI:
    10.1016/j.jbiomech.2013.06.028
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Carlos Luna;Laura Detrick;Sameer B. Shah;A. Cohen;H. Aranda‐Espinoza
  • 通讯作者:
    H. Aranda‐Espinoza
Evidence for increased myofibrillar mobility in desmin-null mouse skeletal muscle.
无结蛋白小鼠骨骼肌中肌原纤维活动性增加的证据。
  • DOI:
  • 发表时间:
    2002
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Sameer B. Shah;F. Su;K. Jordan;D. Milner;J. Fridén;Y. Capetanaki;R. Lieber
  • 通讯作者:
    R. Lieber
Chemotropism among populations of yeast cells with spatiotemporal resolution in a biofabricated microfluidic platform.
在生物制造的微流体平台中具有时空分辨率的酵母细胞群体的趋化性。
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Thanh Vo;Sameer B. Shah;John S. Choy;Xiaolong Luo
  • 通讯作者:
    Xiaolong Luo

Sameer B. Shah的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Sameer B. Shah', 18)}}的其他基金

Medical Imaging of Peripheral Nerve Injury and Repair
周围神经损伤与修复的医学影像
  • 批准号:
    10595628
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Medical Imaging of Peripheral Nerve Injury and Repair
周围神经损伤与修复的医学影像
  • 批准号:
    10426042
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Imaging Strategies To Improve Diagnosis and Treatment of Entrapment Neuropathy
改善卡压神经病诊断和治疗的影像策略
  • 批准号:
    9525148
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Imaging Strategies To Improve Diagnosis and Treatment of Entrapment Neuropathy
改善卡压神经病诊断和治疗的影像策略
  • 批准号:
    9350565
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Novel Modular Nerve Lengthening Device for Peripheral Nerve Regeneration
用于周围神经再生的新型模块化神经延长装置
  • 批准号:
    8983045
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Novel Modular Nerve Lengthening Device for Peripheral Nerve Regeneration
用于周围神经再生的新型模块化神经延长装置
  • 批准号:
    9172207
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Influence of cargo geometry on axonal transport kinetics
货物几何形状对轴突运输动力学的影响
  • 批准号:
    6893379
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:
Influence of cargo geometry on axonal transport kinetics
货物几何形状对轴突运输动力学的影响
  • 批准号:
    6792234
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了