Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities
破碎的早期生活经历、异常的电路成熟、情感脆弱
基本信息
- 批准号:10595603
- 负责人:
- 金额:$ 48.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-06-17 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AccountabilityAddressAdultAmygdaloid structureAnhedoniaAnimalsBrainBrain imagingCohort StudiesCollaborationsComputer ModelsDataData SetData Storage and RetrievalDevelopmentDiffusionDiffusion Magnetic Resonance ImagingDimensionsEmotionalFunctional Magnetic Resonance ImagingGoalsHippocampusHumanImageImaging DeviceImaging TechniquesLifeLife ExperienceLinkMRI ScansMagnetic Resonance ImagingMental disordersMethodsModelingPathway interactionsPatternPhasePopulationProcessPsyche structurePsychopathologyQuality ControlRattusResolutionRestRewardsRiskRodentScanningScientistSecuritySensorySignal TransductionStatistical ModelsStructureSystemTestingThickWorkbrain circuitrycohortconnectomeearly life adversitygraph theoryhigh riskimaging facilitiesinnovationinsightlow socioeconomic statusmaternal depressionmetermultidisciplinarymultimodalityneuroimagingneuropsychiatric disordernovelpleasurepredictive modelingprismaresiliencereward circuitrysexultra high resolutionyoung adult
项目摘要
This high-impact Center revised renewal proposal integrates a multidisciplinary group of scientists to
investigate the developmental origins of vulnerability to mental illness, with a focus on perturbed environmental
/ sensory signals impacting brain circuits during sensitive developmental periods. It posits that unpredictable,
fragmented sensory signals to the developing brain (FRAG), constitute a previously unrecognized indicator of
early-life adversity that impacts brain circuit maturation across species, provoking anhedonia and vulnerability
to psychopathology. The overarching goal of the Imaging Core is to enable the Center to use imaging tools to
address the as yet unknown mechanistic pathways by which FRAG may lead to anhedonia and other
vulnerabilities to psychopathology. The Core will work with Projects 1-4 to conduct translational neuroimaging
across species and cohorts, and with the BCDM core it will develop computational and statistical models to
provide novel insights into circuit mechanisms that underlie the impact of FRAG on the developing brain.
The core will:
1. Acquire, process, analyze, store, and make available all high-resolution structural, functional, and diffusion
MRI data on human and rodent cohorts, in support of Projects 1-4 and to address imaging-related hypotheses.
2. Identify aberrant and sex-specific patterns and trajectories in structure, function, and connectivity of
pleasure/reward circuitry that link early life FRAG to anhedonia and risk for psychopathology, using
innovative multimodal MRI approaches across cohorts, projects, and species.
3. Develop a rich dataset of whole-brain-derived imaging metrics using network connectomics and, working
with the BCDM Core, integrate these metrics in statistical models that predict anhedonia and psychopathology
from FRAG-associated aberrations in brain circuitry.
Whole brain functional and structural connectomes will be created using diffusion and resting state fMRI data
to assess dynamic and stable reorganization of circuits as a function of FRAG. Network approaches
such as graph theory based on structural and functional connectomes will be used to quantify overall shifts in
brain circuits (e.g. rich club and small world networks). The BCDM and Imaging cores, guided by expertise of
Center consultant, Prof. Olaf Sporns, will collaborate on employing these methods for integration into models
that take into account all other data types to predict anhedonia and psychopathology from FRAG and the
associated brain circuitry alterations. These data-driven approaches will additionally allow us to examine
alternative and secondary hypotheses.
这个高影响力的中心修订的更新提案整合了一个多学科的科学家小组
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael A Yassa其他文献
Michael A Yassa的其他文献
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{{ truncateString('Michael A Yassa', 18)}}的其他基金
Testing the role of tau pathology in disrupting hippocampal CA1 memory function in older adults at risk for Alzheimer’s disease
测试 tau 病理学在破坏有阿尔茨海默病风险的老年人海马 CA1 记忆功能中的作用
- 批准号:
10353910 - 财政年份:2022
- 资助金额:
$ 48.11万 - 项目类别:
Testing the role of tau pathology in disrupting hippocampal CA1 memory function in older adults at risk for Alzheimer’s disease
测试 tau 病理学在破坏有阿尔茨海默病风险的老年人海马 CA1 记忆功能中的作用
- 批准号:
10554263 - 财政年份:2022
- 资助金额:
$ 48.11万 - 项目类别:
Assessing the role of cerebrovascular brain injury and dysfunction in Alzheimer’s disease pathogenesis in the BEACoN Cohort
在 BEACoN 队列中评估脑血管损伤和功能障碍在阿尔茨海默病发病机制中的作用
- 批准号:
10604863 - 财政年份:2017
- 资助金额:
$ 48.11万 - 项目类别:
Selective age-related vulnerability in human perirhinal and lateral entorhinal cortices
人类鼻周和外侧内嗅皮质的选择性年龄相关脆弱性
- 批准号:
8807575 - 财政年份:2015
- 资助金额:
$ 48.11万 - 项目类别:
Selective age-related vulnerability in human perirhinal and lateral entorhinal cortices
人类鼻周和外侧内嗅皮质的选择性年龄相关脆弱性
- 批准号:
9143635 - 财政年份:2015
- 资助金额:
$ 48.11万 - 项目类别:
Neural Mechanisms of Emotional Memory Modulation in Major Depression
重度抑郁症情绪记忆调节的神经机制
- 批准号:
9110330 - 财政年份:2014
- 资助金额:
$ 48.11万 - 项目类别:
Neural Mechanisms of Emotional Memory Modulation in Major Depression
重度抑郁症情绪记忆调节的神经机制
- 批准号:
8818094 - 财政年份:2014
- 资助金额:
$ 48.11万 - 项目类别:
Neural Mechanisms of Emotional Memory Modulation in Major Depression
重度抑郁症情绪记忆调节的神经机制
- 批准号:
8922055 - 财政年份:2014
- 资助金额:
$ 48.11万 - 项目类别:
Neural Mechanisms of Emotional Memory Modulation in Major Depression
重度抑郁症情绪记忆调节的神经机制
- 批准号:
9281914 - 财政年份:2014
- 资助金额:
$ 48.11万 - 项目类别:
Fragmented early-life experiences, aberrant circuit maturation, emotional vulnerabilities
破碎的早期生活经历、异常的电路成熟、情感脆弱
- 批准号:
10379272 - 财政年份:2013
- 资助金额:
$ 48.11万 - 项目类别:
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