3D micro-physiological systems for identification of therapeutic myokines
用于识别治疗性肌因子的 3D 微生理系统
基本信息
- 批准号:10595294
- 负责人:
- 金额:$ 53.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-22 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAccountingAcuteAnimal ModelArteriesBindingBiochemicalBiological MarkersBiological ModelsBiological ProcessBiologyBiomimeticsBiopsyBloodCardiacCardiovascular DiseasesCategoriesCell physiologyCellsChemistryChronicCirculationCommunicationCuesDementiaDetectionDiseaseDoseEndocrineEndocrine GlandsEngineeringExerciseExercise TherapyFactor AnalysisGeneticGoalsHindlimbHuman bodyHypoxiaIn VitroIschemiaIschemic PreconditioningLabelLeftLife StyleLigationLimb structureMalignant NeoplasmsMechanicsMedicineMethionine-tRNA LigaseMicrofluidicsMuscleMuscle ContractionMuscle ProteinsMyocardial IschemiaMyocardiumMyopathyNatureNon-Insulin-Dependent Diabetes MellitusObesityOperative Surgical ProceduresOpticsOrganOutcomePatientsPhysical activityPhysiologicalPoint MutationPost-Translational Protein ProcessingProtein BiosynthesisProteinsProteomeProteomicsReporterReportingResearchRhodopsinRoleSamplingSecond Messenger SystemsSkeletal MuscleSystemTestingTherapeuticTimeTissuesTourniquetsTransgenesTranslatingValidationVascularizationWorkcell typecost effectivecytokinedetection platformendurance exerciseexercise regimenexercise trainingin vivoinnovationmicrophysiology systemminimally invasivemouse modelmuscle regenerationmyogenesisnoveloptogeneticsprotective effectpublic health relevancereceptorsarcopeniasedentaryskeletalspatiotemporaltooltranslational potentialtreadmill
项目摘要
PROJECT SUMMARY
Skeletal muscle is a highly vascularized tissue that can secrete cytokines and proteins, collectively termed as
myokines. Despite the tremendous potential for translation, due to the dynamic nature of blood-borne factors,
reliable identification of these humoral factors remains a major hurdle. To overcome this challenge, Dr. Jang and
Dr. Park’s group will leverage advanced microengineering approaches to build a 3D microfluidic muscle circuit
that can control mechanical and biochemical cues in the physiologically relevant 3D microenvironment. In this
proposal, two groups will further refine and upgrade the in vitro muscle platform by integrating a cell-type-specific
protein labeling system (MetRSL2774G transgene) to precisely identify the muscle secretome responsible for the
muscle-to-remote organ communications. In addition, the team will also engineer an exercise-induced myokine
reporter system using an optogenetic actuator (Channel-rhodopsin 2) co-expressed with protein labeling
construct, MetRSL274G. Using these approaches, proposed studies will identify novel contraction-induced
myokines that are responsible for the beneficial effects of exercise. Finally, the research team seeks to identify
muscle proteomes that exert their action on muscle-heart crosstalk, especially in the context of ischemic
preconditioning. The successful outcomes of this project will have far and broad implications in muscle biology
and medicine. This minimally invasive 3D microphysiological system can be exploited in a variety of studies
testing systemic tissue interactions. More importantly, upon validation, the experimental approach used in this
proposal can be translated to develop myokine-based therapeutics for late-onset lifestyle disorders.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Young Charles Jang其他文献
Young Charles Jang的其他文献
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{{ truncateString('Young Charles Jang', 18)}}的其他基金
Engineered Heterochronic Parabiosis on 3D Microphysiological Systems
3D 微生理系统上的工程异时共生
- 批准号:
10207946 - 财政年份:2021
- 资助金额:
$ 53.41万 - 项目类别:
Engineered Heterochronic Parabiosis on 3D Microphysiological Systems
3D 微生理系统上的工程异时共生
- 批准号:
10380776 - 财政年份:2021
- 资助金额:
$ 53.41万 - 项目类别:
Engineered Heterochronic Parabiosis on 3D Microphysiological Systems
3D 微生理系统上的工程异时共生
- 批准号:
10663683 - 财政年份:2021
- 资助金额:
$ 53.41万 - 项目类别:
Engineered Heterochronic Parabiosis on 3D Microphysiological Systems
3D 微生理系统上的工程异时共生
- 批准号:
10544776 - 财政年份:2021
- 资助金额:
$ 53.41万 - 项目类别:
Replicating heterochronic parabiosis on a chip for testing anti-geronic factors
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9914196 - 财政年份:2019
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Implantable biofunctional hydrogel for muscle stem cell transplantation
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9375058 - 财政年份:2017
- 资助金额:
$ 53.41万 - 项目类别:
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