3D micro-physiological systems for identification of therapeutic myokines

用于识别治疗性肌因子的 3D 微生理系统

基本信息

  • 批准号:
    10595294
  • 负责人:
  • 金额:
    $ 53.41万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-05-22 至 2028-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Skeletal muscle is a highly vascularized tissue that can secrete cytokines and proteins, collectively termed as myokines. Despite the tremendous potential for translation, due to the dynamic nature of blood-borne factors, reliable identification of these humoral factors remains a major hurdle. To overcome this challenge, Dr. Jang and Dr. Park’s group will leverage advanced microengineering approaches to build a 3D microfluidic muscle circuit that can control mechanical and biochemical cues in the physiologically relevant 3D microenvironment. In this proposal, two groups will further refine and upgrade the in vitro muscle platform by integrating a cell-type-specific protein labeling system (MetRSL2774G transgene) to precisely identify the muscle secretome responsible for the muscle-to-remote organ communications. In addition, the team will also engineer an exercise-induced myokine reporter system using an optogenetic actuator (Channel-rhodopsin 2) co-expressed with protein labeling construct, MetRSL274G. Using these approaches, proposed studies will identify novel contraction-induced myokines that are responsible for the beneficial effects of exercise. Finally, the research team seeks to identify muscle proteomes that exert their action on muscle-heart crosstalk, especially in the context of ischemic preconditioning. The successful outcomes of this project will have far and broad implications in muscle biology and medicine. This minimally invasive 3D microphysiological system can be exploited in a variety of studies testing systemic tissue interactions. More importantly, upon validation, the experimental approach used in this proposal can be translated to develop myokine-based therapeutics for late-onset lifestyle disorders.
项目总结

项目成果

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Young Charles Jang其他文献

Young Charles Jang的其他文献

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{{ truncateString('Young Charles Jang', 18)}}的其他基金

Engineered Heterochronic Parabiosis on 3D Microphysiological Systems
3D 微生理系统上的工程异时共生
  • 批准号:
    10207946
  • 财政年份:
    2021
  • 资助金额:
    $ 53.41万
  • 项目类别:
Engineered Heterochronic Parabiosis on 3D Microphysiological Systems
3D 微生理系统上的工程异时共生
  • 批准号:
    10380776
  • 财政年份:
    2021
  • 资助金额:
    $ 53.41万
  • 项目类别:
Engineered Heterochronic Parabiosis on 3D Microphysiological Systems
3D 微生理系统上的工程异时共生
  • 批准号:
    10663683
  • 财政年份:
    2021
  • 资助金额:
    $ 53.41万
  • 项目类别:
Engineered Heterochronic Parabiosis on 3D Microphysiological Systems
3D 微生理系统上的工程异时共生
  • 批准号:
    10544776
  • 财政年份:
    2021
  • 资助金额:
    $ 53.41万
  • 项目类别:
Replicating heterochronic parabiosis on a chip for testing anti-geronic factors
在芯片上复制异时联体共生以测试抗老年因子
  • 批准号:
    9914196
  • 财政年份:
    2019
  • 资助金额:
    $ 53.41万
  • 项目类别:
Implantable biofunctional hydrogel for muscle stem cell transplantation
用于肌肉干细胞移植的可植入生物功能水凝胶
  • 批准号:
    9375058
  • 财政年份:
    2017
  • 资助金额:
    $ 53.41万
  • 项目类别:

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