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Using vortical airflow to pressurize the upper airway without a tight seal during CPAP therapy

在 CPAP 治疗期间使用涡流气流对上呼吸道加压，无需紧密密封

基本信息

批准号：
10594761
负责人：
Liran Oren
金额：
$ 40.18万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-03-05 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10594761
关键词：
Aerospace Engineering Affect Air Movements Breathing Cannulas Cardiovascular Diseases Chronic Clinical effectiveness Collaborations Computers Continuous Positive Airway Pressure Data Development Devices Dimensions Ensure Equipment Evaluation Face Feedback Goals Habits Human Image Individual Industry Marketing Masks Muscle relaxation phase Nose Obstruction Obstructive Sleep Apnea Patients Penetration Pharyngeal structure Phenotype Physiologic pulse Physiological Population Positioning Attribute Production Property Reapplication Recommendation Risk Security Sleep Sleep Apnea Syndromes Structure System Technology Testing Treatment Failure Universities Work adverse outcome airway obstruction base clinical efficacy commercialization compliance behavior data acquisition design laptop manufacture new technology non-compliance pharynx muscle positive airway pressure preference pressure prevent product development programs prototype pulmonary function seal soft tissue stem therapy adherence

项目摘要

PROJECT SUMMARY Despite the clinical effectiveness of Continuous Positive Airway Pressure (CPAP) for obstructive sleep apnea (OSA), patient compliance with the therapy remains a major cause of treatment failure. This chronic sleep-related breathing disorder that affects 5-10% of the population is associated with various serious adverse outcomes, including cardiovascular diseases. OSA involves a decrease or complete halt in airflow despite an ongoing breathing effort. It occurs when muscles relax during sleep, causing soft tissues in the posterior pharynx to collapse and obstruct the upper airway. CPAP, which is broadly considered first-line therapy for OSA, keeps the upper airway open with positive airway pressure to prevent airway obstruction by the collapse of the soft tissues. However, CPAP requires a tight seal between the mask and the patient's face closed system to maintain airway pressure. Although effective when used consistently, CPAP is not well tolerated by many patients largely due to the discomfort of the tight-fitting mask of current devices. A promising new development derives from our recent work based on the re-application of “vortical airflow,” a flow control mechanism commonly used in aerospace engineering applications. The unique aerodynamic properties of vortical airflow enable it to pressurize the upper airways without the need for a tight-fitting mask. The current project is designed to accomplish two critical milestones. First, the current prototype will be advanced to function as a stand-alone unit with an overall size similar to currently marketed CPAP devices. Second, it will demonstrate that the nasal interface of the new prototype is more comfortable than CPAP masks.

项目总结