Validation of Mesoscopic Imaging to Predict Cutaneous Carcinogenesis and its Therapeutic Response
验证细观成像预测皮肤癌发生及其治疗反应
基本信息
- 批准号:10595503
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-10-01 至 2023-09-30
- 项目状态:已结题
- 来源:
- 关键词:Actinic keratosisAcuteAgeAgingAreaBiochemicalBiological ModelsBiopsyBlood VesselsBlood VolumeCaringCause of DeathCharacteristicsChronicClinicClinicalClinical TreatmentColon CarcinomaCreamCutaneousDNA Repair EnzymesDNA Sequence AlterationDermabrasionDermalDermatologyDiagnosisDiagnosticEffectivenessElderlyExhibitsFibroblastsFinancial HardshipFluorouracilGeneral PopulationGoalsHealthcare SystemsHemoglobinHistologicHistologyHot SpotHumanIL8 geneImageIncidenceInsulin-Like Growth Factor IInterleukin-6InterventionLasersMalignant NeoplasmsMalignant neoplasm of esophagusMalignant neoplasm of lungMapsMeasurementMethodologyModelingMonitorMorbidity - disease rateMutationNeoplasmsOpticsOrgan TransplantationOrgan failurePUVA PhotochemotherapyPatientsPhenotypePhysiologicalPilot ProjectsPrediction of Response to TherapyPreventionProliferatingReportingResearchResearch PersonnelRiskRisk FactorsSiteSkinSkin CancerSkin CarcinomaSolidSourceSpatial Frequency Domain ImagingSpottingsStainsSun ExposureTNF geneTP53 geneTestingThymidineTimeTissuesTransplant RecipientsUV Radiation ExposureUltraviolet B RadiationValidationVeteransbody systemcancer typecarcinogenesischemotherapycohortcytokinedimerearly detection biomarkersexperiencehigh riskhigh risk populationimaging platformimaging systemimprovedinsightkeratinocytemortalitymutantneoplasticnon-invasive imagingnovelpatient responsepreclinical studypredicting responsepremalignantquantitative imagingradiation responserisk predictionrisk stratificationsenescenceskin photodamagespectrographtooltranscriptometreatment responsewound
项目摘要
PROJECT SUMMARY
Actinic neoplasia (precancerous actinic keratosis and non-melanoma skin cancer) is the most common type of
human neoplasia, and the most common diagnosis in VA dermatology clinics. We and other groups have
characterized the mechanisms by which aging and ultraviolet B radiation (UVB) contribute to actinic neoplasia.
In particular, human skin at high risk for actinic neoplasia exhibits biochemical features, including decreased
keratinocyte expression of DNA repair enzymes, increased numbers of senescent fibroblasts with lower levels
of fibroblast IGF-1, and increased fibroblast cytokines including IL-6, IL-8 and TNF. Moreover, at risk skin
responds to UVB by generating basal keratinocytes proliferating while still harboring DNA mutations. This
revised VA Merit application will leverage our recent findings that a noninvasive, multi-spectral, mesoscopic
imaging platform could potentially identify clinically normal-appearing skin at risk for actinic neoplasia. This
proposal also provides evidence that mesoscopic imaging could have use in quantifying field carcinogenesis. To
that end, two specific aims will test the hypothesis that mesoscopic imaging will be able to discern skin with
biochemical and functional characteristics of tissue at high risk for actinic neoplasia. The first aim consists of
two parts. In the first part, mesoscopic imaging will be used to predict areas of at-risk vs. normal skin, which will
be tested with biopsies and non-invasive transcriptome analysis to compare imaging parameter-based
predictions against biochemical, histological and functional features associated with skin at high risk for actinic
neoplasia. In the second part of Aim 1 we will take advantage of our recent findings that wounding of photo-
damaged geriatric skin with fractionated laser resurfacing normalizes the actinic neoplastic
biochemical/histological changes. We will leverage these findings by conducting mesoscopic imaging of laser-
wounded vs unwounded skin in geriatric subjects with photo-damaged skin. The second aim will test the ability
of mesoscopic imaging to quantify the effectiveness of topical photodynamic therapy (PDT) performed or
chemotherapy agent 5-fluorouracil cream on subjects with multiple actinic keratosis requiring field therapy.
Additionally, subjects at high risk for actinic neoplasia not treated with field therapy will be monitored
longitudinally in clinics by serial mesoscopic imaging. These three strategies in Aim 2 will test if this noninvasive
imaging can predict where actinic keratosis will arise and assess if mesoscopic imaging has use in the clinic for
quantifying skin at-risk for actinic neoplasia and actinic keratosis. The overall goal is to establish a fast, wide-
field, multi-spectral imaging system that can provide quantitative imaging parameters for monitoring human skin
non-invasively. If successful, these studies will validate a valuable clinical tool that can stratify risk of actinic
neoplasia even when skin appears clinically normal. Moreover, this non-invasive, image-based contrast
mapping approach could serve to propel research in field cancerization using skin as a model system, which
could be adapted to other organ systems such as colon, esophagus and lung cancers. These studies will
improve the care of veterans served in our dermatology clinics. This proposal will also provide valuable tools for
both the study and monitoring of many cancer types found in US Veterans.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey B. Travers其他文献
Relevance of the Platelet-activating factor system in chemical warfare agents-induced effects
血小板活化因子系统在化学战剂诱导效应中的相关性
- DOI:
10.1016/j.freeradbiomed.2024.12.037 - 发表时间:
2025-02-16 - 期刊:
- 影响因子:8.200
- 作者:
Anita Thyagarajan;Jeffrey B. Travers;Ravi P. Sahu - 通讯作者:
Ravi P. Sahu
Topical Photodynamic Therapy Generates Bioactive Microvesicle Particles: Evidence for a Pathway Involved in Immunosuppressive Effects
局部光动力疗法产生生物活性微泡颗粒:参与免疫抑制作用途径的证据
- DOI:
10.1016/j.jid.2022.12.018 - 发表时间:
2023-07-01 - 期刊:
- 影响因子:5.700
- 作者:
Oladayo A. Oyebanji;Chad Brewer;Sharlo Bayless;Benjamin Schmeusser;Danielle A. Corbin;Courtney E.W. Sulentic;Catherine M.T. Sherwin;Yanfang Chen;Christine M. Rapp;Elizabeth E. Cates;Yuhan Long;Jeffrey B. Travers;Craig A. Rohan - 通讯作者:
Craig A. Rohan
Case Studies of Sustained Remission of Membranous Glomerulonephritis With Dupilumab Treatment
- DOI:
10.1016/j.ekir.2024.09.024 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:
- 作者:
Mark H. Kaplan;Jessica M. Greco;Brad H. Rovin;Anthony M. Cannon;Abigail Pajulas;Jeffrey B. Travers;Ayman Hallab;Matthew J. Turner - 通讯作者:
Matthew J. Turner
Toxic cutaneous responses from inhalant abuse
- DOI:
10.1016/j.jdcr.2018.10.009 - 发表时间:
2019-01-01 - 期刊:
- 影响因子:
- 作者:
Ahmed Hawash;Jeffrey B. Travers;Sibel Gokce - 通讯作者:
Sibel Gokce
Lymphocyte activation in the pathogenesis of psoriasis.
银屑病发病机制中的淋巴细胞活化。
- DOI:
- 发表时间:
1997 - 期刊:
- 影响因子:6.5
- 作者:
David A. Norris;Jeffrey B. Travers;Donald Y.M. Leung - 通讯作者:
Donald Y.M. Leung
Jeffrey B. Travers的其他文献
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{{ truncateString('Jeffrey B. Travers', 18)}}的其他基金
Validation of Mesoscopic Imaging to Predict Cutaneous Carcinogenesis and its Therapeutic Response
验证细观成像预测皮肤癌发生及其治疗反应
- 批准号:
10295161 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Validation of Mesoscopic Imaging to Predict Cutaneous Carcinogenesis and its Therapeutic Response
验证细观成像预测皮肤癌发生及其治疗反应
- 批准号:
10041690 - 财政年份:2019
- 资助金额:
-- - 项目类别:
IGF-1 and the initiation of non-melanoma skin cancer
IGF-1 与非黑色素瘤皮肤癌的发生
- 批准号:
8967172 - 财政年份:2014
- 资助金额:
-- - 项目类别:
IGF-1 and the initiation of non-melanoma skin cancer
IGF-1 与非黑色素瘤皮肤癌的发生
- 批准号:
8539867 - 财政年份:2014
- 资助金额:
-- - 项目类别:
IGF-1 and the initiation of non-melanoma skin cancer
IGF-1 与非黑色素瘤皮肤癌的发生
- 批准号:
8892803 - 财政年份:2014
- 资助金额:
-- - 项目类别:
IGF-1 and the initiation of non-melanoma skin cancer
IGF-1 与非黑色素瘤皮肤癌的发生
- 批准号:
9242476 - 财政年份:2014
- 资助金额:
-- - 项目类别:
The Indiana Cutaneous Biological Research Training Program
印第安纳州皮肤生物学研究培训计划
- 批准号:
8473519 - 财政年份:2013
- 资助金额:
-- - 项目类别:
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