Oxidized lipids and UV immunosuppression
氧化脂质和紫外线免疫抑制
基本信息
- 批准号:8762399
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-10-01 至 2015-09-30
- 项目状态:已结题
- 来源:
- 关键词:Actinic keratosisAgonistAnti-Inflammatory AgentsAnti-inflammatoryAntioxidantsCancerousCellsChronicClinicalComplexContact hypersensitivityDiseaseEicosanoidsEnvironmental Risk FactorEnzymesExposure toFree RadicalsGoalsHealthcareHistamineHumanImmunosuppressionImmunosuppressive AgentsIn VitroInflammatoryInterleukin-10LaboratoriesLigandsLipidsMass Spectrum AnalysisMediatingMediator of activation proteinModelingMorbidity - disease rateMusMutagensNeoplasmsPathway interactionsPhototherapyPlatelet Activating FactorPlayProcessProductionPropertyRadiationRadiation therapyReactive Oxygen SpeciesRegulatory T-LymphocyteResearchResourcesRoleSkinSkin CancerSkin CarcinomaStimulusSun ExposureSunlightTestingTherapeutic EffectTransplantationUltraviolet B RadiationVeteranscell typecyclooxygenase 2cytokinedesignin vivoinsightkeratinocytemast cellmortalityneoplasticnoveloxidationoxidized lipidplatelet activating factor receptorresearch studyresponseskin disorderstressortoolultraviolet
项目摘要
DESCRIPTION (provided by applicant):
PROJECT SUMMARY: The primary goal of our research is to mechanistically characterize systemic immunosuppression induced by ultraviolet B radiation (UVB). The immunosuppressive effects of UVB are involved in the ability of this environmental stimulus to induce skin cancers. Moreover, UVB radiation treatments are used clinically to treat inflammatory skin disorders, in great part to its immunosuppressive effects. The planned research plans to take advantage of results of previous studies both in our laboratory and others indicating that UVB-mediated systemic immunosuppression involves novel glycerophosphocholine-derived lipids produced by epidermal cells in response to UVB. These compounds, some of which have not been structurally characterized, act as agonists for the Platelet-activating Factor (PAF) receptor. Accumulating evidence suggests that these PAF-R agonists exert immunosuppressive effects via a complex interplay of cell types and cytokines including mast cells, cyclooxygenase-2-produced eicosanoids, interleukin-10 and histamine. Two specific aims are planned to mechanistically characterize the complex pathway of UVB-mediated systemic immunosuppression using a well-established murine model of contact hypersensitivity. The first aim will use mass spectrometry to structurally characterize and quantitate PAF-R agonists produced by UVB in murine skin. The amounts of these novel PAF-R ligands produced enzymatically as well as through non- enzymatic free radical-mediated oxidation of glycerophosphosphocholines will be assessed using a mouse defective in PAF enzymatic synthesis and use of systemic antioxidants. The second aim will characterize the roles of mast cells and regulatory T cells using novel murine transplantation studies. Completion of the planned studies to characterize the cell types and mediators involved in UVB-mediated systemic immunosuppression should result in an enhanced understanding of this important process intimately involved in skin cancer.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey B. Travers其他文献
Relevance of the Platelet-activating factor system in chemical warfare agents-induced effects
血小板活化因子系统在化学战剂诱导效应中的相关性
- DOI:
10.1016/j.freeradbiomed.2024.12.037 - 发表时间:
2025-02-16 - 期刊:
- 影响因子:8.200
- 作者:
Anita Thyagarajan;Jeffrey B. Travers;Ravi P. Sahu - 通讯作者:
Ravi P. Sahu
Topical Photodynamic Therapy Generates Bioactive Microvesicle Particles: Evidence for a Pathway Involved in Immunosuppressive Effects
局部光动力疗法产生生物活性微泡颗粒:参与免疫抑制作用途径的证据
- DOI:
10.1016/j.jid.2022.12.018 - 发表时间:
2023-07-01 - 期刊:
- 影响因子:5.700
- 作者:
Oladayo A. Oyebanji;Chad Brewer;Sharlo Bayless;Benjamin Schmeusser;Danielle A. Corbin;Courtney E.W. Sulentic;Catherine M.T. Sherwin;Yanfang Chen;Christine M. Rapp;Elizabeth E. Cates;Yuhan Long;Jeffrey B. Travers;Craig A. Rohan - 通讯作者:
Craig A. Rohan
Case Studies of Sustained Remission of Membranous Glomerulonephritis With Dupilumab Treatment
- DOI:
10.1016/j.ekir.2024.09.024 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:
- 作者:
Mark H. Kaplan;Jessica M. Greco;Brad H. Rovin;Anthony M. Cannon;Abigail Pajulas;Jeffrey B. Travers;Ayman Hallab;Matthew J. Turner - 通讯作者:
Matthew J. Turner
Toxic cutaneous responses from inhalant abuse
- DOI:
10.1016/j.jdcr.2018.10.009 - 发表时间:
2019-01-01 - 期刊:
- 影响因子:
- 作者:
Ahmed Hawash;Jeffrey B. Travers;Sibel Gokce - 通讯作者:
Sibel Gokce
Lymphocyte activation in the pathogenesis of psoriasis.
银屑病发病机制中的淋巴细胞活化。
- DOI:
- 发表时间:
1997 - 期刊:
- 影响因子:6.5
- 作者:
David A. Norris;Jeffrey B. Travers;Donald Y.M. Leung - 通讯作者:
Donald Y.M. Leung
Jeffrey B. Travers的其他文献
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{{ truncateString('Jeffrey B. Travers', 18)}}的其他基金
Validation of Mesoscopic Imaging to Predict Cutaneous Carcinogenesis and its Therapeutic Response
验证细观成像预测皮肤癌发生及其治疗反应
- 批准号:
10595503 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Validation of Mesoscopic Imaging to Predict Cutaneous Carcinogenesis and its Therapeutic Response
验证细观成像预测皮肤癌发生及其治疗反应
- 批准号:
10295161 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Validation of Mesoscopic Imaging to Predict Cutaneous Carcinogenesis and its Therapeutic Response
验证细观成像预测皮肤癌发生及其治疗反应
- 批准号:
10041690 - 财政年份:2019
- 资助金额:
-- - 项目类别:
IGF-1 and the initiation of non-melanoma skin cancer
IGF-1 与非黑色素瘤皮肤癌的发生
- 批准号:
8967172 - 财政年份:2014
- 资助金额:
-- - 项目类别:
IGF-1 and the initiation of non-melanoma skin cancer
IGF-1 与非黑色素瘤皮肤癌的发生
- 批准号:
8539867 - 财政年份:2014
- 资助金额:
-- - 项目类别:
IGF-1 and the initiation of non-melanoma skin cancer
IGF-1 与非黑色素瘤皮肤癌的发生
- 批准号:
8892803 - 财政年份:2014
- 资助金额:
-- - 项目类别:
IGF-1 and the initiation of non-melanoma skin cancer
IGF-1 与非黑色素瘤皮肤癌的发生
- 批准号:
9242476 - 财政年份:2014
- 资助金额:
-- - 项目类别:
The Indiana Cutaneous Biological Research Training Program
印第安纳州皮肤生物学研究培训计划
- 批准号:
8473519 - 财政年份:2013
- 资助金额:
-- - 项目类别:
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