CSR&D Research Career Scientist Award Application
企业社会责任
基本信息
- 批准号:10595506
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-10-01 至 2024-09-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffectAmericanAnimalsAnxietyAreaAutomobile DrivingAutopsyAwardBig DataBiologicalBiological AssayBiological MarkersBlindnessBlood - brain barrier anatomyBrainBrain regionCause of DeathCerebellumCessation of lifeChildhoodChronicChronic stressClinicalClinical ResearchCognitive deficitsCollaborationsComplexComputer ModelsComputing MethodologiesCuesDNA MethylationDNA analysisDNA mappingDNA methylation profilingDataDepartment of DefenseDevelopmentDiseaseDoctor&aposs DegreeEnvironmentEnvironmental ExposureEnvironmental Risk FactorEpigenetic ProcessEtiologyExhibitsExposure toFundingGene ExpressionGenerationsGenesGeneticGenetic DiseasesGenetic TranscriptionGenetic studyGenomeGenomic approachGenomicsHealth systemHealthcareHumanImmunityIncidenceIndividualInflammatoryInjuryInvestigationJournalsLaboratoriesLarge-Scale SequencingLeadershipLongevityMacular degenerationMedicalMedical centerMental DepressionMental disordersMethodsMethylationMilitary PersonnelMolecularMolecular ProfilingNatureNeocortexNeuronsPhysician ExecutivesPost-Traumatic Stress DisordersPrefrontal CortexProductivityProteomicsPsychiatric therapeutic procedurePsychosocial StressPublicationsPublishingResearchResearch PersonnelRisk FactorsRodentRoleSamplingScienceScientistSeminalSignal TransductionSleep disturbancesStargardt&aposs diseaseStatistical ModelsStressSuicideSymptomsTechnologyTissuesTraumatic Brain InjuryUnited StatesUnited States National Institutes of HealthUniversitiesVeteransWorkblast exposurecareercombatearly onsetepigenomegene environment interactiongenome-wideinsightinterestmachine learning algorithmmammalian genomemedical specialtiesmethylation patternmild traumatic brain injurymilitary veteranneocorticalneuroinflammationneuropathologyneuropsychiatric disorderprogramspsychiatric symptompsychosocial stressorsresponsestemstressorsuccesssuicidalsuicidal behaviorsuicidal risksuicide brainsuicide victimtranscriptome sequencingtranscriptomicswhole genome
项目摘要
SUMMARY
Dr. Haghighi's research specialty is in medical epigenetics with applications to traumatic brain Injury (TBI),
depression, and suicidal behavior. These epigenetic studies involve how genes are differentially transcribed
and regulated, within human clinical and postmortem brain samples, providing a snapshot of potential
transcriptional regulatory abnormalities associated with disease neuropathology. Dr. Haghighi's clinical studies
show how environmental exposure affects the epigenome. Specifically, in her studies involving traumatic brain
injury, she investigates how response to repeated blast-exposure induces long-term transcriptional regulatory
changes resulting in symptoms of sleep disturbances, anxiety, cognitive deficits and depression and PTSD.
Additionally, she investigates how the role of stress, specifically chronic stress, induces epigenetic changes
associated with depression and suicide in the Veteran population.
摘要
HagHighi博士的研究专长是医学表观遗传学及其在创伤性脑损伤(TBI)中的应用,
抑郁和自杀行为。这些表观遗传学研究涉及基因是如何差异转录的
并在人类临床和死后大脑样本中进行调控,提供了潜在的快照
与疾病神经病理学相关的转录调控异常。HagHighi博士的临床研究
展示环境暴露如何影响表观基因组。具体地说,在她关于创伤脑的研究中
,她研究了对反复爆炸暴露的反应如何诱导长期转录调控
导致睡眠障碍、焦虑、认知缺陷、抑郁和创伤后应激障碍等症状的变化。
此外,她还研究了压力,特别是慢性压力是如何引起表观遗传变化的。
与退伍军人中的抑郁和自杀有关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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FATEMEH G HAGHIGHI其他文献
FATEMEH G HAGHIGHI的其他文献
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{{ truncateString('FATEMEH G HAGHIGHI', 18)}}的其他基金
Identifying DNA Methylation Alterations of Chronic Effects Of Blast and Disturbed Sleep
识别爆炸和睡眠不安的慢性影响的 DNA 甲基化改变
- 批准号:
10425829 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Identifying DNA Methylation Alterations of Chronic Effects Of Blast and Disturbed Sleep
识别爆炸和睡眠不安的慢性影响的 DNA 甲基化改变
- 批准号:
10609849 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Identifying Bio-signatures of Suicidal Subtypes in Veterans
识别退伍军人自杀亚型的生物特征
- 批准号:
10683055 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Identifying Bio-signatures of Suicidal Subtypes in Veterans
识别退伍军人自杀亚型的生物特征
- 批准号:
10225980 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Identifying Bio-signatures of Suicidal Subtypes in Veterans
识别退伍军人自杀亚型的生物特征
- 批准号:
9925062 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Identifying Bio-signatures of Suicidal Subtypes in Veterans
识别退伍军人自杀亚型的生物特征
- 批准号:
10704723 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Neuroinflammatory and Epigenetic Mechanisms of Blood-Brain Barrier Compromise in Suicide
自杀中血脑屏障受损的神经炎症和表观遗传机制
- 批准号:
10427188 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Neuroinflammatory and Epigenetic Mechanisms of Blood-Brain Barrier Compromise in Suicide
自杀中血脑屏障受损的神经炎症和表观遗传机制
- 批准号:
10554314 - 财政年份:2018
- 资助金额:
-- - 项目类别:
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