CSR&D Research Career Scientist Award Application

总结 博士Haghighi的研究专长是医学表观遗传学，应用于创伤性脑损伤（TBI）， 抑郁和自杀行为这些表观遗传学研究涉及基因是如何差异转录的 在人类临床和死后的大脑样本中， 与疾病神经病理学相关的转录调节异常。Haghighi医生的临床研究 展示环境暴露如何影响表观基因组。具体来说，在她的研究中， 损伤，她研究了如何响应重复爆炸暴露诱导长期转录调控 导致睡眠障碍、焦虑、认知缺陷和抑郁症以及创伤后应激障碍症状的变化。 此外，她还研究了压力的作用，特别是慢性压力，如何诱导表观遗传变化 与退伍军人抑郁症和自杀有关

SUMMARY Dr. Haghighi's research specialty is in medical epigenetics with applications to traumatic brain Injury (TBI), depression, and suicidal behavior. These epigenetic studies involve how genes are differentially transcribed and regulated, within human clinical and postmortem brain samples, providing a snapshot of potential transcriptional regulatory abnormalities associated with disease neuropathology. Dr. Haghighi's clinical studies show how environmental exposure affects the epigenome. Specifically, in her studies involving traumatic brain injury, she investigates how response to repeated blast-exposure induces long-term transcriptional regulatory changes resulting in symptoms of sleep disturbances, anxiety, cognitive deficits and depression and PTSD. Additionally, she investigates how the role of stress, specifically chronic stress, induces epigenetic changes associated with depression and suicide in the Veteran population.