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CSR&D Research Career Scientist Award Application

企业社会责任

基本信息

批准号：
10295170
负责人：
FATEMEH G HAGHIGHI
金额：
--
依托单位：
JAMES J PETERS VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-10-01 至 2024-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10295170
关键词：
Acute Affect American Animals Anxiety Area Automobile Driving Autopsy Award Big Data Biological Biological Assay Biological Markers Blindness Blood - brain barrier anatomy Brain Brain region Cause of Death Cerebellum Cessation of life Childhood Chronic Chronic stress Clinical Clinical Research Cognitive deficits Collaborations Complex Computer Models Computing Methodologies Cues DNA Methylation DNA analysis DNA mapping DNA methylation profiling Data Department of Defense Depression and Suicide Development Disease Doctor&apos s Degree Environment Environmental Exposure Environmental Risk Factor Epigenetic Process Etiology Exhibits Exposure to Foundations Funding Gene Expression Generations Genes Genetic Genetic Diseases Genetic Transcription Genetic study Genome Genomic approach Genomics Health system Healthcare Human Immunity Incidence Individual Inflammatory Injury Investigation Journals Laboratories Large-Scale Sequencing Lead Leadership Longevity Macular degeneration Medical Medical center Mental Depression Mental disorders Methods Methylation Military Personnel Molecular Molecular Profiling Nature Neocortex Neurons Physician Executives Post-Traumatic Stress Disorders Prefrontal Cortex Proteomics Psychiatric therapeutic procedure Psychosocial Stress Publications Publishing Research Research Personnel Risk Factors Rodent Role Sampling Science Scientist Seminal Signal Transduction Sleep disturbances Stargardt&apos s disease Statistical Models Stress Suicide Symptoms Technology Tissues Traumatic Brain Injury United States United States National Institutes of Health Universities Veterans Work base blast exposure career combat early onset epigenome gene environment interaction genome-wide insight interest machine learning algorithm mammalian genome medical specialties methylation pattern mild traumatic brain injury military veteran neuroinflammation neuropathology neuropsychiatric disorder programs psychiatric symptom psychosocial stressors response stem stressor success suicidal suicidal behavior suicidal risk suicide brain suicide victim transcriptome sequencing transcriptomics whole genome

项目摘要

SUMMARY Dr. Haghighi's research specialty is in medical epigenetics with applications to traumatic brain Injury (TBI), depression, and suicidal behavior. These epigenetic studies involve how genes are differentially transcribed and regulated, within human clinical and postmortem brain samples, providing a snapshot of potential transcriptional regulatory abnormalities associated with disease neuropathology. Dr. Haghighi's clinical studies show how environmental exposure affects the epigenome. Specifically, in her studies involving traumatic brain injury, she investigates how response to repeated blast-exposure induces long-term transcriptional regulatory changes resulting in symptoms of sleep disturbances, anxiety, cognitive deficits and depression and PTSD. Additionally, she investigates how the role of stress, specifically chronic stress, induces epigenetic changes associated with depression and suicide in the Veteran population.

概括 Haghighi 博士的研究专业是医学表观遗传学及其在创伤性脑损伤 (TBI) 中的应用，抑郁症和自杀行为。这些表观遗传学研究涉及基因如何差异转录并在人类临床和死后大脑样本中进行监管，提供潜在的快照与疾病神经病理学相关的转录调控异常。 Haghighi 博士的临床研究显示环境暴露如何影响表观基因组。具体来说，在她涉及脑外伤的研究中受伤后，她研究了对重复爆炸暴露的反应如何诱导长期转录调节导致睡眠障碍、焦虑、认知缺陷、抑郁和创伤后应激障碍（PTSD）症状的变化。此外，她还研究了压力（特别是慢性压力）的作用如何引起表观遗传变化与退伍军人群体的抑郁和自杀有关。