Neurobiological Mechanisms Linking Acute Alcohol Intoxication to Impulsivity and Cigarette Craving in Nondaily Smokers

项目摘要 本研究的目的是探讨急性酒精中毒的神经生物学机制 非每日吸烟的年轻人（21-25岁）吸烟中毒。非日常吸烟者的经验较少 吸烟者的戒烟症状比日常吸烟者更明显;然而，他们仍然难以戒烟。以来 在30岁之前戒烟可以大大减轻长期健康后果 与吸烟相关，了解促使年轻非日常吸烟者吸烟的因素， 制定有针对性的干预措施对于遏制吸烟和改善公共卫生至关重要。的 一个提议的项目将使用功能性磁共振成像（fMRI）来研究急性酒精中毒 中毒影响大脑功能，并将评估酒精引起的大脑变化的程度 功能与冲动选择、烟瘾和烟瘾调节相关。此外，委员会认为， 我们将评估酒精如何引起大脑功能、冲动、渴望和渴望能力的变化， 该法规预测了一年内的香烟使用量。 这一K 01申请推进了PI的长期研究目标，即建立一个独立的生产线， 研究检查神经生物学标志物，赋予未来物质使用障碍的风险， 多模式神经成像技术。拟议的培训计划将使PI能够发展技能， 在五个主要领域的专业知识：1）纵向研究的设计和实施，2）基于任务和休息- 国家功能磁共振成像，3）先进的统计方法，4）评估急性神经生物学反应的药物 5）冲动选择的神经生物学基础。培训计划结合了正式的 在拟议培训领域的专家、经验丰富的顾问的指导下完成课程。 该项目将利用OHSU和内格尔博士的发展中心的智力和机构支持。 脑成像实验室，以开发一个新的研究线，将形成职业生涯的基础， 独立研究员。

PROJECT SUMMARY The purpose of this study is to investigate the neurobiological mechanisms that link acute alcohol intoxication with cigarette use in young nondaily smokers (ages 21-25). Nondaily smokers experience fewer symptoms of cigarette withdrawal than daily smokers; however, they still experience difficulty quitting. Since smoking cessation before the age of 30 substantially attenuates the long-term health consequences associated with smoking, understanding the factors that motivate cigarette use in young nondaily smokers and developing tailored interventions will be critical for curbing cigarette use and improving public health. The proposed project will use functional magnetic resonance imaging (fMRI) to examine how acute alcohol intoxication impacts brain function and will assess the extent to which alcohol-induced changes in brain function correlate with impulsive choice, cigarette craving, and craving regulation in young adults. Furthermore, we will assess how alcohol-induced changes in brain function, impulsivity, craving, and capacity for craving regulation predict cigarette use over the course of 1 year. This K01 application advances the PI's long-term research goal of establishing an independent line of research examining neurobiological markers that confer risk for future substance use disorder using multimodal neuroimaging techniques. The proposed training plan will enable the PI to develop skills and expertise in five primary areas: 1) design and implementation of longitudinal studies, 2) task-based and resting- state fMRI, 3) advanced statistical methods, 4) the assessment of acute neurobiological responses to drugs and 5) the neurobiological underpinnings of impulsive choice. The training program combines formal coursework with mentorship from experienced consultants who are experts in the proposed areas of training. This project will leverage the intellectual and institutional support at OHSU and in Dr. Nagel's Developmental Brain Imaging Laboratory in order to develop a new line of research that will form the foundation for a career as an independent researcher.