RADIATION INDUCED THYROID CANCER

这项研究计划的主要目的是研究辐射引起的 通过协调的临床和实验室研究发现了甲状腺癌。这个 临床研究旨在确定该病的持续发病率。 目的：探讨放射性甲状腺癌的诊断和治疗方法 内科和外科治疗方法。这将通过以下方式实现 继续儿童头部移植患者的纵向研究 在迈克尔里斯医院接受良性条件的颈部放射治疗。的 在接受这种治疗的5,300名患者中，有2,000名已经在我们的 该计划和另外1400个项目已经在其他地方进行了评估。在这 人口中甲状腺结节的累积患病率为36%， 在那些做过手术的人中，36%的人患有甲状腺癌。以下是- 这一人口的增加将继续实现以下目标：(1) 确定辐射诱发的甲状腺癌是否仍在继续发生， 若有，请提供有关发病率的估计数字；。(2)由于 这些人口正在变老，以确定他们的辐射诱导 甲状腺癌具有与年龄相关的恶化预后，如 普通人群，以及(3)评估已有的治疗方法 已经被利用了。综合起来，这些将提供开发所需的信息 有辐射病史的人的护理指南。我们的 对其他辐射诱导的肿瘤的平行研究将继续进行 已发现，包括唾液、神经和甲状旁腺起源的。 特定器官剂量，而不是治疗剂量，将被确定为 获得更准确的剂量-反应曲线和风险评估。研究到 确定是否有发病的易感因素 与辐射有关的肿瘤，特别是家族性肿瘤，将扩大范围。 实验室研究将集中在血清甲状腺球蛋白在 甲状腺肿瘤的诊断。一组患者的临床表现 包括甲状腺扫描在内的评估都是正常的，但谁升高了 已确定血清甲状腺球蛋白水平。在继续进行以下工作时- 在这些患者和对照组患者中，我们将确定 异常测定作为危险因素的意义。以下内容如下： UP还将提供将扫描与超声波进行比较的机会 甲状腺检查甲状腺的检查造成非均质性的因素 与甲状腺肿瘤有关的甲状腺球蛋白分子将是 学习。

The major objective of this research proposal is to study radiation-induced thyroid cancer by coordinated clinical and laboratory investigations. The clinical studies are designed to determine the continuing incidence of radiation-induced thyroid cancer and to evaluate methods of diagnosis and medical and surgical approaches to treatment. This will be accomplished by continuing the longitudinal study of patients who received childhood head and neck irradiation for benign conditions at Michael Reese Hospital. Of the 5,300 patients who were so treated, 2,000 have been examined in our program and another 1,400 have been evaluated elsewhere. In this population there is a 36% cumulative prevalence of thyroid nodules and among those who have had surgery, 36% have had thyroid cancer. The follow- up of this population will continue with the following aims: (1) to determine if radiation-induced thyroid cancer is continuing to occur and, if so, to provide an estimate of its incidence, (2) since the patients in this population are growing older, to determine if their radiation-induced thyroid cancers have the same age-dependent worsening prognosis as seen in the general population, and (3) to evaluate the treatment methods that have been used. Together these will provide the information to develop guidelines for the care of persons with a history of radiation. Our parallel studies will continue on other radiation-induced tumors which have been found, including those of salivary, neural, and parathyroid origin. Specific organ doses, as opposed to treatment doses, will be determined to obtain more precise dose-response curves and risk assessments. Studies to determine whether there are susceptibility factors for developing radiation-related neoplasms, especially familial ones, will be extended. Laboratory studies will focus on the role of serum thyroglobulin in the diagnosis of thyroid tumors. A subgroup of patients whose clinical evaluations, including thyroid scans, were normal, bur who had elevated serum thyroglobulin levels has been identified. In continuing the follow- up of these patients and a control group of patients we will determine the significance of the abnormal determination as a risk factor. This follow- up will also provide an opportunity to compare scans with ultrasound examinations of the thyroid. Factors contributing to the heterogeneity of the thyroglobulin molecule, with relation to thyroid neoplasms, will be studied.