RADIATION INDUCED THYROID CANCER

这项研究计划的主要目的是研究辐射引起的 通过协调的临床和实验室研究发现了甲状腺癌。这个 临床研究旨在确定该病的持续发病率。 目的：探讨放射性甲状腺癌的诊断和治疗方法 内科和外科治疗方法。这将通过以下方式实现 继续对接受过评估的患者进行纵向研究 Michael Reese医院因儿童期头颈部病史 辐射。在接受过这种治疗的5300名患者中，有1900名患者得到了 已经检查并联系了另外1,600人。在这里的人口中 结节的患病率为37%，而接受过手术的人中结节患病率为35% 曾患过甲状腺癌。后续行动将继续提供估计 辐射导致的甲状腺癌的发病率，现在估计至少 每年有1.5%的人口处于危险之中。对患者进行的随访 结核将提供对已采取的处理方法的评价 使用。综合起来，这些将为制定指导方针提供信息 用于护理有辐射病史的人。类似的研究 将继续研究已发现的其他辐射诱导的肿瘤， 包括唾液、神经和甲状旁腺起源的肿瘤。 实验室研究将集中在血清甲状腺球蛋白在 甲状腺肿瘤的诊断。慢性阻塞性肺病患者血浆甲状腺球蛋白升高 大多数甲状腺结节患者和12%的甲状腺结节患者 有受过辐射的病史，但其他方面看起来完全正常。一个 最初升高的甲状腺球蛋白水平表明形成的风险更高。 甲状腺结节。在对患者进行跟踪期间，将有可能 确定血清甲状腺球蛋白的变化是否也有临床意义 在受辐射人群中的相关性。在甲状腺癌患者中 将获得连续的甲状腺球蛋白测定，以评估如何 这些测量方法应用于临床。影响经济增长的因素 对甲状腺球蛋白放射免疫测定法进行了研究。

The major objective of this research proposal is to study radiation-induced thyroid cancer by coordinated clinical and laboratory investigations. The clinical studies are designed to determine the continuing incidence of radiation-induced thyroid cancer and to evaluate methods of diagnosis and medical and surgical approach to treatment. This will be accomplished by continuing the longitudinal study of patients who have been evaluated at Michael Reese Hospital because of a history of childhood head and neck irradiation. Of 5,300 patients who were so treated, 1,900 have been examined and another 1,600 have been contacted. In this population there is a 37% prevalence of nodules and among those who have had surgery 35% have had thyroid cancer. Follow-up will continue to provide an estimate of the incidence of radiation-induced thyroid cancer, now estimated at least 1.5% of the population at risk per year. Follow-up of patients who had nodules will provide an evaluation of the treatment methods which have been used. Together these will provide the information to develop guidelines for the care of persons with a history of irradiation. Similar studies will continue on the other radiation-induced tumors which have been found, including those of salivary, neural, and parathyroid origin. Laboratory studies will focus on the role of serum thyroglobulin in the diagnosis of thyroid tumors. Plasma thyroglobulin is elevated in a majority of patients with thyroid nodules and in 12% of patients with a history of irradiation but who otherwise appear completely normal. An initially elevated thyroglobulin level indicates a higher risk of forming thyroid nodules. While patients are being followed, it will be possible to determine whether changes in serum thyroglobulin also have clinical relevance in an irradiated population. In patients with thyroid cancer sequential thyroglobulin determinations will be obtained to assess how these measurements should be used clinically. Factors influencing the radioimmunoassay determination of thyroglobulin will be studied.