RADIATION INDUCED THYROID CANCER

这项研究计划的主要目标是研究辐射-- 临床、流行病学和免疫系统协同作用诱发甲状腺癌 实验室调查。这些临床研究旨在 确定辐射所致甲状腺癌的持续发病率 并评估诊断方法以及内科和外科方法 去接受治疗。这将通过继续纵向 儿童头颈部放射治疗的临床研究 迈克尔·里斯医院情况良好。在4296名患者中 已找到3058人(71.2%)和1025人(33.5 %)做过甲状腺结节手术。在那些有过 手术中，357人(34.8%)患过甲状腺癌。的后续行动 这一群体将继续实现以下目标：(1)确定 辐射诱发的甲状腺癌的持续发病率，(2)至 确定他们的辐射诱发的甲状腺癌是否有相同的年龄- 在一般人群中可见的依赖恶化的预后，以及(3) 评估已有的诊断方法和治疗方法 使用。实验室研究将集中在血清甲状腺球蛋白的作用上。 在甲状腺肿瘤的诊断中。平行研究将继续进行 其他辐射诱发的肿瘤，包括良性和恶性唾液腺 肿瘤、神经肿瘤、甲状旁腺肿瘤等。把这些放在一起 将提供信息以制定护理指南 有辐射史的人。流行病学研究将集中在 关于鉴定可遗传辐射存在的证据 易感因素。照射后多发肿瘤的形态特征 研究人员将分析癌症的个人和家族病史。标本 以前手术中的肿瘤将被用来研究特定的 癌基因作为辐射诱导的标志物和参与者 肿瘤性转化。这些研究将集中在重新安排上。 原癌基因ret在甲状腺肿瘤和NF2肿瘤中的表达 神经肿瘤中的抑癌基因。

The major objective of this research proposal is to study radiation- induced thyroid cancer by coordinated clinical, epidemiological and laboratory investigations. The clinical studies are designed to determine the continuing incidence of radiation-induced thyroid cancer and to evaluate methods of diagnosis and medical and surgical approaches to treatment. This will be accomplished by continuing the longitudinal study of patients who received childhood head and neck irradiation for benign conditions at Michael Reese Hospital. Of the 4,296 patients who were so treated 3,058 (71.2 percent) have been located and 1,025 (33.5 percent) have had surgery for thyroid nodules. Among those who have had surgery, 357 (34.8 percent) have had thyroid cancer. The follow-up of this population will continue with the following aims: (1) to determine the continuing incidence of radiation-induced thyroid cancer, (2) to determine if their radiation-induced thyroid cancers have the same age- dependent worsening prognosis as seen in the general population, and (3) to evaluate the diagnostic methods and treatment methods that have been used. Laboratory studies will focus on the role of serum thyroglobulin in the diagnosis of thyroid tumors. Parallel studies will continue on other radiation-induced tumors, including benign and malignant salivary tumors, neural tumors, parathyroid tumors and others. Together these will provide the information to develop guidelines for the care of persons with a history of radiation. Epidemiological studies will focus on identifying evidence for the existence of heritable radiation susceptibility factors. Patterns of multiple tumors in irradiated individuals and family histories of cancer will be analyzed. Specimens of neoplasms from previous surgery will be used to study specific oncogenes as markers of and as participants in radiation-induced neoplastic transformation. These studies will focus on rearrangements of the ret protooncogene in thyroid neoplasms and the NF2 tumor suppressor gene in neural tumors.