Developing a Quorum Sensing system into an efficient and economical way to control industrial production of high value products

将群体感应系统开发为一种高效且经济的方式来控制高价值产品的工业生产

• 批准号: 102300
• 金额: $ 69.28万
• 依托单位: SMITHKLINE BEECHAM LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=102300
• 关键词: Developing; Quorum; Sensing; system; into

Natural or engineered biosynthesis can replace chemical synthesis with more environmentally friendly, sustainable bio-manufacturing processes to generate small molecule products such as pharmaceuticals. Although expression systems for recombinant proteins have been developed for laboratory scale and for commercial expression of very high value products such as antibodies, these are often unsuitable for industrial manufacture at scale and rarely appropriate for construction of recombinant biosynthetic pathways. The most significant gap is in mechanisms for control of gene expression, essential to turn a laboratory concept into a working, scalable bioprocess. Natural cellular systems have very sophisticated control mechanisms, one of which we propose to exploit as an induction free, highly efficient system for industry, equally capable of expressing single enzymes or large metabolic pathways.

自然或工程生物合成可以用更环保、可持续的生物制造工艺取代化学合成，以生产小分子产品，如药品。虽然重组蛋白的表达系统已经被开发用于实验室规模和高价值产品（如抗体）的商业表达，但这些系统通常不适合大规模的工业生产，也很少适合重组生物合成途径的构建。最重要的差距是基因表达的控制机制，这对于将实验室概念转化为有效的、可扩展的生物过程至关重要。自然细胞系统具有非常复杂的控制机制，我们建议利用其中一个作为无诱导，高效的工业系统，同样能够表达单一酶或大型代谢途径。