Understanding platinum dissolution in biomedical stimulating electrodes

了解生物医学刺激电极中铂的溶解

• 批准号: LP190101139
• 负责人: Prof Laura Poole-Warren
• 金额: $ 50.9万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-11-16 至 2025-11-17
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP190101139
• 关键词: Understanding; platinum; dissolution; biomedical; stimulating

Platinum is the main material used in electrodes for neurostimulators like the cochlear implant. Platinum electrodes can experience dissolution during implantation, which can impact on their function. The mechanisms governing this dissolution process are complex and still not fully understood. This research aims to understand the chemical, electrical and biological factors that impact on platinum dissolution in electrodes. It will also develop new 3D models to simulate conditions in the human body for more rapid testing of electrodes. The new knowledge generated will improve the accuracy of predictions of platinum dissolution, develop new approaches for minimising dissolution, and contribute to reducing need for animal experimentation.

铂是用于神经刺激器（如耳蜗植入物）电极的主要材料。铂电极在植入过程中可能会溶解，这可能会影响其功能。控制这种溶解过程的机制是复杂的，仍然没有完全理解。本研究旨在了解影响电极中铂溶解的化学，电学和生物学因素。它还将开发新的3D模型来模拟人体条件，以便更快速地测试电极。所产生的新知识将提高铂溶解预测的准确性，开发最小化溶解的新方法，并有助于减少对动物实验的需求。