Design and characterisation of a polysaccharide-based biomaterial for tissue adhesion

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This proposal aims to design a new bio-adhesive material and study the mechanisms of action for tissue adhesion. Current suture technology is inadequate for anything but simple repairs and the alternative offered by surgical glues available today is at most augmentation of suturing. Combination of a strong adhesive biomaterial with factors for accelerating wound healing will generate a novel material technology that, by uniting wound closure with sealing, addresses an unmet need in surgery. The primary outcomes of these investigations will be: 1. advancement of knowledge in theories of tissue-biomaterial adhesion mechanisms 2. knowledge of effects of visible light from laser diodes on cells and isolated tissue 3. a biocompatible, visible light activated adhesive film for tissue repair based on chitosan polysaccharides