Skin safety testing to enable far-UV-C technologies for wide-spread inactivation of SARS-CoV-2

皮肤安全测试使远 UV-C 技术能够广泛灭活 SARS-CoV-2

• 批准号: 103581
• 金额: $ 22.36万
• 依托单位: TEN BIO LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=103581
• 关键词: Skin; safety; testing; enable; far

UV light is known to inactivate SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It is also widely claimed that high energy UV light, called "far-UV-C", is 'safe for humans', although this claim is based predominantly on animal studies and limited studies in human volunteers. The UK is expected to begin employing far-UV-C in public spaces in 2021\. It is proposed here to _rapidly_ generate safety data showing whether or not far-UV-C causes the types of damage that full-spectrum UV light does (for example, sunburn, DNA damage, immunosuppression of the skin, and modifications to the skin microbiome, which is the natural flora that lives in healthy human skin). It is imperative that we understand the effects of far-UV-C on human skin to ensure it can be deployed to its full effectWe are proposing here to conduct the following far-UV-C research projects to investigate the efficacy and safety profile of this very promising technology:* DNA damage upon acute and chronic far-UV-C exposure* DNA damage to compromised skin (for example, wounded skin) upon far-UV-C exposure* Response of immune cells resident in the skin to far-UV-C (it is known that UV-B light elicits an immune response in skin, but the effect of far-UV-C has not been evaluated)* Evaluation of skin microbiome following acute and chronic exposure to far-UV-C. Far-UV-C irradiation may kill or modify the genetic material of the beneficial flora that colonise the skin by the same mechanism by which SARS-CoV-2 is inactivated* Computer simulation of far-UV-C penetration into skin guided by the data generated in the skin modelWe propose to conduct these experiments in our novel patent-protected _ex vivo_ skin model (TenSkin(tm)) which is the closest mimic available to human skin while still on the body.

已知紫外线可杀灭导致COVID-19大流行的SARS-CoV-2病毒。人们还普遍声称，高能紫外线，称为“远紫外线-C”，是“对人类安全”，尽管这种说法主要是基于动物研究和人类志愿者的有限研究。英国预计将于2021年开始在公共场所使用远紫外线-C。本文建议快速生成安全数据，显示远紫外线-C是否会引起全光谱紫外线造成的损伤类型（例如，晒伤、DNA损伤、皮肤免疫抑制和皮肤微生物组的改变，皮肤微生物组是健康人体皮肤中的天然植物群）。我们必须了解远紫外线-C对人体皮肤的影响，以确保它可以充分发挥其作用。我们在这里建议进行以下远紫外线-C研究项目，以调查这种非常有前途的技术的有效性和安全性：* 急性和慢性远紫外线-C暴露后的DNA损伤 * 受损皮肤的DNA损伤（例如，受伤的皮肤）对远紫外线-C暴露的反应 *（已知UV-B光激发皮肤中的免疫应答，但远UV-C的作用尚未评估）* 评估急性和慢性暴露于远UV-C后的皮肤微生物组。远紫外线-C辐射可能会杀死或改变有益的植物群的遗传物质，这些植物群通过与SARS-CoV-2灭活相同的机制在皮肤模型中生成的数据指导下远紫外线-C渗透到皮肤中的计算机模拟我们建议在我们的新型专利保护的离体皮肤模型中进行这些实验。（TenSkin（TM）），其是仍在身体上时可获得的最接近人类皮肤的模拟物。