Enhancing Drug Solubility Using Novel Dry Powder Coating Technology

利用新型干粉包衣技术提高药物溶解度

• 批准号: 103781
• 金额: $ 8.91万
• 依托单位: ASTON PARTICLE TECHNOLOGIES LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=103781
• 关键词: Enhancing; Drug; Solubility; Using; Novel

There is a lack of available technologies for particle surface modification that do not affect the particles physical and chemical properties. Currently 70% of new drugs being developed exhibit poor solubility and this provides a huge challenge and high cost for drug development in the pharmaceutical market. Current techniques are expensive, produce low yield and cannot process unstable drugs. Aston Particle Technologies Ltd. "APT" offers a novel one-step particle engineering technology that processes drugs and materials without the use of solvents and heat. Its USP lies in delivering enhanced particle properties for challenging drugs (high dose, moisture sensitive or heat sensitive) at low cost. APTs solubility enhancement project aims to increase the solubility of poorly soluble drugs, including those that are unstable, through its particle layering technology.

目前缺乏不影响颗粒物理和化学性质的颗粒表面改性技术。目前70%正在开发的新药溶解度较差，这给医药市场的药物开发带来了巨大的挑战和高昂的成本。目前的技术价格昂贵，产量低，不能加工不稳定的药物。阿斯顿粒子技术有限公司“APT”提供了一种新的一步粒子工程技术，可以在不使用溶剂和热量的情况下处理药物和材料。其USP在于以低成本为具有挑战性的药物（高剂量，湿热敏感或热敏）提供增强的颗粒特性。APTs的溶解度增强项目旨在通过其颗粒分层技术提高难溶性药物（包括不稳定药物）的溶解度。