Newton Fund - Precision management (PM) of Epilepsy in South African children

牛顿基金会 - 南非儿童癫痫的精准管理 (PM)

• 批准号: 103992
• 金额: $ 25.61万
• 依托单位: APARITO LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=103992
• 关键词: Newton; Fund; Precision; management; PM

Epilepsy is one of the most common neurological disorders worldwide with over 500,000 suffers in South Africa (SA) alone. The prevalence of epilepsy in low to middle income countries is substantially greater than in more resourced countries - 81.7 compared with 45.0 per 100,000 and affects a younger population.Precision medicine aims to optimise therapeutic benefit to patients by understanding and responding to individual circumstances. To date, such approaches have been considered to be too expensive to roll out in emerging countries. There are no studies published on technology-based monitoring in epilepsy in Africa and very little on the genetic aetiology or pharmacogenetics of epilepsy particularly in Sub-Saharan Africa.mHealth provides the opportunity for interaction between patients, caregivers and health care professionals empower people to be partners in their or their children's health. It allows for active engagement and data that can be collated could contribute to better understanding and partnerships in a way that take public views into account. Medication adherence is a major reason for poor control in epilepsy and a challenge for caregiver's is remembering to give frequent medications that often change in dose and timing. An easy and reliable reminder is likely to improve adherence.The Aparito app allows for a visual representation of the health of affected individuals that can be shared with doctors by caregivers in real-time. The nature of the 2 way interaction could allow for health promotion messages to be shared with caregivers in their own time on a regular basis. Ill health carries a significant economic burden on families whose lives are already stressed by poverty and this initiative can allow for a better understanding of how the burden of care may be eased by allowing recording of daily realities in real time.Medical technologies have great potential but must be affordable, feasible and culturally acceptable. This study aims to interrogate the challenges and perspectives of South Africans on the use of such initiatives such as this so that implementation of any such initiative takes into account the community's view and needs.Remote monitoring and communication using cell phone technology allows for collaboration between different health care sectors and the families in an objective and reliable way if data on the affected child can be readily collated and is easily accessible to all involved in their care.This Newton Fund project is working towards the United Nations Sustainable Development Goals 3 - Good Health and Wellbeing; Ensuring healthy lives and promote well-being for all at all ages.

癫痫是世界上最常见的神经系统疾病之一，仅在南非（SA）就有超过50万人患有癫痫。低收入至中等收入国家的癫痫患病率显著高于资源丰富的国家--每10万人中有81.7人，而资源丰富的国家为45.0人，并且影响的人群更年轻。精准医疗旨在通过了解和应对个体情况，优化患者的治疗获益。迄今为止，这些方法被认为过于昂贵，无法在新兴国家推广。目前还没有发表关于非洲癫痫病基于技术的监测的研究，关于癫痫病遗传病因学或药物遗传学的研究也很少，特别是在撒哈拉以南非洲。移动健康为患者、护理人员和卫生保健专业人员之间的互动提供了机会，使人们能够成为自己或子女健康的伙伴。它允许积极参与，可以整理的数据可以以考虑公众意见的方式促进更好的理解和伙伴关系。药物依从性是癫痫控制不佳的主要原因，护理人员面临的挑战是记住经常给予剂量和时间经常变化的药物。一个简单可靠的提醒可能会提高依从性。Aparito应用程序允许受影响个体的健康状况的可视化表示，可以由护理人员实时与医生分享。双向交互的性质可以允许健康促进信息在护理人员自己的时间定期与他们分享。健康不佳给那些生活已经因贫困而不堪重负的家庭带来了沉重的经济负担，这一举措可以使人们更好地了解如何通过真实的记录日常现实来减轻护理负担，医疗技术具有巨大的潜力，但必须是负担得起的、可行的和文化上可接受的。这项研究旨在询问南非人在使用此类举措时面临的挑战和观点，以便任何此类举措的实施都考虑到社区的观点和需求。如果可以随时整理有关受影响儿童的数据，牛顿基金的这一项目致力于实现联合国可持续发展目标3 --良好的健康和福祉;确保健康的生活，促进所有年龄段的所有人的福祉。