Efficient phylogenetic methods that manage the curse of genomic complexity

该项目旨在开发新的方法和软件，利用基因组数据推断生物体的进化史。这些新的系统基因组学方法需要考虑到进化过程和/或模式在时间(沿着进化树)和空间(沿着基因组)上的复杂性。这个项目意义重大，因为这些方法必须将数学和统计学与高性能计算相结合，以处理海量的遗传数据和进化本身的复杂性。该项目的一个重要预期成果将是开发和发布采用这些新方法的免费软件。该项目预计将使需要从基因组数据推断系统发育的科学家受益。

This project aims to develop new methods and software to infer the evolutionary history of organisms using genomic data. These new phylogenomic methods need to take account of the complexity of evolutionary processes and/or patterns in time (along the evolutionary tree) and space (along the genome). This project is significant because these methods must merge mathematics and statistics with High-Performance Computing to handle the huge quantities of genetic data and the complexity of evolution itself. An important expected outcome of this project will be the development and release of freely-available software that incorporates these new methods. This project expects to benefit scientists who need to infer phylogenies from genomic data.