TOTAL SYNTHESIS OF ANTITUMOR TAXANES

通向全合成的合成方法学的发展 提出了紫杉醇的化学成分。紫杉醇是最有效的新型抗肿瘤药物之一。 药物前景，目前正处于第三阶段临床试验 卵巢癌和治疗乳腺癌的第二阶段临床试验。 其他临床试验也在计划中。紫杉醇的供应目前是 严格限制，并将药物合成的发展 有可能解决这个问题。此外，这项工作还将 提供允许合成大量紫杉醇的知识 模拟物，其中一些很可能具有更好的抗肿瘤活性 而不是紫杉醇本身。这些研究也将带来更好的 了解紫杉醇的作用机制，这反过来将导致 用于开发新的、优越的紫杉醇相关药物。

The development of synthetic methodology leading to the total synthesis of taxol is proposed. Taxol is one of the most potent new antitumor drug prospects, and it is currently in Phase III Clinical Trials against ovarian cancer and Phase II Clinical Trials against breast cancer. Other Clinical Trials are planned. The supply of taxol is currently severely limited, and development of synthesis of the drug will potentially solve this problem. In addition, this work will also provide the knowledge to permit the synthesis of a large number of taxol mimics, some of which are very likely to have better antitumor activity than taxol itself. These studies will also lead to a better understanding of taxol's mechanism of action, which, in turn, will lead to the development of new, superior taxol related drugs.