TOTAL SYNTHESIS OF ANTITUMOR TAXANES

这项研究的目的是发展综合方法论，它将 允许开发一种简短而有效的综合方法 抗肿瘤紫杉烷。其中有几个已经被证明是有效的抗肿瘤药物。 一种(紫杉醇)目前正在进行临床试验。 该项目的成功完成将提供充足的供应 紫杉醇，以及提供合成类似物，将用于 作为抗肿瘤药物进行测试。该项目还旨在提供新的 综合方法论将在以下领域具有普遍用途 化学合成。

The aim of this research is to develop synthetic methodologoy which will permit the development of a short and efficient general synthesis of antitumor taxanes. Several of these have been shown to be potent antitumor substances and one (taxol) is currently in clinical trials. Successful completion of this project will provide an abundant supply of taxol, as well as providing synthetic analogs which will be available for testing as antitumor agents. This project is also designed to provide new synthetic methodology which will be of general utility in the field of chemical synthesis.