TOTAL SYNTHESIS OF ANTITUMOR TAXANES

本研究的目的是开发综合方法， 允许开发一种短而有效的抗肿瘤药物的合成， 紫杉烷类 其中几种已被证明是有效的抗肿瘤 其中一种（紫杉醇）目前正在临床试验中。 成功 该项目的建成将为紫杉醇提供充足的供应， 以及提供合成类似物， 抗肿瘤剂。 该项目旨在提供新的合成 这将是在化学领域的通用方法 合成.

The aim of this research is to develop synthetic methodology which will permit the development of a short and efficient synthesis of anti-tumor taxanes. Several of these have been shown to be potent antitumor substances, and one (taxol) is currently in clinical trials. Successful completion of this project will provide an abundant supply of taxol, as well as providing synthetic analogs which will be available for testing as antitumor agents. This project is designed to also provide new synthetic methodology which will be of general utility in the field of chemical synthesis.