TOTAL SYNTHESIS OF ANTITUMOR TAXANES

这项研究的目的是开发综合方法学，它将 允许开发一种短而有效的抗肿瘤合成 紫杉烷。其中有几个已经被证明是有效的抗肿瘤药物。 其中一种(紫杉醇)目前正在进行临床试验。成功 该项目的完成将为紫杉醇提供充足的供应，因为 并提供可用于测试的合成类似物 抗肿瘤药物。该项目还旨在提供新的合成 方法学将在化学领域具有普遍用途 综合。

The aim of this research is to develop synthetic methodology which will permit the development of a short and efficient synthesis of anti-tumor taxanes. Several of these have been shown to be potent antitumor substances, and one (taxol) is currently in clinical trials. Successful completion of this project will provide an abundant supply of taxol, as well as providing synthetic analogs which will be available for testing as antitumor agents. This project is designed to also provide new synthetic methodology which will be of general utility in the field of chemical synthesis.