A novel, stationary 3D X-ray source for improved breast imaging

用于改善乳腺成像的新型固定 3D X 射线源

• 批准号: 104638
• 金额: $ 10.26万
• 依托单位: ADAPTIX LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=104638
• 关键词: novel; stationary; 3D; ray; source

"This project aims to show how breast cancer can be detected earlier by Adaptix's novel X-ray source.In the UK, 1 in 8 women will be diagnosed with breast cancer at some point in their life, the most common cancer in women in the UK (31% of cancers diagnosed in women are breast cancer). Earlier, more accurate detection enables better chances of survival and reduces the likelihood of needing radical surgery (mastectomy) and aggressive follow-up treatment.The Adaptix source will enable higher sensitivity compared to current 2D mammography systems where some cancers can be obscured by overlying tissue, especially in women with dense breasts. Our source uses a stationary array of small X-ray emitters, instead of a single source, thereby covering a range of angles and a unique way to derive 3D information about a breast. This will make the examination faster and more accurate than current 3D breast tomosynthesis systems that physically move the source, since the movement can blur fine detail such as calcifications seen in the early stages of cancer.Adaptix have already demonstrated the use of a flat panel X-ray source for analysing teeth and joints. Breast imaging requires the highest image quality of all X-ray procedures, and requires the Adaptix source to be larger and with a lower X-ray energy.This project will support Adaptix to work with Surrey University and RSCH, who have developed a complete set of end-to-end mammography simulation tools and will apply this to the Adaptix source. The software models every emitter's X-ray output, a chosen detector's exact response to X-rays, and uses these to virtually image a large range of detailed and realistic virtual breast models with and without cancer. The results are indistinguishable from real images. It means that a huge range of parameters can be experimented with and optimized without having to develop multiple physical prototypes or subject women to radiation in a clinical study.This project will demonstrate the theoretical advantages of the Adaptix source, which will help Adaptix secure a contract with a global medical systems company, to integrate this source into a new line of precision mammography devices for worldwide distribution.The UK invented the CT and MRI scanner, both of which are now manufactured off-shore. Supporting Adaptix will help bring another transformational UK technology to market and reduce the cost of world-class healthcare, as well as keeping production on-shore to secure UK manufacturing jobs."

“该项目旨在展示如何通过 Adaptix 的新型 X 射线源更早地检测出乳腺癌。在英国，八分之一的女性会在一生中的某个时刻被诊断出患有乳腺癌，这是英国女性中最常见的癌症（女性诊断出的癌症中有 31% 是乳腺癌）。更早、更准确的检测可以提高生存机会，并降低需要根治性手术（乳房切除术）和积极后续治疗的可能性。 与当前的 2D 乳房 X 线摄影系统相比，Adaptix 源将具有更高的灵敏度，在当前的 2D 乳房 X 线摄影系统中，某些癌症可能会被覆盖的组织所掩盖，尤其是对于乳房致密的女性。我们的源使用小型 X 射线发射器的固定阵列，而不是单个源，从而覆盖一系列角度并以独特的方式获取有关乳房的 3D 信息。这将使检查比当前物理移动的 3D 乳房断层合成系统更快、更准确 源，因为运动会模糊精细的细节，例如癌症早期阶段看到的钙化。Adaptix 已经演示了使用平板 X 射线源来分析牙齿和关节。乳腺成像对所有 X 射线程序中图像质量的要求最高，并且要求 Adaptix 源更大且具有更低的 X 射线能量。该项目将支持 Adaptix 与萨里大学和 RSCH 合作，后者开发了一套完整的 端到端乳腺 X 线摄影模拟工具，并将其应用于 Adaptix 源。该软件对每个发射器的 X 射线输出、所选探测器对 X 射线的精确响应进行建模，并使用这些模型对大量详细且逼真的患有或不患有癌症的虚拟乳房模型进行虚拟成像。结果与真实图像无法区分。这意味着可以对大量参数进行实验和优化，而无需开发多个物理原型或让女性接受辐射 该项目将展示 Adaptix 源的理论优势，这将帮助 Adaptix 与一家全球医疗系统公司签订合同，将该源集成到新的精密乳腺 X 光检查设备系列中，并在全球范围内销售。英国发明了 CT 和 MRI 扫描仪，这两种扫描仪现在都是在海外制造的。支持 Adaptix 将有助于将另一项英国变革性技术推向市场，并降低世界一流医疗保健的成本，因为 以及将生产保持在岸上以确保英国制造业的就业机会。”