Development of attenuated bovine herpesvirus-4 as a safe, inexpensive, single dose vaccine to control Streptococcus suis infection in domestic pigs

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Vaccines are one of medicine's greatest triumphs, having led to the virtual eradication of several deadlybacterial diseases. However, most vaccines in use today were developed by techniques pioneered over 100years ago and do not represent the full potential of the field. Bovine herpes virus vaccines (BoHV-4) are one ofthe most promising classes of new vaccines, combining durability of immunity with low costs of manufacture.In this project, we will develop a novel BoHV-4 vaccine against S. suis - a major disease affecting pig farmersworldwide and a dangerous zoonotic pathogen in humans. The applicants will develop the novel vaccine usingimmunogenic S. suis proteins and then test it in pigs to convincingly demonstrate both efficacy and aquantifiable reduction in antibiotic usage. Our objectives are firstly to commercialize the vaccine within 3 yearspost-project and secondly establish it as a flagship product within our powerful BoHV-4 platform which can betargeted at many other serious bacterial infections affecting both animal and human health. The project isinnovative in that there are currently no effective vaccines for the treatment and prevention of S. suis in pigs