Novel small molecule and TCM approaches to support pig production, minimizing generation of resistance to human antibiotics

支持养猪生产的新型小分子和中药方法，最大限度地减少对人类抗生素耐药性的产生

• 批准号: 104994
• 金额: $ 93.14万
• 依托单位: OXFORD DRUG DESIGN LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=104994
• 关键词: Novel; small; molecule; TCM; approaches

The emergence of resistance to antibiotics is a major health concern. To address this concern, this project willaddress multiple aspects of antibacterial resistance, bringing together complementary expertise in the UK andChina. Antibiotics are widely used in agriculture, where they have a valid role in protecting farm animals fromdisease and increasing food production. However, the use of antibiotics that are also used to treat humanscould lead to increased antimicrobial resistance. One of the aims of this project is to develop a new class ofantibiotics that are specific to a species of bacteria that cause infections in pigs, which would enable reduceduse of human antibiotics in farming. A second aspect of the proposal is to investigate the use of traditionalChinese medicines (TCMs) in veterinary settings. TCMs are typically complex mixtures with unknownmechanism of action. We will use sophisticated computational modelling methods, specifically a techniquecalled chemgenomics, to identify the active components of TCMs, which may enable further classes ofantibiotic to be rationally designed, or to be used synergistically with existing compounds.

抗生素耐药性的出现是一个主要的健康问题。为了解决这一问题，该项目将涉及抗菌耐药性的多个方面，汇集英国和中国的互补专业知识。抗生素广泛应用于农业，在保护农场动物免受疾病侵害和增加粮食产量方面发挥着有效作用。然而，使用也用于治疗人类的抗生素可能导致抗菌素耐药性增加。该项目的目标之一是开发一种新型抗生素，这种抗生素专门针对导致猪感染的一种细菌，这将有助于减少人类抗生素在农业中的使用。该提案的第二个方面是调查传统中药（tcm）在兽医环境中的使用。中药通常是具有未知作用机制的复杂混合物。我们将使用复杂的计算建模方法，特别是一种称为化学基因组学的技术，来识别中药的有效成分，这可能会使进一步的抗生素类别得到合理设计，或与现有化合物协同使用。